公开(公告)号：US11866699B2

公开(公告)日：2024-01-09

申请号：US16476917

申请日：2018-02-12

申请人： UNIVERSITY OF WASHINGTON

发明人： Marc Joseph Lajoie ,  Elizabeth Erin Gray ,  Neil P. King ,  Daniel Brewster Stetson ,  David Baker ,  Katherine DaPron

IPC分类号： C07H21/04 ,  C12N15/11 ,  C07K14/005 ,  C12N9/22 ,  C12N15/85

CPC分类号： C12N15/11 ,  C07K14/005 ,  C12N9/22 ,  C12N15/111 ,  C12N15/85 ,  C12Y301/21 ,  C12N2310/20 ,  C12N2800/80 ,  C12Q2521/301

摘要： The application discloses multimeric assemblies packaging one or more active component and their use to carry out nucleic acid regulation or gene editing.

公开(公告)号：US10851135B2

公开(公告)日：2020-12-01

申请号：US16796009

申请日：2020-02-20

申请人： UNIVERSITY OF WASHINGTON

发明人： Robert A. Langan ,  Scott Boyken ,  David Baker ,  Walter Novak ,  Marc Joseph Lajoie ,  Alfredo Quijano Rubio

IPC分类号： C07K14/00 ,  A61K47/69

摘要： Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.