公开(公告)号：US11820800B2

公开(公告)日：2023-11-21

申请号：US17285033

申请日：2019-11-04

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Zibo Chen ,  Scott Boyken ,  Sherry Bermeo ,  Robert A. Langan ,  David Baker

IPC: C07K14/00 ,  C07K14/435 ,  G01N33/53 ,  G16B15/00 ,  G16B5/00 ,  B82Y10/00 ,  G06N3/00 ,  H03K19/00 ,  B82Y5/00 ,  C07K19/00 ,  G16B5/10 ,  G16B5/30 ,  G01N33/542

CPC classification number: C07K14/435 ,  B82Y5/00 ,  B82Y10/00 ,  C07K14/00 ,  C07K19/00 ,  G01N33/53 ,  G06N3/002 ,  G16B5/00 ,  G16B15/00 ,  H03K19/00 ,  C07K2319/00 ,  G01N33/542 ,  G16B5/10 ,  G16B5/30 ,  Y10S977/914

Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.

公开(公告)号：US20240101615A1

公开(公告)日：2024-03-28

申请号：US18158384

申请日：2023-01-23

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Zibo CHEN ,  Scott Boyken ,  Sherry Bermeo ,  Robert A. Langan ,  David Baker

IPC: C07K14/435 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  C07K14/00 ,  C07K19/00 ,  G01N33/53 ,  G06N3/00 ,  G16B5/00 ,  G16B15/00 ,  H03K19/00

CPC classification number: C07K14/435 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y15/00 ,  C07K14/00 ,  C07K19/00 ,  G01N33/53 ,  G06N3/002 ,  G16B5/00 ,  G16B15/00 ,  H03K19/00 ,  C07K2319/00 ,  G16B5/10

Abstract: Disclosed herein are designed heterodimer proteins, monomeric polypeptides capable of forming heterodimer proteins, protein scaffolds including such polypeptides, and methods for using the heterodimer proteins and subunit polypeptides for designing logic gates.

公开(公告)号：US10851135B2

公开(公告)日：2020-12-01

申请号：US16796009

申请日：2020-02-20

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Robert A. Langan ,  Scott Boyken ,  David Baker ,  Walter Novak ,  Marc Joseph Lajoie ,  Alfredo Quijano Rubio

IPC: C07K14/00 ,  A61K47/69

Abstract: Disclosed are protein switches that can sequester bioactive peptides and/or binding domains, holding them in an inactive (“off”) state, until combined with a second designed polypeptide called the key, which induces a conformational change that activates (“on”) the bioactive peptide or binding domain, components of such protein switches, and their use.