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公开(公告)号：US20210088535A1
公开(公告)日：2021-03-25
申请号：US17035130
申请日：2020-09-28
Inventor： Daniel M. Ratner , Jill M. Johnsen , James T. Kirk , José A. López , Norman D. Brault , Shaoyi Jiang
IPC: G01N33/80 , G01N33/543 , G01N21/77
Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
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公开(公告)号：US11105820B2
公开(公告)日：2021-08-31
申请号：US17019022
申请日：2020-09-11
Inventor： Daniel M. Ratner , Jill M. Johnsen , James T. Kirk , José A. López , Norman D. Brault , Shaoyi Jiang
IPC: G01N21/77 , G01N33/80 , G01N33/543 , G01N21/75
Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
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Patent Agency Ranking
公开(公告)号：US10794921B2
公开(公告)日：2020-10-06
申请号：US16047911
申请日：2018-07-27
Inventor： Daniel M. Ratner , Jill M. Johnsen , James T. Kirk , José A. López , Norman D. Brault , Shaoyi Jiang
IPC: G01N33/80 , G01N33/543 , G01N21/77 , G01N21/75
Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
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公开(公告)号：US20160279251A1
公开(公告)日：2016-09-29
申请号：US15035721
申请日：2014-11-12
Inventor： Patrick S. Stayton , Anthony Convertine , Daniel M. Ratner , Selvi Srinivasan , Debobrato Das , Fang-Yi Su , Jasmin Chen , David Yee-Shawn Chiu , Daniel Douglas Lane
IPC: A61K47/48 , A61K31/407 , A61K31/4745 , A61K31/7036 , A61K31/337 , A61K31/496
CPC classification number: A61K47/58 , A61K9/1075 , A61K9/1271 , A61K31/337 , A61K31/407 , A61K31/4745 , A61K31/496 , A61K31/7036 , A61K47/60 , A61K47/644 , A61K47/6907 , A61K47/6915
Abstract: Provided herein are particles assemblies including a shell surrounding a core. The shell includes a particle-stabilizing random copolymer. The core includes a core random copolymer. The particle assemblies have a biomimetic design in which the polymeric components containing discrete chemical and biological functionalities are designed to spontaneously self-assemble into particles. Also provided herein are random copolymers having conjugated therapeutic agents that can be cleaved from the copolymers by an enzyme or water.
Abstract translation: 本文提供了包括围绕芯的壳的颗粒组件。 壳包括颗粒稳定的无规共聚物。 核心包括核心无规共聚物。 颗粒组件具有仿生设计，其中包含分立的化学和生物功能的聚合物组分被设计成自发地自组装成颗粒。 本文还提供了具有共轭治疗剂的无规共聚物，其可以通过酶或水从共聚物中裂解。
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公开(公告)号：US20190041410A1
公开(公告)日：2019-02-07
申请号：US16047911
申请日：2018-07-27
Inventor： Daniel M. Ratner , Jill M. Johnsen , James T. Kirk , José A. López , Norman D. Brault , Shaoyi Jiang
CPC classification number: G01N33/80 , G01N21/75 , G01N21/7703 , G01N33/54373
Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
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公开(公告)号：US10073102B2
公开(公告)日：2018-09-11
申请号：US15436585
申请日：2017-02-17
Inventor： Daniel M. Ratner , Jill M. Johnsen , James T. Kirk , José A. López , Norman D. Brault , Shaoyi Jiang
IPC: G01N33/80 , G01N33/543 , G01N21/77
CPC classification number: G01N33/80 , G01N21/75 , G01N21/7703 , G01N33/54373
Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
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公开(公告)号：US20170227555A1
公开(公告)日：2017-08-10
申请号：US15436585
申请日：2017-02-17
Applicant: University of Washington through its Center for Commercialization , Puget Sound Blood Center
Inventor： Daniel M. Ratner , Jill M. Johnsen , James T. Kirk , José A. López , Norman D. Brault , Shaoyi Jiang
IPC: G01N33/80 , G01N21/77 , G01N33/543
CPC classification number: G01N33/54373 , G01N21/75 , G01N33/80
Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.
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