公开(公告)号：US20170227555A1

公开(公告)日：2017-08-10

申请号：US15436585

申请日：2017-02-17

申请人： University of Washington through its Center for Commercialization ,  Puget Sound Blood Center

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N21/77 ,  G01N33/543

CPC分类号： G01N33/54373 ,  G01N21/75 ,  G01N33/80

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US20210088535A1

公开(公告)日：2021-03-25

申请号：US17035130

申请日：2020-09-28

申请人： University of Washington through its Center for Commercialization ,  Bloodworks

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N33/543 ,  G01N21/77

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US20170009069A1

公开(公告)日：2017-01-12

申请号：US15211278

申请日：2016-07-15

申请人： University of Washington through its Center for Commercialization

发明人： Shaoyi Jiang ,  Hong Xue ,  Wei Yang ,  Louisa R. Carr

IPC分类号： C08L33/14 ,  C08J3/075 ,  C12Q1/54

CPC分类号： C08L33/14 ,  A61K41/0019 ,  A61L27/34 ,  A61L27/52 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  C07C229/12 ,  C08F26/02 ,  C08J3/075 ,  C08J2433/14 ,  C08L33/10 ,  C08L2201/54 ,  C08L2312/00 ,  C12Q1/54 ,  C12Y101/03004 ,  G01N2333/904 ,  Y10T428/31786

摘要： Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

摘要翻译： 两性离子交联剂，由两性离子交联剂的两性离子单体共聚制备的交联的两性离子水凝胶，用于制备交联的两性离子水凝胶的方法，以及包括使用交联的两性离子水凝胶的方法的装置。

公开(公告)号：US20140221577A1

公开(公告)日：2014-08-07

申请号：US14140277

申请日：2013-12-24

申请人： University of Washington through its Center for Commercialization

发明人： Shaoyi Jiang ,  Zhiqiang Cao ,  Hong Xue ,  Lei Zhang

IPC分类号： A61K47/34

CPC分类号： A61K47/34 ,  A61K9/1075 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1273 ,  A61K9/5153 ,  A61K47/6911 ,  A61K47/6915 ,  C08F222/02 ,  C08F226/02 ,  C08F293/005 ,  C08F2438/01 ,  C08J3/126 ,  C08J2333/14

摘要： Zwitterionic block copolymers and zwitterionic conjugates that advantageously self-assemble into particles, particles assembled from the zwitterionic block copolymers and zwitterionic conjugates, pharmaceutical compositions that include the self-assembled particles, and methods for delivering therapeutic and diagnostic agents using the particles.

摘要翻译： 两性离子嵌段共聚物和两性离子共轭物，其有利地自组装成颗粒，由两性离子嵌段共聚物和两性离子共轭物组装的颗粒，包含自组装颗粒的药物组合物，以及使用该颗粒递送治疗剂和诊断剂的方法。

公开(公告)号：US20190041410A1

公开(公告)日：2019-02-07

申请号：US16047911

申请日：2018-07-27

申请人： University of Washington through its Center for Commercialization ,  Bloodworks

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N21/77

CPC分类号： G01N33/80 ,  G01N21/75 ,  G01N21/7703 ,  G01N33/54373

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US10073102B2

公开(公告)日：2018-09-11

申请号：US15436585

申请日：2017-02-17

申请人： University of Washington through its Center for Commercialization ,  Bloodworks

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N33/543 ,  G01N21/77

CPC分类号： G01N33/80 ,  G01N21/75 ,  G01N21/7703 ,  G01N33/54373

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US09738780B2

公开(公告)日：2017-08-22

申请号：US15211278

申请日：2016-07-15

申请人： University of Washington through its Center for Commercialization

发明人： Shaoyi Jiang ,  Hong Xue ,  Wei Yang ,  Louisa R. Carr

IPC分类号： C08L33/14 ,  A61K41/00 ,  A61L27/34 ,  A61L27/52 ,  A61L31/10 ,  C07C229/12 ,  A61L29/08 ,  A61L29/14 ,  A61L31/14 ,  C08F26/02 ,  C08L33/10 ,  C08J3/075 ,  C12Q1/54

CPC分类号： C08L33/14 ,  A61K41/0019 ,  A61L27/34 ,  A61L27/52 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  C07C229/12 ,  C08F26/02 ,  C08J3/075 ,  C08J2433/14 ,  C08L33/10 ,  C08L2201/54 ,  C08L2312/00 ,  C12Q1/54 ,  C12Y101/03004 ,  G01N2333/904 ,  Y10T428/31786

摘要： Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

公开(公告)号：US11105820B2

公开(公告)日：2021-08-31

申请号：US17019022

申请日：2020-09-11

申请人： University of Washington through its Center for Commercialization ,  Bloodworks

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N21/77 ,  G01N33/80 ,  G01N33/543 ,  G01N21/75

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US10794921B2

公开(公告)日：2020-10-06

申请号：US16047911

申请日：2018-07-27

申请人： University of Washington through its Center for Commercialization ,  Bloodworks

发明人： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC分类号： G01N33/80 ,  G01N33/543 ,  G01N21/77 ,  G01N21/75

摘要： Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US20190070300A1

公开(公告)日：2019-03-07

申请号：US16192321

申请日：2018-11-15

申请人： University of Washington through its Center for Commercialization

发明人： Shaoyi Jiang ,  Andrew Keefe ,  Hong Xue

IPC分类号： A61K47/58 ,  A61K38/48

摘要： Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.