公开(公告)号：US20240316130A1

公开(公告)日：2024-09-26

申请号：US18609666

申请日：2024-03-19

Applicant: UNM Rainforest Innovations

Inventor： Eric Bartee

IPC: A61K35/768 ,  C07K14/54 ,  C07K14/705 ,  C12N9/00 ,  C12N9/10 ,  C12N9/88 ,  C12N15/86

CPC classification number: A61K35/768 ,  C07K14/5434 ,  C07K14/70521 ,  C12N9/1018 ,  C12N9/88 ,  C12N9/93 ,  C12N15/86 ,  C12Y201/03003 ,  C12Y403/02001 ,  C12Y603/04005 ,  C12N2710/24032 ,  C12N2710/24043

Abstract: A replication-competent recombinant virus includes an expression cassette encoding a protein associated with arginine biosynthesis. The protein associated with arginine biosynthesis may include argininosuccinate synthase 1 (ASS1), argininosuccinate lyase (ASL), or ornithine transcarboxylase (OTC). The recombinant virus may be derived from a myxoma virus. A method of treating a cell includes contacting a cell with a recombinant virus including an expression cassette encoding a protein associated with arginine biosynthesis. The protein associated with arginine biosynthesis may be ASS1, ASL, OTC.