公开(公告)号：US20250032537A1

公开(公告)日：2025-01-30

申请号：US18782880

申请日：2024-07-24

Applicant: UOP LLC

Inventor： Gregory J. Lewis ,  Paulina Jakubczak ,  Mimoza Sylejmani-Rekaliu ,  William Sheets ,  Evgeny Kolev ,  Rodrigo Lobo ,  Keith Lehuta ,  Subhadra Chudasama

IPC: A61K33/26 ,  A61K9/00 ,  A61K33/00 ,  A61K33/06 ,  A61P39/04 ,  B01D15/36 ,  B01J39/02 ,  B01J39/09

Abstract: A process for removing Pb2+ ions from fluids, such as gastrointestinal fluids is described. The process involves contacting gastrointestinal fluid with a particulate metal titanate ion exchanger represented by the empirical formula: AmTixMyOz where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, lithium ion, calcium ion, magnesium ion, hydronium ion, and mixtures thereof, and M is optionally at least one framework metal selected from niobium (5+), zirconium (4+), tin (4+), iron (3+), iron (2+), cobalt (2+), and manganese (2+). The particulate metal titanate ion exchangers of the present disclosure are synthesized in the presence of complexing agents, including at least one multihydroxyl-containing complexing agent (MHCA), which facilitate metal transport and incorporation while imparting beneficial properties such as large aggregate size, well-behaved particle size distribution, and macroporosity.