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公开(公告)号：US20220096724A1
公开(公告)日：2022-03-31
申请号：US17396035
申请日：2021-08-06
Applicant: UOP LLC
Inventor： Francis Stephen Lupton , Gregory J. Lewis , James M. Hodges , Paulina Jakubczak , Mimoza Sylejmani-Rekaliu , William Sheets
IPC: A61M1/36 , A61M1/28 , A61K38/06 , A61K31/198 , A61K31/194 , A61K31/10 , A61K31/35 , A61K31/44 , A61K31/341 , A61K31/4184 , A61K33/24 , B01D15/36 , B01D69/08 , B01D69/14
Abstract: A process for removing Pb2+, Hg2+ and other heavy metal toxins from bodily fluids is disclosed. The process involves treating a patient with a small molecule heavy metal chelator to remove these toxins from bones and soft tissue cells into the blood or other bodily fluid. Then an ion exchange composition is used to ion exchange the heavy metal toxins from bodily fluids either within the body or by treatment outside the body such as by dialysis. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.
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公开(公告)号：US12121888B2
公开(公告)日：2024-10-22
申请号：US17408575
申请日：2021-08-23
Applicant: UOP LLC
Inventor： James M. Hodges , Mimoza Sylejmani-Rekaliu , Paulina Jakubczak , Evgeny Kolev , Gregory J. Lewis , William Sheets
CPC classification number: B01J39/09 , B01J39/02 , C01B33/20 , C01P2002/72
Abstract: A new family of rare-earth silicate compositions and the synthetic methods used to prepare them. The materials have open-framework structures and are characterized by their ion-exchange properties. They are represented by the following empirical formula:
Ar+pMs+1-xM′t+xSinOm
where A is an exchangeable cation such as sodium, M is at least one element selected from the group of rare-earth elements, and M′ is a framework metal having a valence of +2, +3, +4, or +5. The rare-earth silicate materials have utility in various cation-exchange applications such as dialysis and removal of toxic metals from the gastrointestinal tract.-
3.发明公开公开(公告)号：US20240307845A1
公开(公告)日：2024-09-19
申请号：US18677224
申请日：2024-05-29
Applicant: UOP LLC
Inventor： Gregory J. Lewis , Paulina Jakubczak , James M. Hodges , Evgeny Kolev , William Sheets , Mimoza Sylejmani-Rekaliu
CPC classification number: B01J20/16 , A61M1/3679 , B01D15/362 , B01J20/28026 , B01D2257/60
Abstract: A process for removing Pb2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula:
AmTiaNb1-aSixOy
having either the pharmacosiderite, sitinakite, pharmacosiderite-sitinakite intergrowth topologies or mixtures thereof. A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.-
公开(公告)号：US20250025868A1
公开(公告)日：2025-01-23
申请号：US18908241
申请日：2024-10-07
Applicant: UOP LLC
Inventor： James M. Hodges , Mimoza Sylejmani-Rekaliu , Paulina Jakubczak , Evgeny Kolev , Gregory J. Lewis , William Sheets
Abstract: A new family of rare-earth silicate compositions and the synthetic methods used to prepare them. The materials have open-framework structures and are characterized by their ion-exchange properties. They are represented by the following empirical formula: Ar+pMs+1−xM′t+xSinOm where A is an exchangeable cation such as sodium, M is at least one element selected from the group of rare-earth elements, and M′ is a framework metal having a valence of +2, +3, +4, or +5. The rare-earth silicate materials have utility in various cation-exchange applications such as dialysis and removal of toxic metals from the gastrointestinal tract.
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Patent Agency Ranking
5.发明授权公开(公告)号：US12036528B2
公开(公告)日：2024-07-16
申请号：US17403335
申请日：2021-08-16
Applicant: UOP LLC
Inventor： Gregory J. Lewis , Paulina Jakubczak , James M. Hodges , Evgeny Kolev , William Sheets , Mimoza Sylejmani-Rekaliu
CPC classification number: B01J20/16 , A61M1/3679 , B01D15/362 , B01J20/28026 , B01D2257/60
Abstract: A process for removing Pb2+ toxins from bodily fluids involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula:
AmTiaNb1-aSixOy
having either the pharmacosiderite, sitinakite, pharmacosiderite-sitinakite intergrowth topologies or mixtures thereof. There are also compositions comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.-
公开(公告)号：US20220096962A1
公开(公告)日：2022-03-31
申请号：US17406331
申请日：2021-08-19
Applicant: UOP LLC
Inventor： Mimoza Sylejmani-Rekaliu , James M. Hodges , Paulina Jakubczak , Evgeny Kolev , Gregory J. Lewis , William Sheets
IPC: B01D15/36 , A61M1/28 , A61M1/36 , A61M31/00 , A61K33/06 , A61K33/24 , A61P3/12 , B01D15/20 , B01D69/14 , B01D69/08 , B01J39/02 , B01J39/14 , B01J47/12
Abstract: A process for removing Pb2+, Hg2+, K+ and NH4+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula: Ar+pMs+1-xM′t+xSinOm A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.
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公开(公告)号：US20250032537A1
公开(公告)日：2025-01-30
申请号：US18782880
申请日：2024-07-24
Applicant: UOP LLC
Inventor： Gregory J. Lewis , Paulina Jakubczak , Mimoza Sylejmani-Rekaliu , William Sheets , Evgeny Kolev , Rodrigo Lobo , Keith Lehuta , Subhadra Chudasama
Abstract: A process for removing Pb2+ ions from fluids, such as gastrointestinal fluids is described. The process involves contacting gastrointestinal fluid with a particulate metal titanate ion exchanger represented by the empirical formula: AmTixMyOz where A is an exchangeable cation selected from the group consisting of potassium ion, sodium ion, lithium ion, calcium ion, magnesium ion, hydronium ion, and mixtures thereof, and M is optionally at least one framework metal selected from niobium (5+), zirconium (4+), tin (4+), iron (3+), iron (2+), cobalt (2+), and manganese (2+). The particulate metal titanate ion exchangers of the present disclosure are synthesized in the presence of complexing agents, including at least one multihydroxyl-containing complexing agent (MHCA), which facilitate metal transport and incorporation while imparting beneficial properties such as large aggregate size, well-behaved particle size distribution, and macroporosity.
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公开(公告)号：US20220097034A1
公开(公告)日：2022-03-31
申请号：US17408575
申请日：2021-08-23
Applicant: UOP LLC
Inventor： James M. Hodges , Mimoza Sylejmani-Rekaliu , Paulina Jakubczak , Evgeny Kolev , Gregory J. Lewis , William Sheets
Abstract: A new family of rare-earth silicate compositions and the synthetic methods used to prepare them. The materials have open-framework structures and are characterized by their ion-exchange properties. They are represented by the following empirical formula: Ar+pMs+1-xM′t+xSinOm where A is an exchangeable cation such as sodium, M is at least one element selected from the group of rare-earth elements, and M′ is a framework metal having a valence of +2, +3, +4, or +5. The rare-earth silicate materials have utility in various cation-exchange applications such as dialysis and removal of toxic metals from the gastrointestinal tract.
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9.发明申请公开(公告)号：US20220097019A1
公开(公告)日：2022-03-31
申请号：US17403335
申请日：2021-08-16
Applicant: UOP LLC
Inventor： Gregory J. Lewis , Paulina Jakubczak , James M. Hodges , Evgeny Kolev , William Sheets , Mimoza Sylejmani-Rekaliu
Abstract: A process for removing Pb2+ toxins from bodily fluids is disclosed. The process involves contacting the bodily fluid with an ion exchange composition to remove the metal toxins in the bodily fluid, including blood and gastrointestinal fluid. Alternatively, blood can be contacted with a dialysis solution which is then contacted with the ion exchange composition. The ion exchange compositions are represented by the following empirical formula: AmTiaNb1-aSixOy having either the pharmacosiderite, sitinakite, pharmacosiderite-sitinakite intergrowth topologies or mixtures thereof. A composition comprising the above ion exchange compositions in combination with bodily fluids or dialysis solution is also disclosed. The ion exchange compositions may be supported by porous networks of biocompatible polymers such as carbohydrates or proteins.
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