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1.发明授权Radioactive Jomol, its derivatives, processes for the production of these compounds, their use and product 失效放射性JOMOL，其衍生物，生产这些化合物的方法，其使用和产品
公开(公告)号：US5053216A
公开(公告)日：1991-10-01
申请号：US842313
申请日：1986-03-21
申请人： Udo Ehrenfeld
发明人： Udo Ehrenfeld
CPC分类号： C12P1/06
摘要： The invention relates to radioactively tagged Jomol, and its derivatives, diagnostic compositions, and pharmaceutical preparations containing such Jomol or its derivatives, as well as to products containing such Jomol and/or one of its derivatives and an adjuvant.
摘要翻译： 本发明涉及放射性标记的Jomol及其衍生物，诊断组合物和含有这种Jomol或其衍生物的药物制剂，以及含有这种Jomol和/或其衍生物和佐剂的产品。
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2.发明授权Jomol derivatives as agents for the use in malignant tumors and lowered immune defenses 失效JOMOL衍生物作为恶性肿瘤和降低免疫防御用药的代理
公开(公告)号：US5116614A
公开(公告)日：1992-05-26
申请号：US468269
申请日：1990-01-22
申请人： Udo Ehrenfeld
发明人： Udo Ehrenfeld
CPC分类号： C12P1/06
摘要： The invention relates to Jomol, processes for its production of Nocardia opaca cells (DSM 43202 or ATCC 21953, respectively), its derivatives, diagnostic compositions, and pharmaceutical preparations containing Jomol or its derivatives, as well as to products containing Jomol and/or one of its derivatives and an adjuvant.
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3.发明授权Agent and product for the diagnosis and treatment of tumors and for the treatment of weaknesses of the cellular and humoral immune defense 失效用于诊断和治疗肿瘤的药剂和产品，用于治疗细胞和体液免疫防御的弱点
公开(公告)号：US5021234A
公开(公告)日：1991-06-04
申请号：US485757
申请日：1990-02-26
申请人： Udo Ehrenfeld
发明人： Udo Ehrenfeld
IPC分类号： A61K38/00 , A61K9/127 , A61K31/11 , A61K31/115 , A61K33/40 , A61K35/74 , A61K45/00 , A61K49/00 , A61K51/00 , A61K51/12 , A61P35/00
CPC分类号： A61K49/0043 , A61K31/11 , A61K31/115 , A61K33/40 , A61K45/05 , A61K49/005 , A61K49/0084 , A61K51/1234 , A61K9/127 , A61K2121/00 , A61K2123/00 , Y10S435/832 , Y10S435/872 , Y10S435/879
摘要： An agent for the diagnosis and treatment of malignant tumors and for the treatment of lowered cellular and humoral immune defense is described which contains an immune modulator, a lipopolysaccharide or an immune modulator tagged with a radioactive tracer, a dyestuff or a cytostatic, or a similar polysaccharide, possibly in and/or on liposomes or lipidized. There is also described a product which contains the agent together with an adjuvant consisting of an aldehyde and an alcohol. There is also described a method for the diagnosis of malignant tumors comprising the step of administering to a mammal a diagnostic effective amount of the agent, optionally together with an adjuvant consisting of an aldehyde and an alcohol.
摘要翻译： 描述了用于诊断和治疗恶性肿瘤和用于治疗降低的细胞和体液免疫防御的药剂，其包含免疫调节剂，脂多糖或用放射性示踪剂，染料或细胞抑制剂或类似物标记的免疫调节剂 多糖，可能在脂质体中和/或脂质体上或脂质化。 还描述了一种产品，其含有由醛和醇组成的佐剂的试剂。 还描述了用于诊断恶性肿瘤的方法，其包括向哺乳动物施用诊断有效量的试剂，任选地与由醛和醇组成的佐剂的步骤。
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4.发明授权Agent facilitating liposome cellular wall transport, a method for the production thereof and its use 失效促进脂质体细胞壁转运的药剂，其生产方法及其用途
公开(公告)号：US4590060A
公开(公告)日：1986-05-20
申请号：US557738
申请日：1983-12-02
申请人： Udo Ehrenfeld
发明人： Udo Ehrenfeld
CPC分类号： A61K51/1234 , A61K31/11 , A61K31/115 , A61K33/40 , A61K51/1231 , B82Y5/00 , A61K2121/00 , A61K2123/00
摘要： An agent is described in which contains an aldehyde of formula IRCHO (I)in which R is a hydrogen atom, a straight-chain or branched hydrocarbon group having 1 to 4 carbon atoms, and preferably an alcohol of formula IIR'CH.sub.2 OH (II)in which R' has the meaning indicated above. The agent is used together with charged liposomes. By the administration of the agent, the permeability of the liposomes through tissue cell walls is substantially improved and tagged liposomes accumulate around and in a malignant tumor. A kit for use in diagnosis and therapy is also described.
摘要翻译： 描述了其中包含其中R是氢原子，具有1至4个碳原子的直链或支链烃基，优选式II R'CH2OH的醇的式I RCHO（I）的醛的试剂（ II）其中R'具有上述含义。 该试剂与带电脂质体一起使用。 通过施用该试剂，脂质体通过组织细胞壁的渗透性得到显着改善，并且标记脂质体在周围和恶性肿瘤中积聚。 还描述了用于诊断和治疗的试剂盒。
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