公开(公告)号：US20230043662A1

公开(公告)日：2023-02-09

申请号：US17793428

申请日：2020-12-30

申请人： Aslan Yavuz HABERDAR ,  Vladislav LASKAVYI

发明人： Aslan Yavuz HABERDAR

IPC分类号： A61K31/115 ,  A61K9/08 ,  A61K47/02

摘要： A method of producing a composition for a treatment of cardiovascular and cerebrovascular diseases is provided. The method includes the following steps of: a) according to a ratio of 1 lt, adding 2 ml 36.5-37.5% formic aldehyde solution to 998 ml sterile and 0.85-0.95% isotonic sodium chloride solution to obtain a mixture, mixing the mixture thoroughly and obtaining an aldehyde solution with a final concentration of 0.073-0.075% by weight for injection, and b) storing the composition obtained in a dark place at a temperature of 15-35° C.

公开(公告)号：US10105350B2

公开(公告)日：2018-10-23

申请号：US15125558

申请日：2015-03-12

申请人： David Choohyun Paik ,  Stephen Lewis Trokel

发明人： David Choohyun Paik ,  Stephen Lewis Trokel

IPC分类号： A61K31/4166 ,  A61K33/00 ,  A61K31/115 ,  A61K31/4178 ,  C07K14/78

摘要： A method of cross-linking collagen present in a collagenous tissue comprising contacting the collagenous tissue with an amount of a formaldehyde releasing agent effective to crosslink the collagen is provided. A method of inhibiting loss of structural integrity of a collagenous tissue during transplantation-related transport comprising contacting the collagenous tissue with an amount of a formaldehyde releasing agent effective to inhibit loss of structural integrity of the collagenous tissue is also provided. A composition for ophthalmic administration comprising a formaldehyde releasing agent, sodium bicarbonate, and ophthalmically suitable carriers or excipients is also provided. Finally, a method of altering the refractive power of a cornea comprising contacting the cornea with a formaldehyde releasing agent so as to effect cross-linking in the cornea and thereby alter the refractive power of the cornea is provided.

公开(公告)号：US20100144889A1

公开(公告)日：2010-06-10

申请号：US12451459

申请日：2008-04-02

申请人： Vladislav Nikolaevich Laskavy ,  Aleksandr Nikolaevich Shokhin ,  Sergei Ivanovich Ivanenko

发明人： Vladislav Nikolaevich Laskavy ,  Aleksandr Nikolaevich Shokhin ,  Sergei Ivanovich Ivanenko

IPC分类号： A61K31/115 ,  A61P3/06

CPC分类号： A61K31/115 ,  A61K9/2009 ,  A61K9/2018

摘要： The invention relates to medicine and can be used for producing a medicinal agent for normalising the cholesterol level. The aim of the invention is to develop a physiologically acceptable cholesterol-control agent which is nontoxic and does not cause addiction of organism. In preferred embodiments, the method for producing said agent consists in using 2-6 weight parts of a 36.5-40.0% formaldehyde medicinal solution and in adding 998-994 weight parts of a sterile 0.85-0.95% sodium chloride solution which is used for injection in such a way as to produce a 0.07-024% formaldehyde solution. The agent is stored at a temperature of 15-35° C. It also encompasses a method for treatment of patients for lowering their cholesterol levels that comprises administering the agent to the patients as intramuscular injections with a predetermined dose at a predetermined time interval.

摘要翻译： 本发明涉及药物，可用于制备用于使胆固醇水平正常化的药剂。 本发明的目的是开发一种无毒的生理学可接受的胆固醇控制剂，并且不会引起生物体成瘾。 在优选的实施方案中，制备所述试剂的方法包括使用2-6重量份的36.5-40.0％甲醛药用溶液，并加入998-994重量份的用于注射的无菌0.85-0.95％氯化钠溶液 以这种方式产生0.07-024％的甲醛溶液。 该试剂在15-35℃的温度下储存。它还包括治疗患者降低其胆固醇水平的方法，其包括以预定剂量以预定的时间间隔肌内注射给予患者药剂。

公开(公告)号：US20100093736A1

公开(公告)日：2010-04-15

申请号：US12521825

申请日：2007-12-13

申请人： Charles E. Coburn ,  John L. Pohlman ,  Bonnie A. Pyzowski ,  Patrick E. Brutto ,  George David Green ,  Raymond J. Swedo

发明人： Charles E. Coburn ,  John L. Pohlman ,  Bonnie A. Pyzowski ,  Patrick E. Brutto ,  George David Green ,  Raymond J. Swedo

IPC分类号： A61K31/53 ,  C09D5/16 ,  C09K5/04 ,  C09K8/22 ,  C09K8/524 ,  C11D17/08 ,  A01N43/80 ,  A61K31/115 ,  A61K47/18

CPC分类号： C09D5/14 ,  A01N33/08 ,  A01N43/80 ,  C07C215/08 ,  C10M141/06 ,  C10M141/08 ,  C10M2203/106 ,  C10M2207/023 ,  C10M2207/046 ,  C10M2207/08 ,  C10M2207/127 ,  C10M2207/18 ,  C10M2207/281 ,  C10M2211/042 ,  C10M2215/042 ,  C10M2215/044 ,  C10M2215/10 ,  C10M2215/102 ,  C10M2215/16 ,  C10M2215/202 ,  C10M2215/222 ,  C10M2215/226 ,  C10M2219/044 ,  C10M2219/066 ,  C10M2219/09 ,  C10M2219/104 ,  C10M2223/04 ,  C10N2230/16 ,  A01N35/02 ,  A01N43/64 ,  A01N47/12 ,  A01N2300/00

摘要： Biocidal compositions and their use in aqueous media, such as metalworking fluids, the compositions comprising a biocidal agent; and a non-biocidal primary amino alcohol compound of the formula (I); wherein R1, R2, R3, R4, and R5 are as defined herein.

摘要翻译： 杀生物剂组合物及其在含水介质如金属加工液中的用途，所述组合物包含杀生物剂; 和式（I）的非杀生物的伯氨基醇化合物; 其中R1，R2，R3，R4和R5如本文所定义。

公开(公告)号：US5643946A

公开(公告)日：1997-07-01

申请号：US443636

申请日：1995-05-18

申请人： Siegfried Benjamin Christensen, IV

发明人： Siegfried Benjamin Christensen, IV

IPC分类号： A61K31/215 ,  A61K31/275 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  A61P11/00 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07C43/205 ,  C07C43/225 ,  C07C43/23 ,  C07C61/28 ,  C07C69/003 ,  C07C69/712 ,  C07C69/75 ,  C07C69/753 ,  C07C237/30 ,  C07C255/46 ,  C07C259/06 ,  C07C259/08 ,  C07C309/65 ,  C07C311/15 ,  C07C319/12 ,  C07C323/60 ,  C07D257/04 ,  C07D271/06 ,  C07D271/10 ,  C07D285/12 ,  A61K31/115 ,  A61K31/085 ,  C07C49/355 ,  C07C69/96

CPC分类号： C07D257/04 ,  C07C255/46 ,  C07C259/08 ,  C07C323/60 ,  C07D271/06 ,  C07D271/10 ,  C07D285/12 ,  C07C2101/02 ,  C07C2101/08 ,  C07C2101/14 ,  C07C2101/16

摘要： Compounds of the formula ##STR1## wherein the substituents are as defined herein, are disclosed. Pharmaceutical compositions and methods of treating allergic and inflammatory diseases are also taught.

摘要翻译： 公开了其中取代基如本文所定义的式“IMAGE”的化合物。 还教导了治疗过敏性和炎性疾病的药物组合物和方法。

公开(公告)号：US5021234A

公开(公告)日：1991-06-04

申请号：US485757

申请日：1990-02-26

申请人： Udo Ehrenfeld

发明人： Udo Ehrenfeld

IPC分类号： A61K38/00 ,  A61K9/127 ,  A61K31/11 ,  A61K31/115 ,  A61K33/40 ,  A61K35/74 ,  A61K45/00 ,  A61K49/00 ,  A61K51/00 ,  A61K51/12 ,  A61P35/00

CPC分类号： A61K49/0043 ,  A61K31/11 ,  A61K31/115 ,  A61K33/40 ,  A61K45/05 ,  A61K49/005 ,  A61K49/0084 ,  A61K51/1234 ,  A61K9/127 ,  A61K2121/00 ,  A61K2123/00 ,  Y10S435/832 ,  Y10S435/872 ,  Y10S435/879

摘要： An agent for the diagnosis and treatment of malignant tumors and for the treatment of lowered cellular and humoral immune defense is described which contains an immune modulator, a lipopolysaccharide or an immune modulator tagged with a radioactive tracer, a dyestuff or a cytostatic, or a similar polysaccharide, possibly in and/or on liposomes or lipidized. There is also described a product which contains the agent together with an adjuvant consisting of an aldehyde and an alcohol. There is also described a method for the diagnosis of malignant tumors comprising the step of administering to a mammal a diagnostic effective amount of the agent, optionally together with an adjuvant consisting of an aldehyde and an alcohol.

摘要翻译： 描述了用于诊断和治疗恶性肿瘤和用于治疗降低的细胞和体液免疫防御的药剂，其包含免疫调节剂，脂多糖或用放射性示踪剂，染料或细胞抑制剂或类似物标记的免疫调节剂 多糖，可能在脂质体中和/或脂质体上或脂质化。 还描述了一种产品，其含有由醛和醇组成的佐剂的试剂。 还描述了用于诊断恶性肿瘤的方法，其包括向哺乳动物施用诊断有效量的试剂，任选地与由醛和醇组成的佐剂的步骤。

公开(公告)号：US4252785A

公开(公告)日：1981-02-24

申请号：US56122

申请日：1979-07-09

申请人： Donald J. Isoldi

发明人： Donald J. Isoldi

IPC分类号： A61K9/20 ,  A61K9/22 ,  A61L9/04 ,  A61L9/05 ,  C11D17/04 ,  A61K9/26 ,  A61K31/115 ,  A61K31/785

CPC分类号： A61L9/042 ,  A61K9/2031 ,  A61L9/05 ,  C11D17/041

摘要： A microporous controlled release composition, comprising at least about 20%, by weight, based on the total weight of the composition, of a solid, low molecular weight urea-formaldehyde resin having a molar ratio of urea to formaldehyde of from about 2:1 to about 3.5:1, and at least one active material contained in and releasable from said resin over a sustained period of time when said resin is in an aqueous medium.

摘要翻译： 一种微孔控释组合物，其包含至少约20重量％，基于组合物的总重量，具有约2:1的脲与甲醛的摩尔比的固体低分子量脲甲醛树脂 至约3.5:1，以及当所述树脂在水性介质中时，在持续的时间内包含并可从所述树脂中释放的至少一种活性物质。

公开(公告)号：US4007264A

公开(公告)日：1977-02-08

申请号：US545160

申请日：1975-01-30

申请人： Andre Queuille ,  Raymond Larde

发明人： Andre Queuille ,  Raymond Larde

IPC分类号： A61K31/115 ,  A61K38/00 ,  A61K38/17 ,  C07K14/47 ,  A61K31/74

CPC分类号： C07K14/4732 ,  A61K38/00

摘要： The method of treating chronic or infectious diarrhea by oral administration of an effective amount of a formaldehyde-modified casein; as well as pharmaceutical compositions.

摘要翻译： 通过口服给药有效量的甲醛改性酪蛋白治疗慢性或感染性腹泻的方法; 以及药物组合物。

公开(公告)号：US20220257530A1

公开(公告)日：2022-08-18

申请号：US17730037

申请日：2022-04-26

申请人： Provita Eurotech Ltd

发明人： Michael Kerr ,  Teresa Allen

IPC分类号： A61K31/115 ,  A61K33/34 ,  A61K47/10 ,  A61K47/12 ,  A61K47/44

摘要： There is provided a composition comprising an organic material and at least a first surfactant which following addition of an aqueous solution to the composition can form a biphasic system, wherein the biphasic system is useful for the treatment of or prevention of hoof infections. Also provided is a biphasic system useful for the treatment of or prevention of hoof infections, wherein the biphasic system comprises the composition and an aqueous phase wherein the composition is dispersed as droplets within the aqueous phase.

公开(公告)号：US10772850B2

公开(公告)日：2020-09-15

申请号：US16838829

申请日：2020-04-02

申请人： ANTECIP BIOVENTURES II LLC

发明人： Herriot Tabuteau

IPC分类号： A61K31/137 ,  A61K31/381 ,  A61K31/485 ,  A61K31/135 ,  A61K31/115

摘要： Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.