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1.发明授权Sulfoximine-substituted pyrimidines as CDK- and/or VEGF inhibitors, their production and use as pharmaceutical agents 失效磺酰亚胺取代的嘧啶作为CDK和/或VEGF抑制剂，其生产和用作药剂公开(公告)号：US08507510B2
公开(公告)日：2013-08-13
申请号：US12095947
申请日：2004-10-12
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D239/47 , C07D239/48
摘要： This invention relates to pyrimidine derivatives of general formula I in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of cyclin-dependent kinases and VEGF-receptor tyrosine kinases, their production as well as their use as medications for treatment of various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中Q，R 1，R 2，R 3，R 4，R 5，X和m具有说明书中所含的含义，作为细胞周期蛋白依赖性激酶和VEGF受体酪氨酸的抑制剂 激酶，它们的生产以及用作治疗各种疾病的药物。
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2.发明申请SULFOXIMINE-SUBSTITUTED PYRIMIDINES AS CDK- AND/OR VEGF INHIBITORS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS 失效作为CDK-和/或VEGF抑制剂的SULFOXIMINE-取代的吡咯烷酮，其生产和用作药物代理公开(公告)号：US20100076000A1
公开(公告)日：2010-03-25
申请号：US12095947
申请日：2004-10-12
IPC分类号： A61K31/505 , C07D239/48 , C07D239/47 , A61P35/00 , A61P25/00 , A61P31/00
CPC分类号： C07D239/47 , C07D239/48
摘要： This invention relates to pyrimidine derivatives of general formula I in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of cyclin-dependent kinases and VEGF-receptor tyrosine kinases, their production as well as their use as medications for treatment of various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中Q，R 1，R 2，R 3，R 4，R 5，X和m具有说明书中所含的含义，作为细胞周期蛋白依赖性激酶和VEGF受体酪氨酸的抑制剂 激酶，它们的生产以及用作治疗各种疾病的药物。
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3.发明授权Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine 有权砜取代的苯胺基嘧啶衍生物作为CDK抑制剂，其制备及用作药物公开(公告)号：US08802686B2
公开(公告)日：2014-08-12
申请号：US13125144
申请日：2009-10-08
IPC分类号： A61K31/505 , C07D239/24
CPC分类号： C07D239/47
摘要： The invention relates to sulphone-substituted anilinopyrimidine derivatives of the formula (I), to its preparation processes, and to its use as medicament for treating various diseases.
摘要翻译： 本发明涉及式（I）的砜取代的苯胺基嘧啶衍生物及其制备方法，以及其用作治疗各种疾病的药物。
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4.发明授权公开(公告)号：US07291624B2
公开(公告)日：2007-11-06
申请号：US10842419
申请日：2004-05-11
申请人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
发明人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/6512
摘要： This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中R 1，R 2，X，A和B具有说明书中所含的含义，作为 细胞周期蛋白依赖性激酶，其生产以及用作治疗各种疾病的药物。
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5.发明授权公开(公告)号：US07598260B2
公开(公告)日：2009-10-06
申请号：US11819307
申请日：2007-06-26
申请人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
发明人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/6512
摘要： This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及通式Ⅰ的嘧啶衍生物，其中R1，R2，X，A和B具有说明书中所含的含义，作为细胞周期蛋白依赖性激酶的抑制剂，其生产及其用作药物用途 治疗各种疾病。
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6.发明申请SULFOXIMINE-SUBSTITUTED ANILINOPYRIMIDINE DERIVATIVES AS CDK INHIBITORS, THE PRODUCTION THEREOF, AND USE AS MEDICINE 有权作为CDK抑制剂的SULFOXIMINE取代的抗胰蛋白胨衍生物，其生产和用作医药公开(公告)号：US20110294838A1
公开(公告)日：2011-12-01
申请号：US13125066
申请日：2009-10-09
IPC分类号： A61K31/505 , C07D239/48 , A61P35/00 , C07D239/47
CPC分类号： C07D239/47
摘要： The invention relates to sulfoximine-substituted anilino-pyrimidine derivatives of formula (I). methods of production thereof, and use thereof as medication for the treatment of various diseases.
摘要翻译： 本发明涉及式（I）的磺酰亚胺取代的苯胺基 - 嘧啶衍生物。 其生产方法及其用作治疗各种疾病的药物。
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7.发明授权CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents 失效CDK抑制性2-杂芳基嘧啶，它们的生产和用作药剂公开(公告)号：US07288547B2
公开(公告)日：2007-10-30
申请号：US10384787
申请日：2003-10-27
申请人： Ulrich Lücking , Martin Kruger , Rolf Jautelat , Olaf Prien , Gerhard Siemeister , Alexander Ernst
发明人： Ulrich Lücking , Martin Kruger , Rolf Jautelat , Olaf Prien , Gerhard Siemeister , Alexander Ernst
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/433 , A61K31/4196 , A61P35/00 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , A61K31/4427 , A61K31/381
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： This invention relates to 2-heteroaryl-pyrimidine derivatives of general formula I or If as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及作为细胞周期蛋白依赖性激酶的抑制剂的通式I或I的2-杂芳基 - 嘧啶衍生物，其制备及其作为治疗各种疾病的药物的用途。
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公开(公告)号：US07235561B2
公开(公告)日：2007-06-26
申请号：US10156759
申请日：2002-05-29
申请人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
发明人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
IPC分类号： A61K31/505 , C07D239/02 , A61P35/00
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/6512
摘要： This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中R 1，R 2，X，A和B具有说明书中所含的含义，作为 细胞周期蛋白依赖性激酶，其生产以及用作治疗各种疾病的药物。
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9.发明授权Sulfoximine-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as medicine 有权磺酰亚胺取代的苯胺基嘧啶衍生物作为CDK抑制剂，其制备及用作药物公开(公告)号：US08735412B2
公开(公告)日：2014-05-27
申请号：US13125066
申请日：2009-10-09
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/47
摘要： The invention relates to sulfoximine-substituted anilino-pyrimidine derivatives of formula (I). methods of production thereof, and use thereof as medication for the treatment of various diseases.
摘要翻译： 本发明涉及式（I）的磺酰亚胺取代的苯胺基 - 嘧啶衍生物。 其生产方法及其用作治疗各种疾病的药物。
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10.发明申请SULFONE-SUBSTITUTED ANILINOPYRIMIDINE DERIVATIVES AS CDK INHIBITORS, THE PRODUCTION THEREOF, AND USE AS A MEDICINE 有权作为CDK抑制剂的磺基取代的苯胺二酮衍生物，其生产和用作药物公开(公告)号：US20110251222A1
公开(公告)日：2011-10-13
申请号：US13125144
申请日：2009-10-08
IPC分类号： A61K31/505 , A61P17/04 , A61P31/00 , A61P25/00 , C07D239/48 , A61P35/00
CPC分类号： C07D239/47
摘要： The invention relates to sulphone-substituted anilinopyrimidine derivatives of the formula (I), to its preparation processes, and to its use as medicament for treating various diseases.
摘要翻译： 本发明涉及式（I）的砜取代的苯胺基嘧啶衍生物及其制备方法及其用作治疗各种疾病的药物。
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