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    VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
    4.
    发明申请
    VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines 失效
    VEGFR-2和VEGFR-3抑制性邻氨基苯甲酰胺吡啶

    公开(公告)号：US20070015794A1

    公开(公告)日：2007-01-18

    申请号：US11525091

    申请日：2006-09-22

    申请人： Andreas Huth ,  Ludwig Zorn ,  Martin Kruger ,  Stuart Ince ,  Karl-Heinz Thierauch ,  Andreas Menrad ,  Martin Haberey ,  Holger Hess-Stumpp

    发明人： Andreas Huth ,  Ludwig Zorn ,  Martin Kruger ,  Stuart Ince ,  Karl-Heinz Thierauch ,  Andreas Menrad ,  Martin Haberey ,  Holger Hess-Stumpp

    IPC分类号： A61K31/444 ,  A61K31/44 ,  C07D401/02 ,  C07D213/72

    CPC分类号： C07D213/72 ,  C07D401/02

    摘要： VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridinamides, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis, as well as intermediate products for the production of the compounds are described. The compounds according to the invention can be used as or in the case of tumor or metastasis growth, psoriasis, Kaposi's sarcoma, restenosis, such as, e.g., stent-induced restenosis, endometriosis, Crohn's disease, Hodgkin's disease, leukemia; arthritis, such as rheumatoid arthritis, hemangioma, angiofibroma; eye diseases, such as diabetic retinopathy, neovascular glaucoma; renal diseases, such as glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombic microangiopathic syndrome, transplant rejections and glomerulopathy; fibrotic diseases, such as cirrhosis of the liver, mesangial cell proliferative diseases, arteriosclerosis, injuries to nerve tissue, and inhibition of the reocclusion of vessels after balloon catheter treatment, in vascular prosthetics or after mechanical devices are used to keep vessels open, such as, e.g., stents, as immunosuppressive agents, as a support in scar-free healing, senile keratosis and contact dermatitis. The compounds according to the invention can also be used as VEGFR-3 inhibitors in the case of lymphangiogenesis.

    摘要翻译： 描述了VEGFR-2和VEGFR-3抑制性邻氨基苯酰胺吡啶酰胺，其作为用于治疗由持续血管发生引起的疾病的药物的制备和用途，以及用于制备化合物的中间产物。 根据本发明的化合物可用于或在肿瘤或转移生长的情况下，牛皮癣，卡波西肉瘤，再狭窄，例如支架诱导的再狭窄，子宫内膜异位，克罗恩病，霍奇金病，白血病; 关节炎，如类风湿关节炎，血管瘤，血管纤维瘤; 眼睛疾病如糖尿病性视网膜病变，新生血管性青光眼; 肾脏疾病如肾小球性肾炎，糖尿病肾病，恶性肾硬化，血栓性微血管病综合征，移植排斥反应和肾小球病; 纤维化疾病，如肝硬化，肾小球膜细胞增生性疾病，动脉硬化，神经组织损伤，以及球囊导管治疗后血管再狭窄的抑制，血管修复术或机械装置用于保持血管开放的诸如 例如作为免疫抑制剂的支架，作为无疤痕愈合的支持，老年角化病和接触性皮炎。 在淋巴管生成的情况下，根据本发明的化合物也可以用作VEGFR-3抑制剂。

    Method for producing 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones
    5.
    发明授权
    Method for producing 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones 失效
    4-（杂芳基 - 甲基） - 卤素-1（2H） - 酞嗪酮的制备方法

    公开(公告)号：US06891041B2

    公开(公告)日：2005-05-10

    申请号：US10168794

    申请日：2000-12-20

    申请人： Orlin Petrov ,  Thomas Heiner ,  Herribert Neh ,  Martin Kruger

    发明人： Orlin Petrov ,  Thomas Heiner ,  Herribert Neh ,  Martin Kruger

    IPC分类号： C07D401/06 ,  C07D403/06

    CPC分类号： C07D401/06

    摘要： A process for the production of 4-(heteroaryl-methyl)-halogen-1(2H)-phthalazinones, especially 4-(4-pyridylmethyl)-1(2H)-phthalazinone, is described, which is characterized by the reaction of phthalidyl-3-triphenylphosphonium salt with 4-pyridine aldehyde in the presence of a basic adjuvant, subsequent reaction with hydrazine hydrate and subsequent acid treatment, whereby this process avoids the technical safety and environmental problems of the known processes.

    摘要翻译： 描述了制备4-（杂芳基 - 甲基） - 卤素-1（2H） - 酞嗪酮，特别是4-（4-吡啶基甲基）-1（2H） - 酞嗪酮的方法，其特征在于苯酞 -3-三苯基鏻盐与4-吡啶醛在碱性助剂的存在下反应，随后与水合肼反应并随后进行酸处理，由此该方法避免了已知方法的技术安全性和环境问题。

    Device and method for down-mixing of a radio-frequency signal, which has been received by radio, to baseband
    6.
    发明申请
    Device and method for down-mixing of a radio-frequency signal, which has been received by radio, to baseband 审中-公开
    将由无线电接收的射频信号下混合到基带的装置和方法

    公开(公告)号：US20050254599A1

    公开(公告)日：2005-11-17

    申请号：US11118856

    申请日：2005-04-29

    申请人： Xiaofeng Wu ,  Martin Kruger ,  Holger Neuhaus

    发明人： Xiaofeng Wu ,  Martin Kruger ,  Holger Neuhaus

    IPC分类号： H03D7/00 ,  H04B1/26 ,  H04B1/28 ,  H04L27/06 ,  H04L27/14 ,  H04L27/233

    CPC分类号： H04L27/2338 ,  H04B1/28

    摘要： A receiver device includes a first mixer for production of a first analogue intermediate signal by down-mixing of a radio-frequency signal. The device also includes an A/D converter for production of a first digital intermediate signal, a second mixer for production of a second digital intermediate signal from the first digital intermediate signal, and a third mixer for production of a digital baseband signal from the second digital intermediate signal. The second mixer has a higher sampling frequency than the third mixer.

    摘要翻译： 接收机装置包括：第一混频器，用于通过降低混合射频信号来产生第一模拟中间信号。 该装置还包括用于产生第一数字中间信号的A / D转换器，用于从第一数字中间信号产生第二数字中间信号的第二混频器和用于从第二数字中间信号产生数字基带信号的第三混频器 数字中间信号。 第二混频器具有比第三混频器更高的采样频率。

    Method and receiving unit for compensation for a frequency offset and/or for a change in the phase of a transmission channel over time by receiver-end evaluation of edge symbols of a received data burst
    7.
    发明申请
    Method and receiving unit for compensation for a frequency offset and/or for a change in the phase of a transmission channel over time by receiver-end evaluation of edge symbols of a received data burst 有权
    方法和接收单元，用于通过对接收到的数据突发的边缘符号进行接收机端评估来补偿频率偏移和/或用于随时间变化的传输信道的相位

    公开(公告)号：US20050089115A1

    公开(公告)日：2005-04-28

    申请号：US10935447

    申请日：2004-09-07

    申请人： Ralf Hartmann ,  Martin Kruger ,  Hartmut Wilhelm

    发明人： Ralf Hartmann ,  Martin Kruger ,  Hartmut Wilhelm

    IPC分类号： H04L27/00 ,  H04L27/22 ,  H04B15/00

    CPC分类号： H04L27/22 ,  H04L2027/0024 ,  H04L2027/0046 ,  H04L2027/0065 ,  H04L2027/0093

    摘要： In order to compensate for a frequency offset or a change in the phase of the transmission channel over time during mobile radio transmission of data symbols, the data symbols are transmitted by means of carrier-frequency, modulated data bursts. Sample values of the received signal, which are known in advance and correspond to first and second symbols, are evaluated in order to estimate the frequency offset or the change in the phase of the transmission channel over time. These first and second symbols are transmitted with a defined phase angle by means of the data burst, and are arranged separated from one another in the data burst. Edge symbols in a data burst are advantageously used as first and second symbols, or as a symbol pair, for estimation.

    摘要翻译： 为了补偿在数据符号的移动无线电传输期间随着时间的传输信道的频率偏移或相位变化，数据符号通过载波频率调制的数据脉冲串发送。 对预先已知并对应于第一和第二符号的接收信号的采样值进行评估，以估计传输信道随时间的频率偏移或相位变化。 这些第一和第二符号通过数据脉冲串以规定的相位角发送，并且在数据脉冲串中彼此分离布置。 数据突发中的边缘符号有利地用作第一和第二符号，或作为符号对用于估计。