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公开(公告)号：US07235561B2
公开(公告)日：2007-06-26
申请号：US10156759
申请日：2002-05-29
申请人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
发明人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
IPC分类号： A61K31/505 , C07D239/02 , A61P35/00
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/6512
摘要： This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中R 1，R 2，X，A和B具有说明书中所含的含义，作为 细胞周期蛋白依赖性激酶，其生产以及用作治疗各种疾病的药物。
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2.发明授权公开(公告)号：US07291624B2
公开(公告)日：2007-11-06
申请号：US10842419
申请日：2004-05-11
申请人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
发明人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/6512
摘要： This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中R 1，R 2，X，A和B具有说明书中所含的含义，作为 细胞周期蛋白依赖性激酶，其生产以及用作治疗各种疾病的药物。
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3.发明授权公开(公告)号：US07598260B2
公开(公告)日：2009-10-06
申请号：US11819307
申请日：2007-06-26
申请人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
发明人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schäfer , Gerhard Siemeister , Ulrich Lücking , Christoph Huwe
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/6512
摘要： This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及通式Ⅰ的嘧啶衍生物，其中R1，R2，X，A和B具有说明书中所含的含义，作为细胞周期蛋白依赖性激酶的抑制剂，其生产及其用作药物用途 治疗各种疾病。
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4.发明申请公开(公告)号：US20080039447A1
公开(公告)日：2008-02-14
申请号：US11819307
申请日：2007-06-26
申请人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schafer , Gerhard Siemeister , Ulrich Lucking , Christoph Huwe
发明人： Thomas Brumby , Rolf Jautelat , Olaf Prien , Martina Schafer , Gerhard Siemeister , Ulrich Lucking , Christoph Huwe
IPC分类号： A61K31/505 , A61K31/496 , A61K31/5377 , A61K31/551 , A61P17/06 , A61P25/00 , A61P25/16 , A61P25/28 , A61P31/00 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P37/00 , A61P9/00 , C07D239/42 , C07D239/48 , C07D243/08 , C07D401/10 , C07D411/10
CPC分类号： C07D239/42 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/48 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/14 , C07D417/12 , C07D495/10 , C07F9/6512
摘要： This invention relates to pyrimidine derivatives of general formula I in which R1, R2, X, A and B have the meanings that are contained in the description, as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中R 1，R 2，X，A和B具有说明书中所含的含义，作为 细胞周期蛋白依赖性激酶，其生产以及用作治疗各种疾病的药物。
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5.发明授权CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents 失效CDK抑制性2-杂芳基嘧啶，它们的生产和用作药剂公开(公告)号：US07288547B2
公开(公告)日：2007-10-30
申请号：US10384787
申请日：2003-10-27
申请人： Ulrich Lücking , Martin Kruger , Rolf Jautelat , Olaf Prien , Gerhard Siemeister , Alexander Ernst
发明人： Ulrich Lücking , Martin Kruger , Rolf Jautelat , Olaf Prien , Gerhard Siemeister , Alexander Ernst
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/433 , A61K31/4196 , A61P35/00 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , A61K31/4427 , A61K31/381
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： This invention relates to 2-heteroaryl-pyrimidine derivatives of general formula I or If as inhibitors of the cyclin-dependent kinases, their production as well as their use as medications for treating various diseases.
摘要翻译： 本发明涉及作为细胞周期蛋白依赖性激酶的抑制剂的通式I或I的2-杂芳基 - 嘧啶衍生物，其制备及其作为治疗各种疾病的药物的用途。
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6.发明授权Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine 有权砜取代的苯胺基嘧啶衍生物作为CDK抑制剂，其制备及用作药物公开(公告)号：US08802686B2
公开(公告)日：2014-08-12
申请号：US13125144
申请日：2009-10-08
IPC分类号： A61K31/505 , C07D239/24
CPC分类号： C07D239/47
摘要： The invention relates to sulphone-substituted anilinopyrimidine derivatives of the formula (I), to its preparation processes, and to its use as medicament for treating various diseases.
摘要翻译： 本发明涉及式（I）的砜取代的苯胺基嘧啶衍生物及其制备方法，以及其用作治疗各种疾病的药物。
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7.发明授权Sulfoximine-substituted pyrimidines as CDK- and/or VEGF inhibitors, their production and use as pharmaceutical agents 失效磺酰亚胺取代的嘧啶作为CDK和/或VEGF抑制剂，其生产和用作药剂公开(公告)号：US08507510B2
公开(公告)日：2013-08-13
申请号：US12095947
申请日：2004-10-12
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D239/47 , C07D239/48
摘要： This invention relates to pyrimidine derivatives of general formula I in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of cyclin-dependent kinases and VEGF-receptor tyrosine kinases, their production as well as their use as medications for treatment of various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中Q，R 1，R 2，R 3，R 4，R 5，X和m具有说明书中所含的含义，作为细胞周期蛋白依赖性激酶和VEGF受体酪氨酸的抑制剂 激酶，它们的生产以及用作治疗各种疾病的药物。
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8.发明申请SULFOXIMINE-SUBSTITUTED PYRIMIDINES AS CDK- AND/OR VEGF INHIBITORS, THEIR PRODUCTION AND USE AS PHARMACEUTICAL AGENTS 失效作为CDK-和/或VEGF抑制剂的SULFOXIMINE-取代的吡咯烷酮，其生产和用作药物代理公开(公告)号：US20100076000A1
公开(公告)日：2010-03-25
申请号：US12095947
申请日：2004-10-12
IPC分类号： A61K31/505 , C07D239/48 , C07D239/47 , A61P35/00 , A61P25/00 , A61P31/00
CPC分类号： C07D239/47 , C07D239/48
摘要： This invention relates to pyrimidine derivatives of general formula I in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of cyclin-dependent kinases and VEGF-receptor tyrosine kinases, their production as well as their use as medications for treatment of various diseases.
摘要翻译： 本发明涉及通式I的嘧啶衍生物，其中Q，R 1，R 2，R 3，R 4，R 5，X和m具有说明书中所含的含义，作为细胞周期蛋白依赖性激酶和VEGF受体酪氨酸的抑制剂 激酶，它们的生产以及用作治疗各种疾病的药物。
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9.发明申请SULFOXIMINE-SUBSTITUTED ANILINOPYRIMIDINE DERIVATIVES AS CDK INHIBITORS, THE PRODUCTION THEREOF, AND USE AS MEDICINE 有权作为CDK抑制剂的SULFOXIMINE取代的抗胰蛋白胨衍生物，其生产和用作医药公开(公告)号：US20110294838A1
公开(公告)日：2011-12-01
申请号：US13125066
申请日：2009-10-09
IPC分类号： A61K31/505 , C07D239/48 , A61P35/00 , C07D239/47
CPC分类号： C07D239/47
摘要： The invention relates to sulfoximine-substituted anilino-pyrimidine derivatives of formula (I). methods of production thereof, and use thereof as medication for the treatment of various diseases.
摘要翻译： 本发明涉及式（I）的磺酰亚胺取代的苯胺基 - 嘧啶衍生物。 其生产方法及其用作治疗各种疾病的药物。
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10.发明授权Sulfoximine-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as medicine 有权磺酰亚胺取代的苯胺基嘧啶衍生物作为CDK抑制剂，其制备及用作药物公开(公告)号：US08735412B2
公开(公告)日：2014-05-27
申请号：US13125066
申请日：2009-10-09
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D239/47
摘要： The invention relates to sulfoximine-substituted anilino-pyrimidine derivatives of formula (I). methods of production thereof, and use thereof as medication for the treatment of various diseases.
摘要翻译： 本发明涉及式（I）的磺酰亚胺取代的苯胺基 - 嘧啶衍生物。 其生产方法及其用作治疗各种疾病的药物。
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