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1.发明申请Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 审中-公开取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号：US20060217373A1
公开(公告)日：2006-09-28
申请号：US11443693
申请日：2006-05-30
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/4439 , A61K31/44
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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2.发明申请Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 有权取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号：US20050227972A1
公开(公告)日：2005-10-13
申请号：US10497120
申请日：2002-11-28
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P29/02 , A61P35/00 , A61P43/00 , C07D213/85 , C07D417/12 , C07D417/14 , A61K31/541 , A61K31/444 , A61K31/496 , C07D413/14
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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3.发明授权Substituted 2-thio-3, 5-dicyano-4-phenyl-6-aminopyridines and their use as adenosine receptor-selective ligands 失效取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并将其用作腺苷受体选择配体公开(公告)号：US07045631B2
公开(公告)日：2006-05-16
申请号：US10484133
申请日：2002-07-03
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
IPC分类号： C07D213/62 , C07D417/12
CPC分类号： C07D417/12 , C07D213/85
摘要： Compounds of the formula (I) a process for preparing them, and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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公开(公告)号：US07109218B2
公开(公告)日：2006-09-19
申请号：US10497120
申请日：2002-11-28
申请人： Ulrich Rosentreter , Thomas Krämer , Mitsuyuki Shimada , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Krämer , Mitsuyuki Shimada , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： C07D417/12 , A61K31/4418
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
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5.发明申请Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号：US20070213372A1
公开(公告)日：2007-09-13
申请号：US11607262
申请日：2006-12-01
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R 1〜R 7的定义< SUP>如说明书和权利要求书中所述，涉及含有这种化合物的药物组合物，其制备方法和用作治疗心血管疾病和糖尿病的药物。
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6.发明授权Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号：US08242281B2
公开(公告)日：2012-08-14
申请号：US11607262
申请日：2006-12-01
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： C07D213/72 , C07D213/00 , A01N43/40
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R1-R7的定义如说明书和权利要求中所述，含有 这样的化合物，制备这种材料的方法，以及它们作为用于治疗心血管疾病和糖尿病的药物的用途。
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7.发明申请Substituted 2-oxy-3,5-dicyano-4-aryl-6-aminopyridines and use thereof 失效取代的2-氧基-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US20050261502A1
公开(公告)日：2005-11-24
申请号：US10469556
申请日：2002-02-20
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C07D213/85 , C07D405/04 , C07D409/14 , C07D417/14 , C07D213/84
CPC分类号： C07D405/04 , C07D213/85 , C07D409/14 , C07D417/14
摘要： The use of compounds of formula (I) as medicaments, novel compounds of formula (I) and a method for production thereof are disclosed. Compounds of formula (I) are effective as adenosine receptor ligands.
摘要翻译： 公开了使用式（I）化合物作为药物，新的式（I）化合物及其制备方法。 式（I）化合物作为腺苷受体配体是有效的。
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公开(公告)号：US20060154969A1
公开(公告)日：2006-07-13
申请号：US10471079
申请日：2002-02-28
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D213/84
CPC分类号： C07D401/12 , C07D213/85 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14
摘要： The invention relates to the compounds of formula (I), to a method for producing the same and to the use thereof as medicaments.
摘要翻译： 本发明涉及式（I）化合物，其制备方法及其作为药物的用途。
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9.发明授权Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor 失效取代的2-咔唑-3,5-二氰基-4-芳基-6-氨基吡啶并使用其作为腺苷受体的选择性配体公开(公告)号：US07129255B2
公开(公告)日：2006-10-31
申请号：US10473371
申请日：2002-03-25
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
IPC分类号： A61K31/44 , C07D213/85
CPC分类号： C07D405/04 , C07D213/85
摘要： This application relates to compounds of the formula wherein the groups R1–R6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and to a method of using the same in treatment of cardiovascular disorders.
摘要翻译： 本申请涉及下式的化合物，其中基团R 1〜6 6如说明书和权利要求中所定义，并且含有该化合物的药物组合物，以及 使用该方法治疗心血管疾病的方法。
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10.发明授权Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines with adenosine receptor-binding activity and their use as cardiovascular preparations 失效具有腺苷受体结合活性的取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并将其用作心血管制剂公开(公告)号：US07078417B2
公开(公告)日：2006-07-18
申请号：US10473372
申请日：2002-03-19
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
IPC分类号： A61K31/443 , A61K33/4433 , C07D405/04
CPC分类号： C07D405/04 , C07D213/84 , C07D213/85 , C07D405/14 , C07D417/14
摘要： This application relates to pyridine derivatives having the general structure in which the several variables are as defined in the specification and claims, and to a process for preparing these compounds, a pharmacutical composition containing such compounds, and a method for using these materials for treatment of stable and unstable angina pectoris and atrial fibrillation.
摘要翻译： 本申请涉及具有一般结构的吡啶衍生物，其中几个变量如说明书和权利要求书中所定义，以及制备这些化合物的方法，含有这些化合物的药物组合物，以及使用这些材料用于治疗 稳定和不稳定的心绞痛和心房颤动。
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