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    Multilayered submucosal graft constructs and method for making the same
    3.
    发明授权
    Multilayered submucosal graft constructs and method for making the same 失效
    多层粘膜下移植物构建体及其制备方法

    公开(公告)号：US5955110A

    公开(公告)日：1999-09-21

    申请号：US776490

    申请日：1996-11-12

    申请人： Umesh H. Patel ,  Michael C. Hiles ,  Bryan A. Whitson ,  Boyle Cheng ,  Stephen F. Badylak ,  Klod Kokini

    发明人： Umesh H. Patel ,  Michael C. Hiles ,  Bryan A. Whitson ,  Boyle Cheng ,  Stephen F. Badylak ,  Klod Kokini

    IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/10 ,  A61K35/38 ,  A61L27/36 ,  A61P43/00

    CPC分类号： A61L27/3691 ,  A61F2/0063 ,  A61K35/38 ,  A61L27/3629

    摘要： Multi-laminar tissue graft constructs, pseudoisotropic graft constructs and a method of preparing such constructs are described. Multi-laminar tissue graft constructs are prepared by fusing partially overlapped strips of submucosa tissue into a unitary graft construct by compressing the tissue under dehydrating conditions. Pseudoisotropic tissue graft constructs are prepared by overlapping a first strip of submucosa tissue with at least two strips of submucosa tissue orientated so that the longitudinal axis of each strip formts an angle of about 180.degree./N with the longitudinal axes of at least two other strips of submucosal tissue.

    摘要翻译： PCT No.PCT / US96 / 04721 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT 1996年4月5日PCT公布。 公开号WO96 / 31226 PCT 日期1996年10月10日描述了多层组织移植物构建体，伪各向异性移植物构建体和制备这种构建体的方法。 通过在脱水条件下压缩组织将部分重叠的粘膜下层组织融合成单一移植物构建体来制备多层组织移植物构建体。 通过将粘膜下层组织的第一条带与定向的至少两条粘膜下层组织重叠来制备假性别组织移植物构建体，使得每个条带的纵向轴线与至少两个其它条带的纵向轴线形成约180°/ N的角度 的粘膜下组织。

    Tubular submucosal graft constructs
    4.
    发明授权
    Tubular submucosal graft constructs 有权
    管状粘膜下移植物构建体

    公开(公告)号：US06187039B1

    公开(公告)日：2001-02-13

    申请号：US09297620

    申请日：1999-05-04

    申请人： Michael C. Hiles ,  Umesh H. Patel ,  Leslie A. Geddes ,  Stephen F. Badylak

    发明人： Michael C. Hiles ,  Umesh H. Patel ,  Leslie A. Geddes ,  Stephen F. Badylak

    IPC分类号： A60F206

    CPC分类号： A61L27/3604 ,  A61F2/06 ,  A61F2310/00365 ,  A61L27/24 ,  A61L27/3629 ,  A61L27/3687

    摘要： An easy-to-produce and mechanically strong tube of an implantable submucosal tissue has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the submucosal tissue prosthesis generally involves wrapping a first sheet of submucosal tissue (60) and a second sheet of submucosal tissue (70) around a mandrel (50), wherein the first end (74) and the second opposite end (76) of the second sheet of submucosal tissue (70) are sutured together with sutures (78). The submucosal tissue is compressed and dried on the mandrel (50) before removing the construct by pulling on a first end (54) and a second end (56) of a water permeable tape to unwind the tape and thus release the construct for eventual use.

    摘要翻译： 已经开发了可植入的粘膜下组织的容易制造和机械强度的管，其以任何期望的长度，壁厚或直径制造。 通过本发明的方法生产的构造体可以用作动脉，静脉，输尿管，尿道，分流器的移植物，或者在需要顺应的组织相容管的任何应用中。 粘膜下组织假体的制造通常包括围绕心轴（50）缠绕第一片粘膜下组织（60）和第二片粘膜下组织（70），其中第一端（74）和第二相对端（76） ）的第二片粘膜下组织（70）与缝合线（78）缝合在一起。 在通过拉动透水性带的第一端（54）和第二端（56）去除构造物之前，在心轴（50）上压缩并干燥粘膜下组织以展开带，并因此释放结构以最终使用 。

    Method of repairing perforated submucosal tissue graft constructs
    5.
    发明授权
    Method of repairing perforated submucosal tissue graft constructs 失效
    修复穿孔粘膜下组织移植物构建体的方法

    公开(公告)号：US5968096A

    公开(公告)日：1999-10-19

    申请号：US908151

    申请日：1997-08-06

    申请人： Bryan Whitson ,  Boyle Cheng ,  Stephen F. Badylak

    发明人： Bryan Whitson ,  Boyle Cheng ,  Stephen F. Badylak

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61L27/36 ,  A61F2/10 ,  A61K35/38

    CPC分类号： A61L27/3683 ,  A61F2/02 ,  A61L27/3629 ,  A61F2240/001

    摘要： A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.

    摘要翻译： 描述了一种穿孔单层多层组织移植物构建体及其制备方法。 该方法包括将粘膜下层组织与其它粘膜下组织条带重叠，在允许或促进压缩粘膜下层片脱水的条件下至少压缩两个表面的两个表面的重叠部分，并对所得的单一组织移植物构件进行穿孔。 穿孔组织移植组合物相对于非穿孔粘膜下组织移植物具有增强的机械和重塑性能。

    Perforated submucosal tissue graft constructs
    7.
    发明授权
    Perforated submucosal tissue graft constructs 失效
    穿孔粘膜下组织移植物构建体

    公开(公告)号：US05997575A

    公开(公告)日：1999-12-07

    申请号：US932868

    申请日：1997-09-18

    申请人： Bryan Whitson ,  Boyle Cheng ,  Stephen F. Badylak

    发明人： Bryan Whitson ,  Boyle Cheng ,  Stephen F. Badylak

    IPC分类号： A61F2/00 ,  A61F2/02 ,  A61L27/36 ,  A61F2/10

    CPC分类号： A61L27/3683 ,  A61F2/02 ,  A61L27/3629 ,  A61F2240/001

    摘要： A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.

    摘要翻译： 描述了一种穿孔单层多层组织移植物构建体及其制备方法。 该方法包括将粘膜下层组织与其它粘膜下组织条带重叠，在允许或促进压缩粘膜下层片脱水的条件下至少压缩两个表面的两个表面的重叠部分，并对所得的单一组织移植物构件进行穿孔。 穿孔组织移植组合物相对于非穿孔粘膜下组织移植物具有增强的机械和重塑性能。

    Extracellular matrix based gastroesophageal junction reinforcement device
    10.
    发明授权
    Extracellular matrix based gastroesophageal junction reinforcement device 有权
    基于细胞外基质的胃食管结合加强装置

    公开(公告)号：US08927003B2

    公开(公告)日：2015-01-06

    申请号：US13108074

    申请日：2011-05-16

    申请人： Stephen F. Badylak ,  Thomas W. Gilbert ,  Alejandro Nieponice

    发明人： Stephen F. Badylak ,  Thomas W. Gilbert ,  Alejandro Nieponice

    IPC分类号： A61L27/36 ,  A61K35/38 ,  A61L27/38

    CPC分类号： A61L27/3679 ,  A61F2/04 ,  A61F2002/044 ,  A61K35/38 ,  A61L27/362 ,  A61L27/3629 ,  A61L27/3633 ,  A61L27/3882 ,  A61L2430/22

    摘要： Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.

    摘要翻译： 提供用于植入患有至少部分食管的患者的医疗装置。 医疗装置将食道或其余部分与胃连接以形成胃食管连接处，其在分配负荷并减少吻合部位的张力的同时促进愈合并促进新的宿主组织生长。 医疗装置包括细胞外基质成形为更接近天然胃食管结合物的几何形状的构象，而不是将胃直接附着于缩短的食道。 在本文中还描述了用于制造医疗装置的模具和装置的使用方法。