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公开(公告)号:US20170226472A1
公开(公告)日:2017-08-10
申请号:US15501718
申请日:2015-08-04
发明人: Juan Antonio Marchal Corrales , Gema Jiménez González , Cynthia Morata Tarifa , María Ángel García Chaves , Macarena Perán Quesada
CPC分类号: C12N5/0037 , C12N5/0695 , C12N2500/90 , C12N2501/10 , C12N2501/11 , C12N2501/113 , C12N2501/12 , C12N2501/165 , C12N2501/22 , C12N2501/2306 , C12N2501/2308 , C12N2501/2312 , C12N2501/2323 , C12N2501/33 , C12N2501/39 , C12N2501/91 , C12N2501/999 , C12N2509/00
摘要: The present invention relates to a serum-free conditioned medium that solves the drawbacks mentioned in the prior art, as it does not require prior handling of the cells, and it furthermore allows starting from a large population with no additional cost. This medium favors in vitro proliferation and conservation of the pluripotency potential that allows maintaining a state that is undifferentiated with respect to the subpopulation of cancer stem cells (CSCs) and in turn does not allow survival of the differentiated cells.