公开(公告)号：US20210030676A1

公开(公告)日：2021-02-04

申请号：US16966626

申请日：2019-01-31

Applicant: Universität Basel ,  Universität Freiburg

Inventor： Bert MÜLLER ,  Andreas ZUMBÜHL ,  Thomas PFOHL ,  Dennis MÜLLER ,  Frederik NEUHAUS ,  Radu TANASESCU ,  Till SAXER ,  Marzia BUSCEMA ,  Sofiya MATVIYKIV ,  Gabriela GERGANOVA

IPC: A61K9/127 ,  A61K47/24 ,  A61K47/44

Abstract: A liposome vesicle comprising a membrane consisting of 1,3-diheptadecanamidopropan-2-yl(2-(trimethylammonio)ethyl)phosphate surrounding a volume comprising a pharmaceutical drug or contrast agent. The vesicle is mechanosensitive at body temperature and at physiologically or pathophysiologically relevant shear stress.

公开(公告)号：US20240226540A1

公开(公告)日：2024-07-11

申请号：US18559377

申请日：2022-05-06

Applicant: Universität Basel Vizerektorat Forschung

Inventor： Bekim OSMANI ,  Tino TÖPPER ,  Bert MÜLLER ,  Carina LUCHSINGER SALINAS ,  Raphael GUZMAN ,  Alois HOPF ,  Mahyar JOODAKI

IPC: A61N1/05

CPC classification number: A61N1/0551

Abstract: A novel ultra-thin neural implant (1) is provided that is based on a cellulose thin film (4) featuring an array (2) of electrodes (3). Due to the use of cellulose as the base material, the implant (1) can be safely handled during a micro-surgery, despite its high softness and conformability. Such an implant (1) may be useful in numerous applications ranging from electrical stimulation in neural prostheses, electro-stimulated regeneration of neural tissue to accurate recording of nerve signals. The robustness of the implant (1) results from a woven fabric (5) that is integrated in the cellulose carrier thin film (4). Several approaches for enhancing the tissue compatibility of the implant (1) are also provided.

公开(公告)号：US20210041310A1

公开(公告)日：2021-02-11

申请号：US16976908

申请日：2019-03-01

Applicant: UNIVERSITÄT BASEL VIZEREKTORAT FORSCHUNG

Inventor： Tino TÖPPER ,  Bekim OSMANI ,  Bert MÜLLER

IPC: G01L1/14 ,  H01L41/193 ,  H01L41/09 ,  H01L41/45

Abstract: For improving the sensitivity, lifetime and energy consumption of a dielectric elastomer transducer (1) to be used as a sensor, it is suggested that a dielectric layer (3) enclosed by two electrodes (2) of the transducer (1) includes a nanoscale volume of a fluid (15) such that the dielectric layer (3) is rendered compressible and/or displaceable out of a volume enclosed by the two electrodes (2). The advantage of such a design is that, although the dielectric layer (3) and possible buffer layers (4) separating the electrodes (2) from the dielectric layer (3) may all have thicknesses in the order of a few μm or even in the sub-μm range, the transducer (1) is rendered highly compliant due to the movability of the fluid (15). In consequence, a large nominal capacitance of the transducer (1) as well as a large relative capacitance change (up to twenty times that of the nominal capacitance) can be achieved in conjunction with a very high sensitivity.