公开(公告)号：US09731001B2

公开(公告)日：2017-08-15

申请号：US14367741

申请日：2012-12-20

申请人： Universite Laval

发明人： Caroline Gilbert ,  Michel J. Tremblay ,  Sheng-Xiang Lin ,  Arezki Azzi ,  Alexandra Lambert

IPC分类号： A61K31/40 ,  A61K31/34 ,  A61K31/13 ,  A61K39/21 ,  A61K31/12 ,  A61K31/343 ,  A61K31/352 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/501 ,  A61K31/655 ,  C40B30/02 ,  C07K14/705 ,  C07C49/796 ,  C07C291/08 ,  C07D215/58 ,  C07D257/04 ,  C07D271/12 ,  C07D277/64 ,  C07D307/79 ,  C07D307/80 ,  C07D311/82 ,  C07D401/04 ,  C07D401/14 ,  C07D405/06 ,  C07D417/14

CPC分类号： A61K39/21 ,  A61K31/12 ,  A61K31/343 ,  A61K31/352 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/501 ,  A61K31/655 ,  C07C49/796 ,  C07C291/08 ,  C07D215/58 ,  C07D257/04 ,  C07D271/12 ,  C07D277/64 ,  C07D307/79 ,  C07D307/80 ,  C07D311/82 ,  C07D401/04 ,  C07D401/14 ,  C07D405/06 ,  C07D417/14 ,  C07K14/7056 ,  C40B30/02

摘要： The invention is concerned with compounds, pharmaceutical compositions, screening methods, and therapeutic methods for preventing or reducing a human immunodeficiency virus type-1 (HIV-1) infection and/or propagation associated with dendritic cell immunoreceptor (DCIR). Described herein are compounds which bind on at least one three-dimensional cavity of the DCIR, the cavity(ies) being involved in the interaction between HIV-1 and DCIR. Also described are screening methods for identifying active inhibitors and method of using such inhibitors for the prevention or treatment of virus infections, and more particularly for reducing human immunodeficiency virus type-1 (HIV-1) binding, entry and/or replication in human cells.

公开(公告)号：US20150157705A1

公开(公告)日：2015-06-11

申请号：US14367741

申请日：2012-12-20

申请人： Universite Laval

发明人： Caroline Gilbert ,  Michel J. Tremblay ,  Sheng-Xiang Lin ,  Arezki Azzi ,  Alexandra Lambert

IPC分类号： A61K39/21 ,  C07D215/58 ,  C07D417/14 ,  C07D401/14 ,  C07D311/82 ,  C07D307/79 ,  C07D277/64 ,  C07D271/12 ,  C07D401/04 ,  C07D307/80 ,  C07C291/08 ,  C07D405/06 ,  C07C49/796 ,  C07D257/04

CPC分类号： A61K39/21 ,  A61K31/12 ,  A61K31/343 ,  A61K31/352 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/501 ,  A61K31/655 ,  C07C49/796 ,  C07C291/08 ,  C07D215/58 ,  C07D257/04 ,  C07D271/12 ,  C07D277/64 ,  C07D307/79 ,  C07D307/80 ,  C07D311/82 ,  C07D401/04 ,  C07D401/14 ,  C07D405/06 ,  C07D417/14 ,  C07K14/7056 ,  C40B30/02

摘要： The invention is concerned with compounds, pharmaceutical compositions, screening methods, and therapeutic methods for preventing or reducing a human immunodeficiency virus type-1 (HIV-1) infection and/or propagation associated with dendritic cell immunoreceptor (DCIR). Described herein are compounds which bind on at least one three-dimensional cavity of the DCIR, the cavity(ies) being involved in the interaction between HIV-1 and DCIR. Also described are screening methods for identifying active inhibitors and method of using such inhibitors for the prevention or treatment of virus infections, and more particularly for reducing human immunodeficiency virus type-1 (HIV-1) binding, entry and/or replication in human cells.

摘要翻译： 本发明涉及用于预防或减少与免疫受体（DCIR）相关的人类免疫缺陷病毒1型（HIV-1）感染和/或传播的化合物，药物组合物，筛选方法和治疗方法。 本文描述的是结合在DCIR的至少一个三维空腔上的化合物，所述空腔涉及HIV-1和DCIR之间的相互作用。 还描述了用于鉴定活性抑制剂的筛选方法和使用这种抑制剂来预防或治疗病毒感染的方法，更具体地说是减少人类免疫缺陷病毒1型（HIV-1）结合，进入和/或复制的方法 。