公开(公告)号：US20170051023A1

公开(公告)日：2017-02-23

申请号：US15243409

申请日：2016-08-22

Applicant: University of Exeter

Inventor： Richard W. Titball ,  Sergio Paulo Fernandes Da Costa ,  Claire Naylor ,  Ajit Basak

IPC: C07K14/33 ,  C12N7/00

CPC classification number: C07K14/33 ,  A61K39/08 ,  A61K2039/552 ,  A61K2039/575 ,  A61K2039/6006

Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

Abstract translation: 提供了包含SEQ ID NO：1的至少10个连续氨基酸的NetB表位多肽，并且与SEQ ID NO：3中的等同位置相比，在氨基酸130和297之间的至少一个位置具有突变，突变 优选地位于边缘结构域内，所述多肽能够结合与SEQ ID NO：1结合的抗体，并且与SEQ ID NO：1的毒性相比具有降低的毒性。 该多肽可用于使受试者免疫产气荚膜梭菌感染。

公开(公告)号：US10174086B2

公开(公告)日：2019-01-08

申请号：US15243409

申请日：2016-08-22

Applicant: University of Exeter

Inventor： Richard W. Titball ,  Sergio Paulo Fernandes Da Costa ,  Claire Naylor ,  Ajit Basak

IPC: C07H21/02 ,  C07H21/04 ,  C07K14/33 ,  A61K39/08 ,  A61K39/00

Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

公开(公告)号：US20160310587A1

公开(公告)日：2016-10-27

申请号：US15106199

申请日：2014-12-18

Applicant: University of Exeter ,  Universiteit Gent

Inventor： Richard William Titball ,  Sergio Paulo Fernandes Da Costa ,  Filip Van Immerseel ,  Richard Ducatelle ,  Dorien Mot

IPC: A61K39/08 ,  C07K14/33

CPC classification number: A61K39/08 ,  A61K2039/552 ,  C07K14/33

Abstract: The invention provides a composition comprising a reduced toxicity NetB epitope polypeptide and a reduced toxicity Clostridium perfringens alpha-toxin epitope polypeptide. The composition is useful as a vaccine providing complete protection against infection by C. perfringens.

Abstract translation: 本发明提供了包含降低毒性的NetB表位多肽和降低毒性的产气荚膜梭菌α-毒素表位多肽的组合物。 该组合物可用作提供完全防止产气荚膜梭菌感染的疫苗。