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    VACCINE
    1.
    发明申请
    VACCINE 有权
    疫苗

    公开(公告)号：US20140302094A1

    公开(公告)日：2014-10-09

    申请号：US14354117

    申请日：2012-10-24

    Applicant: university of Exeter

    Inventor： Richard W. Titball ,  Sérgio Paulo Fernandes Da Costa ,  Claire Naylor ,  Ajit Basak

    IPC: C07K14/33

    CPC classification number: C07K14/33 ,  A61K38/00 ,  A61K38/4893 ,  A61K39/00 ,  A61K39/08 ,  A61K2039/552 ,  C07K7/06 ,  C07K14/47

    Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

    Abstract translation: 提供了包含SEQ ID NO：1的至少10个连续氨基酸的NetB表位多肽，并且在SEQ ID NO：1中与SEQ ID中的等同位置相比，其突变位于氨基酸130和297之间的至少一个位置，优选位于 边缘结构域，所述多肽能够结合与SEQ ID NO：1结合的抗体，并且与SEQ ID NO：1的毒性相比具有降低的毒性。 该多肽可用于使受试者免疫产气荚膜梭菌感染。

    Vaccine
    2.
    发明授权
    Vaccine 有权

    公开(公告)号：US10174086B2

    公开(公告)日：2019-01-08

    申请号：US15243409

    申请日：2016-08-22

    Applicant: University of Exeter

    Inventor： Richard W. Titball ,  Sergio Paulo Fernandes Da Costa ,  Claire Naylor ,  Ajit Basak

    IPC: C07H21/02 ,  C07H21/04 ,  C07K14/33 ,  A61K39/08 ,  A61K39/00

    Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

    VACCINE
    3.
    发明申请
    VACCINE 审中-公开
    疫苗

    公开(公告)号：US20170051023A1

    公开(公告)日：2017-02-23

    申请号：US15243409

    申请日：2016-08-22

    Applicant: University of Exeter

    Inventor： Richard W. Titball ,  Sergio Paulo Fernandes Da Costa ,  Claire Naylor ,  Ajit Basak

    IPC: C07K14/33 ,  C12N7/00

    CPC classification number: C07K14/33 ,  A61K39/08 ,  A61K2039/552 ,  A61K2039/575 ,  A61K2039/6006

    Abstract: There is provided a NetB epitope polypeptide comprising at least 10 contiguous amino acids from SEQ ID NO:1 and comprising a mutation in at least one position between amino acids 130 and 297 as compared with the equivalent position in SEQ ID NO:3, the mutation preferably being located within a rim domain, the polypeptide being capable of binding an antibody which binds to SEQ ID NO:1 and having reduced toxicity compared with the toxicity of SEQ ID NO:1. The polypeptide is useful to vaccinate a subject against infection by Clostridium perfringens.

    Abstract translation: 提供了包含SEQ ID NO：1的至少10个连续氨基酸的NetB表位多肽，并且与SEQ ID NO：3中的等同位置相比，在氨基酸130和297之间的至少一个位置具有突变，突变 优选地位于边缘结构域内，所述多肽能够结合与SEQ ID NO：1结合的抗体，并且与SEQ ID NO：1的毒性相比具有降低的毒性。 该多肽可用于使受试者免疫产气荚膜梭菌感染。

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