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    METHODS FOR CANCER SCREENING AND MONITORING BY CANCER MASTER REGULATORS MARKERS IN LIQUID BIOPSY
    2.
    发明申请
    METHODS FOR CANCER SCREENING AND MONITORING BY CANCER MASTER REGULATORS MARKERS IN LIQUID BIOPSY 有权

    公开(公告)号：US20220119892A1

    公开(公告)日：2022-04-21

    申请号：US17428475

    申请日：2020-02-06

    申请人： University of Florida Research Foundation, Incorporated

    发明人： David Tran ,  Son Bang Le

    IPC分类号： C12Q1/6886

    摘要： Provided herein are methods of assessing, detecting, monitoring the presence, or monitoring progression of cancer in a subject, or assessing or predicting prognosis or survival of a subject having cancer. Also provided are methods of measuring chromosomal accessibility of the chromosomal locus of cancer master regulator genes or downstream genes in the master regulator network, methods of measuring chromosomal DNA methylation at the chromosomal locus of cancer master regulator genes or downstream genes, and methods measuring chromosomal DNA methylation at the chromosomal locus of the promoter and/or regulatory regions of cancer master regulator genes or downstream genes.

    Molecular cell diary system
    3.
    发明授权
    Molecular cell diary system 有权

    公开(公告)号：US11447768B2

    公开(公告)日：2022-09-20

    申请号：US16078272

    申请日：2017-03-01

    申请人： University of Florida Research Foundation, Incorporated

    发明人： David Tran ,  Son Le

    IPC分类号： A01N63/00 ,  C07H21/04 ,  C12N15/10 ,  C12N15/85 ,  C12N15/90 ,  A01K67/027 ,  C12N15/63 ,  C12N9/12 ,  C12N9/22 ,  C12Q1/6886

    摘要： The subject invention pertains to a Molecular Cell Diary System (MCDS), which allows identification of the history of somatic alterations in the cell. MCDS comprises one or more combinations of a DNA cutter and a DNA writer expressed under the control of a promoter controlled a cellular event of interest. The DNA cutter and the DNA writer are in a combination are co-expressed when an even of interest occurs. The DNA cutter creates double strand breaks (DSB) in a target DNA in a sequence specific manner and the DNA writer incorporates DNA sequences in the DSB. The endogenous DNA repair machinery synthesizes repairs the DSB. As such, the combination of the DNA cutter and the DNA writer modifies the target DNA and leaves “marks” of the occurrence of the cellular event of interest. These marks are sequenced and the cellular event history of the cell is deciphered.

    Core Master Regulators Of Glioblastoma Stem Cells
    4.
    发明申请
    Core Master Regulators Of Glioblastoma Stem Cells 审中-公开

    公开(公告)号：US20200165614A1

    公开(公告)日：2020-05-28

    申请号：US16613402

    申请日：2018-05-15

    申请人： University of Florida Research Foundation, Incorporated

    发明人： David Tran ,  Son B. Le

    IPC分类号： C12N15/113

    摘要： Provided herein are immunotherapy compositions for treating a subject with a glioblastoma, comprising a peptide formulation derived from at least one cancer or sternness factor, nanoparticles containing peptides derived from at least one cancer or sternness factor, dendritic cells containing peptides derived from at least one cancer or sternness factors, RNA coding at least one cancer or sternness factor, nanoparticles containing RNA coding at least one cancer or sternness factor, dendritic cells containing RNA coding at least one cancer factor or sternness factor, or an inhibitor of at least one cancer or sternness factor. Also provided are methods of inhibiting a glioblastoma stem-like cell (GSC), methods of treating a subject for glioblastoma, and methods of reprogramming an astrocyte to a glioblastoma stem-like cell (GSC) using such immunotherapy compositions.

    Core master regulators of glioblastoma stem cells
    6.
    发明授权
    Core master regulators of glioblastoma stem cells 有权

    公开(公告)号：US11827884B2

    公开(公告)日：2023-11-28

    申请号：US16613402

    申请日：2018-05-15

    申请人： University of Florida Research Foundation, Incorporated

    发明人： David Tran ,  Son B. Le

    IPC分类号： C12N15/113 ,  A61K45/06

    CPC分类号： C12N15/1135 ,  A61K45/06 ,  C12N2310/14 ,  C12N2310/531

    摘要： Provided herein are immunotherapy compositions for treating a subject with a glioblastoma, comprising a peptide formulation derived from at least one cancer or stemness factor, nanoparticles containing peptides derived from at least one cancer or stemness factor, dendritic cells containing peptides derived from at least one cancer or stemness factors, RNA coding at least one cancer or stemness factor, nanoparticles containing RNA coding at least one cancer or stemness factor, dendritic cells containing RNA coding at least one cancer factor or stemness factor, or an inhibitor of at least one cancer or stemness factor. Also provided are methods of inhibiting a glioblastoma stem-like cell (GSC), methods of treating a subject for glioblastoma, and methods of reprogramming an astrocyte to a glioblastoma stem-like cell (GSC) using such immunotherapy compositions.

    CHEMOTHERAPEUTIC METHODS
    10.
    发明申请
    CHEMOTHERAPEUTIC METHODS 审中-公开

    公开(公告)号：US20200237728A1

    公开(公告)日：2020-07-30

    申请号：US16845672

    申请日：2020-04-10

    申请人： University of Florida Research Foundation, Incorporated

    发明人： David Tran

    IPC分类号： A61K31/421 ,  A61K39/395 ,  A61K45/06 ,  A61K31/12 ,  A61P35/00

    摘要： Disclosed herein are chemotherapeutic methods for the treatment of cancer in humans. In at least one specific embodiment, the method can include administering a therapeutic effective amount of one or more p38 inhibitor compound or salt thereof to a human. The method can also include administering a therapeutic effective of one or more IL-6 inhibitor or one or more IL-6 receptor inhibitor or salt thereof to the human. The method can also include administering a therapeutic effective amount of one or more cytotoxic compound or salt thereof to the human.