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公开(公告)号:US20220396809A1
公开(公告)日:2022-12-15
申请号:US17831894
申请日:2022-06-03
申请人: University of Guelph
发明人: Sarah Wootton , Leonardo Susta , Byram Bridle , Pierre Major , Lisa Santry , Yanlong Pei
IPC分类号: C12N15/86 , C07K14/005 , A61K39/17 , A61K39/215 , A61P35/00 , A61P31/14
摘要: An engineered Newcastle Disease Virus (NDV) vector is provided. In particular, the present disclosure provides methods of treating or preventing a disease such as cancer, or an infectious disease, or methods for eliciting an immune response, with the engineered NDV vector. The engineered NDV vector provided herein is useful as an immunogenic composition, an oncolytic agent, or a vaccine.
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公开(公告)号:US20190216949A1
公开(公告)日:2019-07-18
申请号:US16251119
申请日:2019-01-18
摘要: A recombinant adeno-associated virus (rAAV) particle with a mutated capsid protein is provided. In particular, the present disclosure provides methods of delivering a therapeutic agent to a muscle, airway, liver, central nervous system, retina or lung cell in a subject, and methods of treating or preventing infectious, acquired or genetic disease, with said rAAV particle.
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公开(公告)号:US10806802B2
公开(公告)日:2020-10-20
申请号:US16251119
申请日:2019-01-18
摘要: A recombinant adeno-associated virus (rAAV) particle with a mutated capsid protein is provided. In particular, the present disclosure provides methods of delivering a therapeutic agent to a muscle, airway, liver, central nervous system, retina or lung cell in a subject, and methods of treating or preventing infectious, acquired or genetic disease, with said rAAV particle.
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