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公开(公告)号：US20230332192A1
公开(公告)日：2023-10-19
申请号：US18025056
申请日：2021-03-23
申请人： DAESANG CORPORATION
发明人： Dong Seok LEE , Min Jin CHOI , Moon Jeong KIM , Seok Hyun PARK , Jae Chun HAN
CPC分类号： C12P13/10 , C12N1/20 , C12N15/77 , C12R2001/15
摘要： The present invention relates to a Corynebacterium glutamicum mutant strain having increased L-citrulline productivity and a method of producing L-citrulline using the same. The Corynebacterium glutamicum mutant strain is capable of producing L-citrulline in high yield and high concentration because the activity of the transport protein that is expressed by the NCgl2816 gene therein has been weakened or inactivated.
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公开(公告)号：US09873898B2
公开(公告)日：2018-01-23
申请号：US15082274
申请日：2016-03-28
申请人： AJINOMOTO CO., INC.
IPC分类号： C12P13/24 , C12N15/00 , C12Q1/68 , C07H21/04 , C07K1/00 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/22 , C07K14/24 , C12N1/20 , C12P13/04
CPC分类号： C12P13/24 , C07K14/24 , C12N1/20 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/222 , C12P13/227
摘要： The present invention provides a method for producing an L-amino acid by fermentation using a bacterium of the family Enterobacteriaceae. The bacterium can belong to the genus Escherichia, which has been modified to attenuate expression of a phosphate transporter-encoding gene, such as the pitA gene or pitB gene.
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公开(公告)号：US20170258796A1
公开(公告)日：2017-09-14
申请号：US15438244
申请日：2017-02-21
发明人： Louis M. Messina
IPC分类号： A61K31/519 , A61K31/375 , A61K31/198
CPC分类号： A61K31/519 , A61K31/198 , A61K31/375 , A61K31/495 , A61K35/13 , A61K45/06 , A61K48/005 , A61K2300/00 , C12N2799/022 , C12P13/10
摘要： The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
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公开(公告)号：US09567616B2
公开(公告)日：2017-02-14
申请号：US13983917
申请日：2012-02-09
申请人： Tetsuro Ujihara , Tetsuya Abe , Makoto Yagasaki
发明人： Tetsuro Ujihara , Tetsuya Abe , Makoto Yagasaki
CPC分类号： C12P13/10 , C12N1/20 , C12N9/1205 , C12P13/04 , C12P13/08 , C12Y207/01069 , C12Y207/03009 , Y02P20/52
摘要： A target substance can be efficiently produced by culturing, in a medium, a coryneform bacterium in which the activity of a PTS protein relating to fructose uptake is reduced or lost as compared with a parent strain and the bacterium can produce the target substance, allowing the target substance to form and accumulate in a culture; and collecting the target substance from the culture.
摘要翻译： 通过在培养基中培养与亲本菌株相比，与果糖摄取相关的PTS蛋白质的活性降低或丧失的棒状细菌，可以有效地产生目标物质，并且细菌可以产生目标物质，允许 目标物质在文化中形成和积累; 并从文化中收集目标物质。
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公开(公告)号：US20160177274A1
公开(公告)日：2016-06-23
申请号：US14960333
申请日：2015-12-04
申请人： SYNLOGIC, INC.
IPC分类号： C12N9/10 , A61K35/741
CPC分类号： C12N9/1029 , A61K35/741 , C07K14/245 , C12N9/1025 , C12N15/52 , C12N15/70 , C12P13/10 , C12R1/01 , C12R1/19 , C12Y203/01001
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating disorders associated with hyperammonemia are disclosed.
摘要翻译： 公开了遗传工程细菌，其药物组合物，以及调节和治疗与高氨血症相关的疾病的方法。
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公开(公告)号：US09334512B2
公开(公告)日：2016-05-10
申请号：US14483611
申请日：2014-09-11
申请人： AJINOMOTO CO., INC.
发明人： Ryo Takeshita , Shinichi Sugimoto
摘要： A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter ions of the basic substance is reduced by adjusting total ammonia concentration in the medium to be within a specific concentration range during at least a part of the total period of culture process.
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公开(公告)号：US20160053335A1
公开(公告)日：2016-02-25
申请号：US14762840
申请日：2014-01-13
申请人： Marcus PERSICKE , Frederik WALTER , Jörn KALINOWSKI , Andrea HÜSER , Alexander RETH , EVONIK DEGUSSA GMBH
发明人： Frederik Walter , Marcus Persicke , Jörn Kalinowski , Andrea Hüser , Wilfried Claes , Alexander Reth
CPC分类号： C12R1/15 , C12N9/0036 , C12N9/0051 , C12P7/40 , C12P13/001 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/227 , C12P13/24 , C12P19/30 , C12P19/38
摘要： The invention relates to a microorganism that produces and/or secretes an organic chemical compound, wherein the microorganism has an increased expression, compared to the respective starting strain, of a polypeptide LpdA with the activity of a transhydrogenase; and a process for producing an organic chemical compound using the microorganism according to the invention.
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8.发明申请Method for Producing an L-Amino Acid Using a Bacterium of the Enterobacteriaceae Family 审中-公开使用肠杆菌科的细菌生产L-氨基酸的方法公开(公告)号：US20150203881A1
公开(公告)日：2015-07-23
申请号：US14668080
申请日：2015-03-25
申请人： AJINOMOTO CO., INC.
发明人： Leonid Romanovich Ptitsyn , Irina Borisovna Altman , Veronika Aleksandrovna Kotliarova , Olga Nikolaevna Mokhova , Tatyana Abramovna Yampolskaya , Yury Ivanovich Kozlov , Masaru Terashita , Yoshihiro Usuda , Kazuhiko Matsui
CPC分类号： C12P13/08 , C12N9/0006 , C12P13/04 , C12P13/06 , C12P13/10 , C12P13/14 , C12P13/222 , C12P13/227 , C12P13/24 , C12Y101/01002
摘要： A method for producing an L-amino acid is described, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan, or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of a wild-type alcohol dehydrogenase encoded by the adhE gene or a mutant alcohol dehydrogenase which is resistant to aerobic inactivation.
摘要翻译： 例如使用肠杆菌科的细菌来描述L-氨基酸的制造方法，例如L-苏氨酸，L-赖氨酸，L-组氨酸，L-苯丙氨酸，L-精氨酸，L-色氨酸或L-谷氨酸 家族，其中细菌已经被修饰以增强由adhE基因编码的野生型醇脱氢酶的活性或对有氧失活有抗性的突变型醇脱氢酶。
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公开(公告)号：US20150065514A1
公开(公告)日：2015-03-05
申请号：US14535690
申请日：2014-11-07
发明人： Louis M. Messina
IPC分类号： A61K31/519 , A61K31/375 , A61K31/198
CPC分类号： A61K31/519 , A61K31/198 , A61K31/375 , A61K31/495 , A61K35/13 , A61K45/06 , A61K48/005 , C12N2799/022 , C12P13/10 , A61K2300/00
摘要： The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells in vivo or in vitro.
摘要翻译： 本发明涉及用于降低体内或体外细胞氧化应激水平的组合物的治疗应用。 本发明描述了改善干细胞治疗性质的方法。 本发明还提供了用于平衡体内或体外细胞的氧化微环境的组合疗法。
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公开(公告)号：US08969048B2
公开(公告)日：2015-03-03
申请号：US14268110
申请日：2014-05-02
申请人： Ajinomoto Co., Inc.
发明人： Yury Ivanovich Kozlov , Akito Chinen , Hiroshi Izui , Yoshihiko Hara , Hisashi Yasueda , Konstantin Vyacheslavovich Rybak , Ekaterina Aleksandrovna Slivinskaya , Joanna Yosifovna Katashkina
IPC分类号： C12P13/24 , C12N9/88 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/14 , C12P7/44 , C12P13/12 , C12P13/20 , C12P7/42
CPC分类号： C12P13/24 , C12N9/88 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/62 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/20 , C12Y401/02009 , C12Y401/02022
摘要： The present invention provides a bacterium which has an ability to produce a useful metabolite derived from acetyl-coenzyme A, such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, L-cysteine, succinate, and polyhydroxybutyrate, wherein said bacterium is modified so that activities of D-xylulose-5-phosphate phosphoketolase and/or fructose-6-phosphate phosphoketolase are enhanced. The present invention also provides a method for producing the useful metabolite using the bacterium.
摘要翻译： 本发明提供一种具有生产乙酰辅酶A的有用代谢物的能力，例如L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-精氨酸，L-亮氨酸，L-半胱氨酸，琥珀酸酯 和聚羟基丁酸酯，其中所述细菌被修饰，使得D-木酮糖-5-磷酸磷酸酮糖苷酶和/或果糖-6-磷酸磷酸酮醇酶的活性增强。 本发明还提供了使用该细菌生产有用代谢物的方法。
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