公开(公告)号：US20020155145A1

公开(公告)日：2002-10-24

申请号：US10164580

申请日：2002-06-10

Applicant: University of Nottingham

Inventor： Steven Melvyn Howdle ,  Vladimir Popov

IPC: A61F002/00

CPC classification number: B05D3/0446 ,  A61K6/033 ,  A61K6/08 ,  A61K6/083 ,  A61K6/087 ,  A61K9/1694 ,  A61L27/44 ,  A61L27/50 ,  B05D7/02 ,  B05D2401/90

Abstract: Process for the preparation of a composition comprising a biofunctional polymer substrate and biofunctional material substrate adapted for use in or in association with the human or animal body, cultivated or uncultivated living matter, wherein the biofunctional material substrate is substantially insoluble in the polymer substrate and/or a supercritical fluid, wherein the process comprises contacting a mixture of the substrates or their precursors with a supercritical fluid under supercritical conditions and conditions of reduced viscosity and physical blending to plasticise and swell the polymer and distribute the biofunctional material substrate throughout the polymer, and releasing the fluid under subcritical conditions, wherein the substrates are adapted to be isolated in form of a solid admixture comprising the biofunctional material substrate in substantially unchanged chemical form, and in substantially unchanged physical form, composition obtained thereby, polymer matrix embodiment thereof and the process for its preparation.

Abstract translation: 用于制备包含生物功能性聚合物底物和生物功能材料底物的组合物的方法，所述底物适于在人体或动物身体，培养或未培养的生物中使用或与其结合使用，其中生物功能材料基质基本上不溶于聚合物基质和/ 或超临界流体，其中所述方法包括在超临界条件和粘度降低和物理共混的条件下使基质或其前体的混合物与超临界流体接触，以使聚合物塑化和溶胀并将生物功能材料基材分布在整个聚合物上，以及 在亚临界条件下释放流体，其中基质适于以基本上不变的化学形式包含生物功能材料基质的固体混合物的形式分离，并且以基本上不变的物理形式，由此获得的组合物，聚合物基体体现 其制备方法及其制备方法。