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1.发明公开公开(公告)号：US20240325565A1
公开(公告)日：2024-10-03
申请号：US18624989
申请日：2024-04-02
发明人： Song Li , Jingjing Sun
IPC分类号： A61K47/69 , A61K39/395 , A61K47/58 , A61K47/60
CPC分类号： A61K47/6925 , A61K39/3955 , A61K47/58 , A61K47/60 , B82Y5/00
摘要： A formulation including a nanostructure including an agent to activate a STING pathway in vivo and a C-C chemokine receptor type 2 (CCR2) antagonist.
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公开(公告)号：US11857634B2
公开(公告)日：2024-01-02
申请号：US17049152
申请日：2019-04-20
发明人： Song Li , Jingjing Sun , Yichao Chen , Yixian Huang , Yanhua Liu , Binfeng Lu
IPC分类号： A61K47/58 , A61K47/54 , A61K9/107 , A61K31/65 , C12N15/113
CPC分类号： A61K47/58 , A61K9/1075 , A61K31/65 , A61K47/549 , C12N15/113 , C12N2310/14 , C12N2310/351
摘要： A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.
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公开(公告)号：US20210330808A1
公开(公告)日：2021-10-28
申请号：US17284562
申请日：2019-10-11
发明人： Jingjing Sun , Song Li
IPC分类号： A61K47/69 , A61K9/107 , A61K47/54 , A61K47/58 , A61K47/60 , A61K31/7068 , A61K31/337 , A61K31/436 , A61K38/13 , A61K31/366 , A61K31/12 , A61K31/405 , A61K31/551 , A61K31/138 , A61K31/404 , A61K31/506
摘要： A polymer includes a hydrophobic polymer backbone, a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one group including a plurality of hydroxyl groups, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and comprising at least one hydrophilic polymer.
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公开(公告)号：US20210236645A1
公开(公告)日：2021-08-05
申请号：US17049152
申请日：2019-04-20
发明人： Song Li , Jingjing Sun , Yichao Chen , Yixian Huang , Yanhua Liu , Binfeng Lu
IPC分类号： A61K47/58 , A61K47/54 , C12N15/113 , A61K9/107 , A61K31/65
摘要： A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.
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公开(公告)号：US20180214563A1
公开(公告)日：2018-08-02
申请号：US15748469
申请日：2016-07-28
发明人： Song Li , Yichao Chen , Yixian Huang
CPC分类号： A61K47/60 , A61K31/337 , A61K31/4188 , A61K31/704 , A61K45/06 , A61K47/6907 , A61K2300/00
摘要： A formulation includes a carrier agent formed by conjugating an immunotherapy agent with a hydrophilic compound. The carrier agent further includes an interactive domain comprising at least one interactive moiety which interacts with a therapeutic agent.
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公开(公告)号：US20160128938A9
公开(公告)日：2016-05-12
申请号：US14651840
申请日：2013-12-12
发明人： Xiang Gao , Song Li , Peter Wipf , Michael Wayne Epperly , Joel S. Greenberger
IPC分类号： A61K9/107 , A61K31/337 , A61K31/704 , A61K31/45
CPC分类号： A61K9/1075 , A61K9/1271 , A61K31/337 , A61K31/45 , A61K31/704
摘要： A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by conjugating at least one compound interactive domain comprising the at least one group that interacts with the compound with at least one hydrophilic domain, and combining the compound and the carrier agent to create the formulation. Creating the carrier agent may further include conjugating the at least one compound interactive domain with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.
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公开(公告)号：US10172795B2
公开(公告)日：2019-01-08
申请号：US14651840
申请日：2013-12-12
发明人： Xiang Gao , Song Li , Peter Wipf , Michael Wayne Epperly , Joel S. Greenberger
IPC分类号： A61K31/45 , A61K9/107 , A61K9/127 , A61K31/337 , A61K31/704
摘要： A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by conjugating at least one compound interactive domain comprising the at least one group that interacts with the compound with at least one hydrophilic domain, and combining the compound and the carrier agent to create the formulation. Creating the carrier agent may further include conjugating the at least one compound interactive domain with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.
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公开(公告)号：US20240131170A1
公开(公告)日：2024-04-25
申请号：US18540254
申请日：2023-12-14
发明人： Song Li , Jingjing Sun , Yichao Chen , Yixian Huang , Yanhua Liu , Binfeng Lu
IPC分类号： A61K47/58 , A61K9/107 , A61K31/65 , A61K47/54 , C12N15/113
CPC分类号： A61K47/58 , A61K9/1075 , A61K31/65 , A61K47/549 , C12N15/113 , C12N2310/14 , C12N2310/351
摘要： A formulation includes a plurality of polymers including a hydrophobic polymer backbone (for example, formed via radical polymerization), a first plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one cationic group, and a second plurality of pendant groups attached to the hydrophobic polymer backbone and including at least one hydrophilic polymer, a first therapeutic compound, and a second therapeutic compound, wherein the second therapeutic compound is different from the first therapeutic compound and includes a nucleic acid.
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公开(公告)号：US10376591B2
公开(公告)日：2019-08-13
申请号：US15703110
申请日：2017-09-13
发明人： Song Li , Yixian Huang , Xiaolan Zhang , Xiang Gao
IPC分类号： A61K47/60 , A61K31/337 , A61K31/235 , A61K31/704 , A61K9/00 , A61K9/107 , C08G65/331 , C08G65/333 , C08G65/334
摘要： A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic compound via a linkage which is labile in vivo, and a biologically active compound associated with the carrier agent.
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公开(公告)号：US20190038556A1
公开(公告)日：2019-02-07
申请号：US16154881
申请日：2018-10-09
发明人： Xiang Gao , Song Li , Peter Wipf , Michael Wayne Epperly , Joel S. Greenberger
IPC分类号： A61K9/107 , A61K31/337 , A61K31/45 , A61K31/704 , A61K9/127
摘要： A method of creating a formulation for a compound includes determining a compound interactive agent comprising at least one group that interacts with the compound, creating a carrier agent by conjugating at least one compound interactive domain comprising the at least one group that interacts with the compound with at least one hydrophilic domain, and combining the compound and the carrier agent to create the formulation. Creating the carrier agent may further include conjugating the at least one compound interactive domain with at least one hydrophobic domain so that the at least one compound interactive domain is positioned between the at least one hydrophilic domain and the at least one hydrophobic domain.
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