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公开(公告)号:US11918727B2
公开(公告)日:2024-03-05
申请号:US17328049
申请日:2021-05-24
申请人: University of Pittsburgh—Of the Commonwealth System of Higher Education , Carnegie Mellon University , Mississippi State University
发明人: Shalv Madhani , Brian Joseph Frankowski , William J. Federspiel , Gregory Burgreen , James F. Antaki
IPC分类号: A61M1/36 , A61M1/16 , A61M60/113 , A61M60/232 , A61M60/38 , A61M60/419 , A61M60/422 , A61M60/82 , A61M60/824 , A61M60/825
CPC分类号: A61M1/3667 , A61M1/1625 , A61M1/1698 , A61M1/3666 , A61M60/113 , A61M60/232 , A61M60/38 , A61M60/419 , A61M60/422 , A61M60/82 , A61M60/824 , A61M60/825 , A61M2205/7536
摘要: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment. The system further includes a fiber bundle with a plurality of hollow gas permeable fibers extending generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet.
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公开(公告)号:US20210283324A1
公开(公告)日:2021-09-16
申请号:US17328049
申请日:2021-05-24
申请人: University of Pittsburgh- Of the Commonwealth System of Higher Education , Carnegie Mellon University , Mississippi State University
发明人: Shalv Madhani , Brian Joseph Frankowski , William J. Federspiel , Gregory Burgreen , James F. Antaki
IPC分类号: A61M1/36 , A61M1/16 , A61M60/82 , A61M60/113 , A61M60/419 , A61M60/818 , A61M60/824
摘要: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.
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公开(公告)号:US20180353673A9
公开(公告)日:2018-12-13
申请号:US15738406
申请日:2016-06-23
申请人: University of Pittsburgh - Of the Commonwealth System of Higher Education , Carnegie Mellon University , Mississippi State University
发明人: Shalv Madhani , Brian Joseph Frankowski , William J. Federspiel , Gregory Burgreen , James F. Antaki
CPC分类号: A61M1/3667 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1036 , A61M1/1625 , A61M1/1698 , A61M1/3666 , A61M2205/7536
摘要: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.
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公开(公告)号:US20240165313A1
公开(公告)日:2024-05-23
申请号:US18429963
申请日:2024-02-01
申请人: University of Pittsburgh - Of the Commonwealth System of Higher Education , Carnegie Mellon University , Mississippi State University
发明人: Shalv Madhani , Brian Joseph Frankowski , William J. Federspiel , Gregory Burgreen , James F. Antaki
IPC分类号: A61M1/36 , A61M1/16 , A61M60/113 , A61M60/232 , A61M60/38 , A61M60/419 , A61M60/422 , A61M60/82 , A61M60/824 , A61M60/825
CPC分类号: A61M1/3667 , A61M1/1625 , A61M1/1698 , A61M1/3666 , A61M60/113 , A61M60/232 , A61M60/38 , A61M60/419 , A61M60/422 , A61M60/82 , A61M60/824 , A61M60/825 , A61M2205/7536
摘要: An extracorporeal system for lung assist includes a housing having a blood flow inlet in fluid connection with a pressurizing stator compartment within the housing. A fiber bundle compartment within the housing is above and in fluid connection with the pressurizing stator compartment via a flow channel formed within the housing and extending from the pressurizing stator compartment to an inlet manifold of the fiber bundle compartment. A blood flow outlet in is fluid connection with an outlet man fold of the fiber bundle compartment. The blood flow inlet extends through the housing parallel to a plane of rotation of an impeller in the pressurizing stator compartment. The blood flow inlet turns to deliver blood into a central portion of the impeller. A has inlet is in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers of a cylindrical fiber bundle positioned within the fiber bundle compartment. A gas outlet is in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.
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公开(公告)号:US11045597B2
公开(公告)日:2021-06-29
申请号:US15738406
申请日:2016-06-23
申请人: University of Pittsburgh—Of the Commonwealth System of Higher Education , Carnegie Mellon University , Mississippi State University
发明人: Shalv Madhani , Brian Joseph Frankowski , William J. Federspiel , Gregory Burgreen , James F. Antaki
IPC分类号: A61M1/36 , A61M1/16 , A61M60/113 , A61M60/205 , A61M60/82 , A61M60/419 , A61M60/818 , A61M60/824
摘要: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment. The system further includes a fiber bundle within the fiber bundle compartment. A plurality of hollow gas permeable fibers of the fiber bundle extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet.
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公开(公告)号:US20180185567A1
公开(公告)日:2018-07-05
申请号:US15738406
申请日:2016-06-23
申请人: University of Pittsburgh - Of the Commonwealth System of Higher Education , Carnegie Mellon University , Mississippi State University
发明人: Shalv Madhani , Brian Joseph Frankowski , William J. Federspiel , Gregory Burgreen , James F. Antaki
CPC分类号: A61M1/3667 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1036 , A61M1/1625 , A61M1/1698 , A61M1/3666 , A61M2205/7536
摘要: An extracorporeal system for lung assist includes a housing which includes a blood flow inlet in fluid connection with a pressurizing stator compartment, a fiber bundle compartment in fluid connection with the pressurizing stator compartment via a flow channel within the housing, and a blood flow outlet in fluid connection with the fiber bundle compartment. An impeller is rotatably positioned within the pressurizing compartment for pressurizing blood entering the pressurizing stator compartment from the blood flow inlet. The system further includes a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is adapted to permit diffusion of gas between blood and an interior of the hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. The plurality of hollow gas permeable fibers extend generally perpendicular to the direction of bulk flow of blood through the fiber bundle compartment from the flow channel to the blood flow outlet. The system further includes a gas inlet in fluid connection with the housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers and a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers.
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公开(公告)号:US20220080095A2
公开(公告)日:2022-03-17
申请号:US16961440
申请日:2019-01-15
申请人: University of Pittsburgh - Of the Commonwealth System of Higher Education , Mississippi State University
发明人: William J. Federspiel , Shalv Madhani , Ryan A. Orizondo , Peter Drew Wearden , Brian Joseph Frankowski , Alexandra May , Gregory Burgreen
摘要: A system for lung assist includes a plurality of fiber bundle sections. Each of the fiber bundle sections includes a fiber bundle housing defining a fiber bundle compartment therein and a fiber bundle positioned within the fiber bundle compartment. The fiber bundle includes a plurality of hollow gas permeable fibers configured to permit diffusion of gas between blood and an interior of the plurality of hollow gas permeable fibers. The plurality of hollow gas permeable fibers is positioned such that blood flows around the plurality of hollow gas permeable fibers when flowing through the fiber bundle compartment. Each fiber bundle is different in at least one property from each other fiber bundle. The fiber bundle housing further includes a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, and a blood outlet in fluid connection with a first end of the fiber bundle. The fiber bundle housing also includes a first interface. The system further includes a base section including a housing including a pressurizing compartment, a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit in fluid connection with the pressurizing compartment at a first end thereof via which pressurized fluid exits the pressurizing compartment. The base further includes a second interface adapted to form a releasable, sealing connection with the first interface of one of the plurality of fiber bundle sections. A second end of the conduit is placed in fluid connection with a second end of the fiber bundle when the fiber bundle section is connected to the base section via the first interface and the second interface.
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公开(公告)号:US20210077706A1
公开(公告)日:2021-03-18
申请号:US16961440
申请日:2019-01-15
申请人: University of Pittsburgh - Of theCommonwealth System of Higher Education , Mississippi State University
发明人: William J. Federspiel , Shalv Madhani , Ryan A. Orizondo , Peter Drew Wearden , Brian Joseph Frankowski , Alexandra May , Gregory Burgreen
摘要: A system for lung assist includes a plurality of fiber bundle sections which includes a fiber bundle housing defining a fiber bundle compartment with a fiber bundle positioned within. The fiber bundle includes a plurality of hollow gas permeable fibers. The fiber bundle housing further includes a gas inlet in fluid connection with the fiber bundle housing and in fluid connection with inlets of the plurality of hollow gas permeable fibers, a gas outlet in fluid connection with the housing and in fluid connection with outlets of the plurality of hollow gas permeable fibers, and a blood outlet in fluid connection with a first end of the fiber bundle. The system further includes a base section including a housing including a pressurizing compartment, a pressurizing mechanism within the pressurizing compartment, a blood inlet in fluid connection with the pressurizing compartment and a conduit.
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