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公开(公告)号：US20180120312A1
公开(公告)日：2018-05-03
申请号：US15572190
申请日：2016-05-03
Applicant: University of Southampton
Inventor： Collin Lawrence Sones , Robert William Eason
IPC: G01N33/558 , B01L3/00 , C12Q1/48 , G01N21/77 , G01N33/52 , G01N33/543
CPC classification number: G01N33/558 , B01L3/502707 , B01L2300/126 , C12Q1/48 , G01N21/77 , G01N33/523 , G01N33/526 , G01N33/54386
Abstract: A method of making a fluid flow device comprises providing a substrate of porous material, depositing a radiation-sensitive substance onto the substrate in a pattern defining one or more regions intended to receive and contain fluid during use of the device or occupying an area within such a region, such that the radiation-sensitive substance extends at least partly through the thickness of the substrate below the pattern, and exposing radiation onto the substrate thereby delivering energy to the radiation-sensitive substance in at least part of the pattern to change the radiation-sensitive substance from a first state to a second state through at least part of the thickness of the substrate. One of the first state and the second state may be less permeable than the other.
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公开(公告)号：US10682643B2
公开(公告)日：2020-06-16
申请号：US15311041
申请日：2015-05-07
Applicant: University of Southampton
Inventor： Collin Lawrence Sones , Robert William Eason , Ioannis Nikolaos Katis
Abstract: A method of making a fluid flow device comprises: providing a substrate of porous material (2) impregnated with a light-sensitive substance (5) in a first state and which is configured to change from the first state to a second state when exposed to light (3), the second state being a solid state that is resistant to a solvent and the first being removable with the solvent; the substrate having a fluid flow channel (7) defined therein, the channel having a depth; exposing a beam of light (3) onto an area of the substrate surface within the fluid flow channel to deliver energy to a volume of the substrate below the area to change the light-sensitive substance to the second state; during exposure, creating a partial barrier to flow of fluid along the channel by controlling the amount of energy delivered to the volume below at least part of the area to change the light-sensitive substance to the second state in a volume of the substrate within the fluid flow channel that has a depth less than the depth of the fluid flow channel; and developing the substrate in the solvent to leave the light-sensitive substance which is in the solid state and remove the light-sensitive substance which is in the other state. The device may be a medical diagnostic device, and the substrate may be a paper substrate or may be a nitrocellulose substrate.
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公开(公告)号：US10794905B2
公开(公告)日：2020-10-06
申请号：US15572190
申请日：2016-05-03
Applicant: University of Southampton
Inventor： Collin Lawrence Sones , Robert William Eason
IPC: G01N33/558 , B01L3/00 , C12Q1/48 , G01N21/77 , G01N33/52 , G01N33/543
Abstract: A method of making a fluid flow device comprises providing a substrate of porous material, depositing a radiation-sensitive substance onto the substrate in a pattern defining one or more regions intended to receive and contain fluid during use of the device or occupying an area within such a region, such that the radiation-sensitive substance extends at least partly through the thickness of the substrate below the pattern, and exposing radiation onto the substrate thereby delivering energy to the radiation-sensitive substance in at least part of the pattern to change the radiation-sensitive substance from a first state to a second state through at least part of the thickness of the substrate. One of the first state and the second state may be less permeable than the other.
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