公开(公告)号：US12263193B2

公开(公告)日：2025-04-01

申请号：US17284759

申请日：2019-10-14

Applicant: University of Washington

Inventor： Paul Yager ,  Jonathan Himmelfarb ,  Mari-Karoliina Henriikka Winkler ,  Erin Heiniger ,  Sujatha Kumar ,  David Stahl ,  Bruce Godfrey

IPC: A61K35/74 ,  A61K9/16

Abstract: Compositions and method for reducing the concentration of uremic toxins in the body of a patient suffering from some degree of kidney failure are disclosed. The methods can be used to delay the need for conventional dialysis treatment or as an adjunct therapy to reduce the frequency of dialysis sessions, and in some instances, as an alternative to such dialysis sessions.

公开(公告)号：US20220000938A1

公开(公告)日：2022-01-06

申请号：US17284759

申请日：2019-10-14

Applicant: University of Washington

Inventor： Paul Yager ,  Jonathan Himmelfarb ,  Mari-Karoliina Henriikka Winkler ,  Erin Heiniger ,  Sujatha Kumar ,  David Stahl ,  Bruce Godfrey

IPC: A61K35/74 ,  A61K9/16

Abstract: Compositions and method for reducing the concentration of uremic toxins in the body of a patient suffering from some degree of kidney failure are disclosed. The methods can be used to delay the need for conventional dialysis treatment or as an adjunct therapy to reduce the frequency of dialysis sessions, and in some instances, as an alternative to such dialysis sessions.

公开(公告)号：US20180119202A1

公开(公告)日：2018-05-03

申请号：US15801223

申请日：2017-11-01

Applicant: University of Washington

Inventor： Paul Yager ,  Joshua Bishop ,  Erin Heiniger

IPC: C12Q1/68 ,  G01N33/543

CPC classification number: C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6818 ,  C12Q1/6844 ,  G01N33/54306 ,  C12Q2565/531 ,  C12Q2563/179

Abstract: The present technology is related to methods and compositions for detecting, and optionally quantifying, one or more analytes of a sample using nucleic acids. In some embodiments, the methods include generating a complex of a plurality of peptides, an analyte, a first nucleic acid, and a second nucleic acid, each nucleic acid conjugated to a binder peptide. In addition, an immobilizer peptide can be immobilized to a substrate. If the binder peptides are bound to the analyte, the method further includes hybridizing a segment of the first nucleic acid to a segment of the second nucleic acid and amplifying the hybridized nucleic acids to generate a plurality of amplicons. Moreover, the generated amplicons indicate that one or more analytes has been detected. A number of generated amplicons can be analyzed to quantify one or more of the bound analytes.