公开(公告)号：US12263193B2

公开(公告)日：2025-04-01

申请号：US17284759

申请日：2019-10-14

Applicant: University of Washington

Inventor： Paul Yager ,  Jonathan Himmelfarb ,  Mari-Karoliina Henriikka Winkler ,  Erin Heiniger ,  Sujatha Kumar ,  David Stahl ,  Bruce Godfrey

IPC: A61K35/74 ,  A61K9/16

Abstract: Compositions and method for reducing the concentration of uremic toxins in the body of a patient suffering from some degree of kidney failure are disclosed. The methods can be used to delay the need for conventional dialysis treatment or as an adjunct therapy to reduce the frequency of dialysis sessions, and in some instances, as an alternative to such dialysis sessions.

公开(公告)号：US11098346B2

公开(公告)日：2021-08-24

申请号：US16059919

申请日：2018-08-09

Applicant: University of Washington

Inventor： Joshua Bishop ,  Joshua Buser ,  Samantha Byrnes ,  Shivani Dharmaraja ,  Elain S. Fu ,  Jared Houghtaling ,  Peter C. Kauffman ,  Sujatha Kumar ,  Lisa Lafleur ,  Tinny Liang ,  Barry Lutz ,  Bhushan Toley ,  Maxwell Wheeler ,  Paul Yager ,  Xiaohong Zhang

IPC: B01L7/00 ,  C12Q1/6844 ,  B01L3/00

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

公开(公告)号：US20220395838A1

公开(公告)日：2022-12-15

申请号：US17838807

申请日：2022-06-13

Applicant: University of Washington

Inventor： Paul Yager ,  Steven Bennett ,  Erin K. Heiniger ,  Sujatha Kumar ,  Kamal Girish Shah

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/6806

Abstract: Fluidic devices, systems, and methods for analyzing an analyte are described. In an embodiment, the fluidic devices include a housing defining a lysis chamber shaped to receive a biological sample; a lysis buffer storage chamber disposed within the housing and carrying a lysis buffer configured to lyse cells of the biological sample; a cap configured to cooperatively couple to the housing; a compressor configured to compress the lysis buffer storage chamber and expel the lysis buffer from the lysis buffer storage chamber and into the lysis chamber when the cap is uncoupled from the housing; and a porous membrane in selective fluidic communication with the lysis chamber.

公开(公告)号：US20190134637A1

公开(公告)日：2019-05-09

申请号：US16059919

申请日：2018-08-09

Applicant: University of Washington

Inventor： Joshua Bishop ,  Joshua Buser ,  Samantha Byrnes ,  Shivani Dharmaraja ,  Elain S. Fu ,  Jared Houghtaling ,  Peter C. Kauffman ,  Sujatha Kumar ,  Lisa Lafleur ,  Tinny Liang ,  Barry Lutz ,  Bhushan Toley ,  Maxwell Wheeler ,  Paul Yager ,  Xiaohong Zhang

IPC: B01L7/00 ,  B01L3/00

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

公开(公告)号：US20220000938A1

公开(公告)日：2022-01-06

申请号：US17284759

申请日：2019-10-14

Applicant: University of Washington

Inventor： Paul Yager ,  Jonathan Himmelfarb ,  Mari-Karoliina Henriikka Winkler ,  Erin Heiniger ,  Sujatha Kumar ,  David Stahl ,  Bruce Godfrey

IPC: A61K35/74 ,  A61K9/16

Abstract: Compositions and method for reducing the concentration of uremic toxins in the body of a patient suffering from some degree of kidney failure are disclosed. The methods can be used to delay the need for conventional dialysis treatment or as an adjunct therapy to reduce the frequency of dialysis sessions, and in some instances, as an alternative to such dialysis sessions.

公开(公告)号：US20170131211A1

公开(公告)日：2017-05-11

申请号：US15348926

申请日：2016-11-10

Applicant: University of Washington

Inventor： Paul Yager ,  Joshua Bishop ,  Joshua Buser ,  Louise Lyth Hansen ,  Erin K. Heiniger ,  Enos Kline ,  Sujatha Kumar

IPC: G01N21/64 ,  C12Q1/68

CPC classification number: G01N21/6486 ,  B01L3/00 ,  B01L3/5023 ,  B01L2200/026 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0832 ,  B01L2300/0864 ,  B01L2300/1827 ,  B01L2400/0406 ,  C12Q1/6816 ,  C12Q1/6844 ,  G01N1/286 ,  G01N21/645 ,  G01N2001/4088

Abstract: The present technology relates generally to systems for disrupting biological samples and associated devices and methods. In some embodiments, the system includes a vessel configured to receive a biological sample and a cap assembly that includes a porous membrane having a receiving region and a detection region. When the cap assembly is detachably coupled to an open end portion of the vessel, the system can be moved between a first orientation and a second orientation. When the system is in the first orientation, the biological sample is not in fluid communication with the receiving region. When the vessel contains is in the second orientation, the biological sample is in fluid communication with the receiving region and wicks through the porous membrane to the detection region.

公开(公告)号：US20230201824A1

公开(公告)日：2023-06-29

申请号：US18000163

申请日：2021-08-13

Applicant: University of Washington

Inventor： Paul Yager ,  Sujatha Kumar

IPC: B01L3/00 ,  C12Q1/6844

CPC classification number: B01L3/502715 ,  B01L3/52 ,  C12Q1/6844 ,  B01L2300/069

Abstract: Fluidic device and methods of preparing a fibrous pad comprising dried reagents deposited thereon are described. In an embodiment, the fluidic devices comprise a fibrous pad; and a lyophilized reagent depot configured to support nucleic amplification of a target nucleic acid molecule to produce amplicons when dissolved, wherein the lyophilized reagent depot is disposed on the fibrous pad, the lyophilized reagent depot comprising: a nucleic acid amplification enzyme configured to perform a nucleic acid amplification reaction producing amplicons; and a lyophilization agent.

公开(公告)号：US20220371006A1

公开(公告)日：2022-11-24

申请号：US17761138

申请日：2020-10-01

Applicant: University of Washington

Inventor： Paul Yager ,  Steven Bennett ,  Sujatha Kumar ,  Kamal Girish Shah ,  Erin K. Heiniger

IPC: B01L3/00 ,  G01N1/14

Abstract: An apparatus, system, and method for filtering and assaying a fluid sample are described. In an embodiment, the apparatus includes a filtration unit comprising: a filter bracket shaped to removably couple with a fluid sample cup and a vacuum container; and a filter housing cooperatively couplable to the filter bracket and comprising a filter configured to filter fluid passing through the filter bracket; and an assay device shaped to cooperatively couple with the filter housing and comprising a porous matrix positioned to be in fluidic communication with the filter when the filter housing is cooperatively coupled with the assay device.

公开(公告)号：US20150361487A1

公开(公告)日：2015-12-17

申请号：US14761604

申请日：2014-01-22

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

Inventor： Joshua Bishop ,  Joshua Buser ,  Samantha Byrnes ,  Shivani Dharmaraja ,  Elain S. Fu ,  Jared Houghtaling ,  Peter C. Kauffman ,  Sujatha Kumar ,  Lisa Lafleur ,  Tinny Liang ,  Barry Lutz ,  Bhushan Toley ,  Maxwell Wheeler ,  Paul Yager ,  Xiaohong Zhang

IPC: C12Q1/68 ,  B01L7/00 ,  B01L3/00

CPC classification number: B01L7/00 ,  B01L3/5023 ,  B01L7/52 ,  B01L2300/0672 ,  B01L2300/0825 ,  B01L2300/0867 ,  B01L2300/1827 ,  B01L2300/1855 ,  B01L2300/1877 ,  B01L2400/0406 ,  B01L2400/0672 ,  B01L2400/0683 ,  Y10T436/2575

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a porous receiving element having an input region and a receiving region, a first fluid source and a second fluid source positioned within the input region of the receiving element; wherein the first fluid source is positioned between the second fluid source and the receiving region, and wherein, when both the first and second fluid sources are in fluid connection with the input region, the device is configured to sequentially deliver the first fluid and the second fluid to the receiving region without leakage.

Abstract translation: 本技术涉及用于执行化学过程和相关系统和方法的基于毛细管的装置。 在一个实施例中，例如，设备可以包括具有输入区域和接收区域的多孔接收元件，位于接收元件的输入区域内的第一流体源和第二流体源; 其中所述第一流体源位于所述第二流体源和所述接收区域之间，并且其中当所述第一流体源和所述第二流体源都与所述输入区域流体连接时，所述装置构造成顺序地输送所述第一流体和所述第二流体源 流体到接收区域而没有泄漏。