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    DEVICE AND METHOD FOR DETECTION OF PATHOGENS
    2.
    发明申请
    DEVICE AND METHOD FOR DETECTION OF PATHOGENS 有权

    公开(公告)号：US20220395838A1

    公开(公告)日：2022-12-15

    申请号：US17838807

    申请日：2022-06-13

    Applicant: University of Washington

    Inventor： Paul Yager ,  Steven Bennett ,  Erin K. Heiniger ,  Sujatha Kumar ,  Kamal Girish Shah

    IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/6806

    Abstract: Fluidic devices, systems, and methods for analyzing an analyte are described. In an embodiment, the fluidic devices include a housing defining a lysis chamber shaped to receive a biological sample; a lysis buffer storage chamber disposed within the housing and carrying a lysis buffer configured to lyse cells of the biological sample; a cap configured to cooperatively couple to the housing; a compressor configured to compress the lysis buffer storage chamber and expel the lysis buffer from the lysis buffer storage chamber and into the lysis chamber when the cap is uncoupled from the housing; and a porous membrane in selective fluidic communication with the lysis chamber.

    Temperature-actuated valve, fluidic device, and related methods of use
    3.
    发明授权
    Temperature-actuated valve, fluidic device, and related methods of use 有权

    公开(公告)号：US10935149B2

    公开(公告)日：2021-03-02

    申请号：US16354987

    申请日：2019-03-15

    Applicant: University of Washington

    Inventor： Paul Yager ,  Joshua Bishop ,  Michael Purfield

    IPC: F16K17/38 ,  F16K99/00 ,  B01L3/00

    Abstract: Temperature-actuated valves, devices including temperature-actuated valves, and related methods are described. In an embodiment, the temperature-actuated valve includes a heat-shrink film defining a perforation extending at least partially in a first direction. In an embodiment, the temperature-actuated valve is configured to open when a portion of the heat-shrink film including the perforation is heated above a threshold temperature to contract the heat-shrink film along a second direction perpendicular to the first direction to define an aperture, in an open configuration, providing a fluid a path through the heat-shrink film. In an embodiment, the temperature-actuated valve includes a leakage-mitigation feature configured to limit fluid flow through the perforation when the valve is in a closed configuration.

    TEMPERATURE-ACTUATED VALVE, FLUIDIC DEVICE, AND RELATED METHODS OF USE
    4.
    发明申请
    TEMPERATURE-ACTUATED VALVE, FLUIDIC DEVICE, AND RELATED METHODS OF USE 审中-公开

    公开(公告)号：US20190285187A1

    公开(公告)日：2019-09-19

    申请号：US16354987

    申请日：2019-03-15

    Applicant: University of Washington

    Inventor： Paul Yager ,  Joshua Bishop ,  Michael Purfield

    IPC: F16K17/38 ,  F16K99/00

    Abstract: Temperature-actuated valves, devices including temperature-actuated valves, and related methods are described. In an embodiment, the temperature-actuated valve includes a heat-shrink film defining a perforation extending at least partially in a first direction. In an embodiment, the temperature-actuated valve is configured to open when a portion of the heat-shrink film including the perforation is heated above a threshold temperature to contract the heat-shrink film along a second direction perpendicular to the first direction to define an aperture, in an open configuration, providing a fluid a path through the heat-shrink film. In an embodiment, the temperature-actuated valve includes a leakage-mitigation feature configured to limit fluid flow through the perforation when the valve is in a closed configuration.

    PRESSURE-BASED CONTROL OF FLUID VOLUMES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS
    6.
    发明申请
    PRESSURE-BASED CONTROL OF FLUID VOLUMES AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS 审中-公开
    流体压力和相关设备的压力控制，系统和方法

    公开(公告)号：US20160310942A1

    公开(公告)日：2016-10-27

    申请号：US15135461

    申请日：2016-04-21

    Applicant: University of Washington

    Inventor： Paul Yager ,  Joshua Buser ,  Samantha Byrnes ,  Erin K. Heiniger ,  Peter C. Kauffman ,  Paula Ladd

    IPC: B01L3/00 ,  C12Q1/68

    CPC classification number: B01L3/50273 ,  B01L2300/069 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0683 ,  C12Q1/6844

    Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a first porous element having a first pore size and configured to receive a fluid at its proximal portion, and a second porous element having a second pore size greater than the first pore size and configured to receive a fluid at its proximal portion. The first porous element can be positioned across the second porous element such that an overlapping region exists between the porous elements where the porous elements are in fluid communication. Before delivery of the fluid to the second porous element, the fluid pressure at the overlapping region is greater than the capillary pressure of the second porous element such that a fluid delivered to the first porous element wicks through its overlapping portion without wetting the second porous element.

    Abstract translation: 本技术涉及用于执行化学过程和相关系统和方法的基于毛细管的装置。 在一个实施例中，例如，装置可以包括具有第一孔径并被配置为在其近端部分处接收流体的第一多孔元件和具有大于第一孔径的第二孔径的第二多孔元件，并且被配置为 在其近端部分接收流体。 第一多孔元件可以跨越第二多孔元件定位，使得在多孔元件处于流体连通的多孔元件之间存在重叠区域。 在将流体输送到第二多孔元件之前，重叠区域处的流体压力大于第二多孔元件的毛细管压力，使得输送到第一多孔元件的流体通过其重叠部分吸入而不润湿第二多孔元件 。

    LONG-TERM DRY STORAGE OF ENZYME-BASED REAGENTS IN A POROUS MATRIX
    7.
    发明公开
    LONG-TERM DRY STORAGE OF ENZYME-BASED REAGENTS IN A POROUS MATRIX 审中-公开

    公开(公告)号：US20230201824A1

    公开(公告)日：2023-06-29

    申请号：US18000163

    申请日：2021-08-13

    Applicant: University of Washington

    Inventor： Paul Yager ,  Sujatha Kumar

    IPC: B01L3/00 ,  C12Q1/6844

    CPC classification number: B01L3/502715 ,  B01L3/52 ,  C12Q1/6844 ,  B01L2300/069

    Abstract: Fluidic device and methods of preparing a fibrous pad comprising dried reagents deposited thereon are described. In an embodiment, the fluidic devices comprise a fibrous pad; and a lyophilized reagent depot configured to support nucleic amplification of a target nucleic acid molecule to produce amplicons when dissolved, wherein the lyophilized reagent depot is disposed on the fibrous pad, the lyophilized reagent depot comprising: a nucleic acid amplification enzyme configured to perform a nucleic acid amplification reaction producing amplicons; and a lyophilization agent.

    PATHOGEN FILTRATION APPARATUS, SYSTEM, AND METHOD
    8.
    发明申请
    PATHOGEN FILTRATION APPARATUS, SYSTEM, AND METHOD 有权

    公开(公告)号：US20220371006A1

    公开(公告)日：2022-11-24

    申请号：US17761138

    申请日：2020-10-01

    Applicant: University of Washington

    Inventor： Paul Yager ,  Steven Bennett ,  Sujatha Kumar ,  Kamal Girish Shah ,  Erin K. Heiniger

    IPC: B01L3/00 ,  G01N1/14

    Abstract: An apparatus, system, and method for filtering and assaying a fluid sample are described. In an embodiment, the apparatus includes a filtration unit comprising: a filter bracket shaped to removably couple with a fluid sample cup and a vacuum container; and a filter housing cooperatively couplable to the filter bracket and comprising a filter configured to filter fluid passing through the filter bracket; and an assay device shaped to cooperatively couple with the filter housing and comprising a porous matrix positioned to be in fluidic communication with the filter when the filter housing is cooperatively coupled with the assay device.

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