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公开(公告)号：US20160354480A1
公开(公告)日：2016-12-08
申请号：US15111835
申请日：2015-01-19
IPC分类号： A61K47/48
摘要： The present invention relates to activated neurotensin, pharmaceutical compositions comprising the same, and the uses thereof. The compounds and compositions of the invention may be used e.g., to reduce body temperature, attenuate or halt seizures, reduce excitotoxicity, promote neuroprotection, reduce neuroinflammation and aberrant axonal sprouting or reduce pain.
摘要翻译： 本发明涉及活化的神经丝氨酸，包含其的药物组合物及其用途。 本发明的化合物和组合物可用于例如降低体温，减弱或停止癫痫发作，降低兴奋性毒性，促进神经保护作用，减少神经炎症和异常轴突发芽或减轻疼痛。
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公开(公告)号：US20190351079A1
公开(公告)日：2019-11-21
申请号：US16479234
申请日：2018-01-30
发明人： CÉDRIC MALICET , PASCALINE LECORCHE , JONATHAN NOWAK , MARION DAVID , JAMAL TEMSAMANI , MICHEL KHRESTCHATISKY
摘要： The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.
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公开(公告)号：US20240100204A1
公开(公告)日：2024-03-28
申请号：US18360859
申请日：2023-07-28
发明人： CÉDRIC MALICET , PASCALINE LECORCHE , JONATHAN NOWAK , MARION DAVID , JAMAL TEMSAMANI , MICHEL KHRESTCHATISKY
CPC分类号： A61K51/088 , A61K51/048 , C07K7/06 , G01N33/57438 , G01N33/60 , G01N33/92 , A61K2121/00 , A61K2123/00
摘要： The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.
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公开(公告)号：US20230414780A1
公开(公告)日：2023-12-28
申请号：US18339781
申请日：2023-06-22
发明人： ROMY COHEN , MARION DAVID , GUILLAUME JACQUOT , JAMAL TEMSAMANI , PASCALINE LECORCHE , MICHEL KHRESTCHATISKY
CPC分类号： A61K47/6849 , A61K47/6807 , A61K47/68 , A61K47/6811 , A61P35/00
摘要： The invention relates to Variable Domain of Camelid Heavy Chain-only (VHH) molecules which bind TfR, conjugate compounds comprising such VHH molecules, and the uses thereof e.g., to transport molecules of pharmaceutical or diagnostic interest into cells and in organs, in pathological conditions including cancer.
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