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公开(公告)号：US12152317B2
公开(公告)日：2024-11-26
申请号：US17421412
申请日：2020-01-08
Inventor： Romy Cohen , Marion David , Michel Khrestchatisky
Abstract: The invention relates to Variable Domain of Camelid Heavy Chain-only (VHH) molecules which bind TfR and the uses thereof e.g., to transport molecules of pharmaceutical or diagnostic interest into cells and in organs, in pathological conditions including cancer.
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公开(公告)号：US20220090050A1
公开(公告)日：2022-03-24
申请号：US17421412
申请日：2020-01-08
Inventor： ROMY COHEN , MARION DAVID , MICHEL KHRESTCHATISKY
Abstract: The invention relates to Variable Domain of Camelid Heavy Chain-only (VHH) molecules which bind TfR and the uses thereof e.g., to transport molecules of pharmaceutical or diagnostic interest into cells and in organs, in pathological conditions including cancer.
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公开(公告)号：US20160354480A1
公开(公告)日：2016-12-08
申请号：US15111835
申请日：2015-01-19
Applicant: VECT-HORUS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventor： GUILLAUME JACQUOT , PASCALINE LECORCHE , MICHEL KHRESTCHATISKY
IPC: A61K47/48
Abstract: The present invention relates to activated neurotensin, pharmaceutical compositions comprising the same, and the uses thereof. The compounds and compositions of the invention may be used e.g., to reduce body temperature, attenuate or halt seizures, reduce excitotoxicity, promote neuroprotection, reduce neuroinflammation and aberrant axonal sprouting or reduce pain.
Abstract translation: 本发明涉及活化的神经丝氨酸，包含其的药物组合物及其用途。 本发明的化合物和组合物可用于例如降低体温，减弱或停止癫痫发作，降低兴奋性毒性，促进神经保护作用，减少神经炎症和异常轴突发芽或减轻疼痛。
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公开(公告)号：US20130108548A1
公开(公告)日：2013-05-02
申请号：US13655954
申请日：2012-10-19
Applicant: VECT-HORUS , Center National De La Recherche Scientifique , UNIVERSITE DE LA MEDITERRANEE
Inventor： PATRICK VLIEGHE , MARION DAVID , YVES MOLINO , MICHEL KHRESTCHATISKY
CPC classification number: C07K7/06 , A61K47/64 , C07K14/775 , C07K2319/33 , C07K2319/74
Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and the use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides of the invention can be used, in particular, to vectorize, generally in the form of prodrug conjugates, molecules of pharmaceutical or diagnostic interest such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes of different tissues or organs, healthy or pathologic, and in particular to enable their transport across physiological barriers of the nervous system such as the Blood brain barrier (BBB), Blood-spinal cord barrier (BSCB), or Blood-retinal barrier (BRB).
Abstract translation: 本发明涉及肽衍生物（肽和假肽）及其作为感兴趣分子载体的用途。 本发明还涉及含有与感兴趣分子结合的本发明的肽衍生物的缀合物。 本发明的肽可以特别用于通常以前药缀合物的形式，药物或诊断感兴趣的分子（例如治疗分子，成像或诊断试剂或分子探针）跨细胞膜的载体 不同的组织或器官，健康或病理，特别是使其能够跨过神经系统的生理屏障，例如血脑屏障（BBB），血液脊髓屏障（BSCB）或血液视网膜屏障（BRB ）。
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公开(公告)号：US20240100204A1
公开(公告)日：2024-03-28
申请号：US18360859
申请日：2023-07-28
Inventor： CÉDRIC MALICET , PASCALINE LECORCHE , JONATHAN NOWAK , MARION DAVID , JAMAL TEMSAMANI , MICHEL KHRESTCHATISKY
CPC classification number: A61K51/088 , A61K51/048 , C07K7/06 , G01N33/57438 , G01N33/60 , G01N33/92 , A61K2121/00 , A61K2123/00
Abstract: The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.
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Patent Agency Ranking
公开(公告)号：US20230414780A1
公开(公告)日：2023-12-28
申请号：US18339781
申请日：2023-06-22
Inventor： ROMY COHEN , MARION DAVID , GUILLAUME JACQUOT , JAMAL TEMSAMANI , PASCALINE LECORCHE , MICHEL KHRESTCHATISKY
CPC classification number: A61K47/6849 , A61K47/6807 , A61K47/68 , A61K47/6811 , A61P35/00
Abstract: The invention relates to Variable Domain of Camelid Heavy Chain-only (VHH) molecules which bind TfR, conjugate compounds comprising such VHH molecules, and the uses thereof e.g., to transport molecules of pharmaceutical or diagnostic interest into cells and in organs, in pathological conditions including cancer.
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公开(公告)号：US09821072B2
公开(公告)日：2017-11-21
申请号：US15111835
申请日：2015-01-19
Applicant: VECT-HORUS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventor： Guillaume Jacquot , Pascaline Lecorche , Michel Khrestchatisky
IPC: C07K7/08 , C07K7/06 , A61K38/10 , A61K38/08 , A61P25/08 , A61P25/00 , A61P9/00 , A61K47/48 , A61K38/00
Abstract: The present invention relates to activated neurotensin, pharmaceutical compositions comprising the same, and the uses thereof. The compounds and compositions of the invention may be used, e.g., to reduce body temperature, attenuate or halt seizures, reduce excitotoxicity, promote neuroprotection, reduce neuroinflammation and aberrant axonal sprouting or reduce pain.
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8.发明授权Peptide derivatives and use thereof as carriers for molecules in the form of conjugates 有权肽衍生物及其作为缀合物形式的分子的载体的用途公开(公告)号：US09328143B2
公开(公告)日：2016-05-03
申请号：US14277339
申请日：2014-05-14
Inventor： Michel Khrestchatisky , Marion David , Yves Molino , Patrick Vlieghe
CPC classification number: C07K7/64 , A61K38/00 , C07K4/00 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/775
Abstract: The invention relates to peptide derivatives (peptides and pseudo-peptides) and use thereof as vectors for molecules of interest. The invention also relates to conjugates containing a peptide derivative of the invention bound to a molecule of interest. The peptides and prodrug conjugates of the invention can be used to vectorize molecules of pharmaceutical or diagnostic interest, such as, for example, therapeutic molecules, imaging or diagnostic agents, or molecular probes, across cell membranes, and notably to promote their transport across the blood-brain barrier (BBB).
Abstract translation: 本发明涉及肽衍生物（肽和假肽）及其作为感兴趣分子载体的用途。 本发明还涉及含有与感兴趣分子结合的本发明的肽衍生物的缀合物。 本发明的肽和前药缀合物可以用于在药物或诊断感兴趣的分子（例如治疗分子，成像或诊断试剂或分子探针）中跨越细胞膜载体化，并且特别地促进其跨过 血脑屏障（BBB）。
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公开(公告)号：US11712486B2
公开(公告)日：2023-08-01
申请号：US16479234
申请日：2018-01-30
Inventor： Cédric Malicet , Pascaline Lecorche , Jonathan Nowak , Marion David , Jamal Temsamani , Michel Khrestchatisky
CPC classification number: A61K51/088 , A61K51/048 , C07K7/06 , G01N33/57438 , G01N33/60 , G01N33/92 , A61K2121/00 , A61K2123/00
Abstract: The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.
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公开(公告)号：US20190351079A1
公开(公告)日：2019-11-21
申请号：US16479234
申请日：2018-01-30
Inventor： CÉDRIC MALICET , PASCALINE LECORCHE , JONATHAN NOWAK , MARION DAVID , JAMAL TEMSAMANI , MICHEL KHRESTCHATISKY
Abstract: The present invention relates to a conjugated compound comprising a marker M pharmaceutically acceptable, and a peptide or pseudo-peptide P having at most 30 amino acid residues and able to bind the Low-Density Lipoprotein Receptor (LDLR) and to its use in a method of labelling and/or detecting and/or treating cancerous cells in a subject by administration of the conjugated compound to the subject an analysis of the presence and/or the amount of marker.
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