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公开(公告)号：US20230338555A1
公开(公告)日：2023-10-26
申请号：US17998141
申请日：2021-05-18
发明人： Thazha P. Prakash , Mehran Nikan , Michael Tanowitz , Chrissa A. Dwyer , Frank Rigo , Punit P. Seth
摘要： Disclosed herein are compounds that comprise an oligonucleotide, a conjugate linker, and a conjugate moiety capable of interacting with a cell surface moiety, wherein the oligonucleotide and the conjugate moiety are connected via the conjugate linker. The conjugate moiety may comprise a cell-targeting moiety and a peptide extender. In general, peptide extenders have sufficient length and/or structure to reduce or prevent interaction between the oligonucleotide and the cell-targeting moiety. Such compounds are useful to treat, prevent or ameliorate a condition or disease in an individual with limited off-target effects.
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公开(公告)号：US09809624B2
公开(公告)日：2017-11-07
申请号：US13384418
申请日：2010-07-16
申请人： Anne Gruaz , Didier Pelaprat , Jacques Barbet , Dirk Tourwe
发明人： Anne Gruaz , Didier Pelaprat , Jacques Barbet , Dirk Tourwe
CPC分类号： C07K7/083 , A61K38/00 , A61K51/08 , A61K51/085 , A61K51/088
摘要： The invention relates to a new neurotensin analogue, or a salt thereof, useful for targeting to neurotensin receptor-positive tumors, like ductal pancreatic adenocarcinoma, exocrine pancreatic cancer, invasive ductal breast cancers, colon adenocarcinoma, small cell lung carcinoma, Ewing sarcoma, meningioma, medulloblastoma and astrocytoma.
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公开(公告)号：US20160354480A1
公开(公告)日：2016-12-08
申请号：US15111835
申请日：2015-01-19
IPC分类号： A61K47/48
摘要： The present invention relates to activated neurotensin, pharmaceutical compositions comprising the same, and the uses thereof. The compounds and compositions of the invention may be used e.g., to reduce body temperature, attenuate or halt seizures, reduce excitotoxicity, promote neuroprotection, reduce neuroinflammation and aberrant axonal sprouting or reduce pain.
摘要翻译： 本发明涉及活化的神经丝氨酸，包含其的药物组合物及其用途。 本发明的化合物和组合物可用于例如降低体温，减弱或停止癫痫发作，降低兴奋性毒性，促进神经保护作用，减少神经炎症和异常轴突发芽或减轻疼痛。
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公开(公告)号：US20130210740A1
公开(公告)日：2013-08-15
申请号：US13590661
申请日：2012-08-21
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
IPC分类号： C07K7/08
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L′, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.
摘要翻译： 描述了在人中诱导抗感受伤害的方法。 该方法包括向人以外施用有效剂量的包含L-新色氨酸的多肽的步骤。 含有L-新色氨酸的多肽可以是但不限于NT64L，NT65L，NT66L，NT67L，NT69L，NT69L'，NT71，NT72，NT73，NT74，NT75，NT76或NT77。
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5.发明申请PEPTIDE ANALOGS THAT ARE POTENT AND SELECTIVE FOR HUMAN NEUROTENSIN RECEPTOR SUBTYPE 2 审中-公开对于人神经递质受体亚型2的肽类型和选择性公开(公告)号：US20110263507A1
公开(公告)日：2011-10-27
申请号：US13177842
申请日：2011-07-07
摘要： Neurotensin analogs selective for neurotensin receptor subtype 2 are described. These include hexapeptides (NT(8-13)) and pentapeptides (NT(9-13)) having a D-3,1-naphthyl-alanine, D-3,2-naphthyl-alanine, an alanine derivative such as cyclohexylalanine, or 1,2,3,4-tetrahydroisoquinoline at position 11. Methods of treating pain by administering these neurotensin analogs are also described.
摘要翻译： 描述了对神经降压素受体亚型2有选择性的神经降压素类似物。 这些包括具有D-3,1-萘基 - 丙氨酸的六肽（NT（8-13））和五肽（NT（9-13）），D-3,2-萘基 - 丙氨酸，丙氨酸衍生物如环己基丙氨酸， 或1,2,3,4-四氢异喹啉。还描述了通过施用这些神经降压素类似物治疗疼痛的方法。
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公开(公告)号：US20110183885A1
公开(公告)日：2011-07-28
申请号：US13077028
申请日：2011-03-31
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： Methods of inducing antinociception in a human are described. The method includes the step of administering an effective dose of a polypeptide comprising L-neo-tryptophan to the human extracranially. The polypeptide containing L-neo-tryptophan could be, but is not limited to, NT64L, NT65L, NT66L, NT67L, NT69L, NT69L′, NT71, NT72, NT73, NT74, NT75, NT76, or NT77.
摘要翻译： 描述了在人中诱导抗感受伤害的方法。 该方法包括向人以外施用有效剂量的包含L-新色氨酸的多肽的步骤。 含有L-新色氨酸的多肽可以是但不限于NT64L，NT65L，NT66L，NT67L，NT69L，NT69L'，NT71，NT72，NT73，NT74，NT75，NT76或NT77。
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公开(公告)号：US07642231B2
公开(公告)日：2010-01-05
申请号：US11452616
申请日：2006-06-14
申请人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
发明人： Elliott Richelson , Bernadette Marie Cusack , Yuan-Ping Pang , Daniel J. McCormick , Abdul Fauq , Beth Marie Tyler , Mona Boules
CPC分类号： C07K7/083 , A61K38/00 , C07D209/08 , C07K7/14 , C07K7/18 , C07K14/70 , C07K14/702
摘要： The invention provides a novel amino acid, neo-tryptophan, as well as polypeptides containing this novel amino acid such as neurotensin analogs. In addition, the invention provides neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and polypeptides containing such derivatives. The invention also provides methods for making neo-tryptophan, neo-tryptophan derivatives, serotonin-like neo-tryptophan derivatives, and compositions containing these compounds. Further, the invention provides methods for inducing a neurotensin response in a mammal as well as methods for treating a mammal having a serotonin recognition molecule.
摘要翻译： 本发明提供了新的氨基酸，新色氨酸，以及含有这种新型氨基酸的多肽，如神经降压素类似物。 此外，本发明提供新色氨酸衍生物，5-羟色胺样新色氨酸衍生物和含有这些衍生物的多肽。 本发明还提供了制备新色氨酸，新色氨酸衍生物，血清素样新色氨酸衍生物和含有这些化合物的组合物的方法。 此外，本发明提供了在哺乳动物中诱导神经降压素反应的方法以及用于治疗具有5-羟色胺识别分子的哺乳动物的方法。
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8.发明申请Peptide analogs that are potent and selective for human neurotensin preceptor subtype 2 审中-公开对人类神经降压素受体亚型2有效和选择性的肽类似物公开(公告)号：US20090062212A1
公开(公告)日：2009-03-05
申请号：US11800975
申请日：2007-05-07
摘要： Neurotensin analogs selective for neurotensin receptor subtype 2 are described. These include hexapeptides (NT(8-13)) and pentapeptides (NT(9-13)) having a D-3,1-naphthyl-alanine, D-3,2-naphthyl-alanine, an alanine derivative such as cyclohexylalanine, or 1,2,3,4-tetrahydroisoquinoline at position 11. Methods of treating pain by administering these neurotensin analogs are also described.
摘要翻译： 描述了对神经降压素受体亚型2有选择性的神经降压素类似物。 这些包括具有D-3,1-萘基 - 丙氨酸的六肽（NT（8-13））和五肽（NT（9-13）），D-3,2-萘基 - 丙氨酸，丙氨酸衍生物如环己基丙氨酸， 或1,2,3,4-四氢异喹啉。还描述了通过施用这些神经降压素类似物治疗疼痛的方法。
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9.发明授权Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins 失效用于结合和/或调节受体和/或其他蛋白质的功能的肽的算法设计公开(公告)号：US07228238B2
公开(公告)日：2007-06-05
申请号：US10777829
申请日：2004-02-11
CPC分类号： G06F19/22 , C07K1/00 , C07K1/047 , C07K7/08 , C07K7/083 , C07K14/53 , C07K14/585 , G06F19/16
摘要： Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target.
摘要翻译： 基于将肽或肽样分子的一组肽组分的每个成员与靶多肽或蛋白质靶的肽组分的模式匹配来将多肽或蛋白质靶标合成肽或肽样分子的方法。
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10.发明申请Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins 审中-公开用于结合和/或调节受体和/或其他蛋白质的功能的肽的算法设计公开(公告)号：US20050119454A1
公开(公告)日：2005-06-02
申请号：US10818067
申请日：2004-04-02
申请人： Arnold Mandell , Karen Selz , Michael Shlesinger
发明人： Arnold Mandell , Karen Selz , Michael Shlesinger
IPC分类号： C07K1/00 , C07K7/08 , C07K14/53 , C07K14/585 , C07K14/705
CPC分类号： C07K7/08 , C07K1/00 , C07K7/083 , C07K14/53 , C07K14/585
摘要： Methods of synthesizing a peptide or peptide-like molecule to a polypeptide or protein target based on mode-matching each member of a set of peptide constituents of the peptide or peptide-like molecule to peptide constituents of the target polypeptide or protein target for treatment of neurological diseases.
摘要翻译： 基于将肽或肽样分子的一组肽组分的每个成员与目标多肽或蛋白质靶标的肽组分的模式匹配来将多肽或蛋白质靶标合成肽或肽样分子的方法用于治疗 神经系统疾病
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