公开(公告)号：US20230250456A1

公开(公告)日：2023-08-10

申请号：US18014674

申请日：2021-07-07

申请人： VIO CHEMICALS AG

发明人： Sven PANKE ,  Martin HELD ,  Tsvetan KARDASHLIEV

IPC分类号： C12P17/12 ,  C07D213/30 ,  C12N9/02 ,  C12N15/70 ,  C12N1/20 ,  C12N9/04

CPC分类号： C12P17/12 ,  C07D213/30 ,  C12N9/0077 ,  C12N9/0093 ,  C12N15/70 ,  C12N1/20 ,  C12N9/0006 ,  C12Y101/01021 ,  C12Y207/01017 ,  C12Y101/01001 ,  C12Y117/01

摘要： The present invention relates to the provision of an enzymatic method for the preparation of 2,6-bis(hydroxymethyl) pyridine (Formula I) using as substrate 2,6-Dimethlypyridine (2,6-lutidene) and the multicomponent xylene monooxygenase comprising XylM and XylA from Pseudomonas putida (Arthrobacter siderocapsulatus). The enzymatic method of the present invention is advantageous over conventional synthetic preparations, providing access to the title compound with a one-step enzymatic procedure.