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公开(公告)号：US20190152982A1
公开(公告)日：2019-05-23
申请号：US16301765
申请日：2017-05-16
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Yan ZHANG , Dana E. SELLEY , William DEWEY , Hamid ABKARALI
IPC: C07D489/08 , A61P25/30 , A61P25/04
Abstract: Analogues of 6 α/β-naltrexamine (NAQ) are provided. The analogues are selective, reversible antagonists of the mu opioid receptor (MOR) that exhibit good blood brain barrier penetration. The compounds are used in the treatment of opioid addiction and other diseases and conditions, including for the treatment of pain.
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