公开(公告)号：US09777123B2

公开(公告)日：2017-10-03

申请号：US14889870

申请日：2014-05-29

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Umesh R. Desai ,  Jay Thakkar ,  Akul Mehta

IPC: C07G1/00 ,  C08H7/00 ,  C07C305/22

CPC classification number: C08H6/00 ,  C07C305/22

Abstract: Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.

公开(公告)号：US08993620B2

公开(公告)日：2015-03-31

申请号：US14087706

申请日：2013-11-22

Applicant: Virginia Commonwealth University

Inventor： Umesh R. Desai ,  Brian L. Henry ,  Aiye Liang ,  Jay Thakkar ,  John B. Mangrum ,  Ivo Torres Filho ,  Bruce D. Spiess ,  Masahiro Sakagami ,  Bhawana Saluja

IPC: A61K31/185 ,  A61K31/192 ,  A61K31/343 ,  C07C305/24 ,  C07D407/14 ,  A61K9/00 ,  C07D307/80 ,  C07D307/84

CPC classification number: C07D407/14 ,  A61K9/007 ,  A61K31/185 ,  A61K31/192 ,  A61K31/343 ,  C07C305/24 ,  C07D307/80 ,  C07D307/84

Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.

Abstract translation: 提供肉桂酸类低聚物及其治疗用途。 低聚物用作抗炎剂，弹性蛋白酶和抗氧化剂的抑制剂，并且在一些情况下（例如治疗肺部疾病如肺癌），所有这三种活性同时是有益的。 低聚物（例如＆bgr; -O4和＆bgr; -5 +三聚体和四聚体）的亚类被用作抗凝剂。

公开(公告)号：US20140080904A1

公开(公告)日：2014-03-20

申请号：US14087706

申请日：2013-11-22

Applicant: Virginia Commonwealth University

Inventor： Umesh R. Desai ,  Brian L. Henry ,  Aiye Liang ,  Jay Thakkar ,  John B. Mangrum ,  Ivo Torres Filho ,  Bruce D. Spiess ,  Masahiro Sakagami ,  Bhawana Saluja

IPC: C07D307/84

CPC classification number: C07D407/14 ,  A61K9/007 ,  A61K31/185 ,  A61K31/192 ,  A61K31/343 ,  C07C305/24 ,  C07D307/80 ,  C07D307/84

Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.

Abstract translation: 提供肉桂酸类低聚物及其治疗用途。 低聚物用作抗炎剂，弹性蛋白酶和抗氧化剂的抑制剂，并且在一些情况下（例如治疗肺部疾病如肺癌），所有这三种活性同时是有益的。 低聚物（例如＆bgr; -O4和＆bgr; -5 +三聚体和四聚体）的亚类被用作抗凝剂。

公开(公告)号：US20160115280A1

公开(公告)日：2016-04-28

申请号：US14889870

申请日：2014-05-29

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Umesh R. Desai ,  Jay Thakkar ,  Akul Mehta

IPC: C08H7/00

CPC classification number: C08H6/00 ,  C07C305/22

Abstract: Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.

Abstract translation: 低分子量硫酸化β-O4木质素（SbO4L）是高选择性凝结的有效抑制剂。

公开(公告)号：US08613909B2

公开(公告)日：2013-12-24

申请号：US13926008

申请日：2013-06-25

Applicant: Virginia Commonwealth University

Inventor： Umesh R. Desai ,  Brian L. Henry ,  Aiye Liang ,  Jay Thakkar ,  John B. Mangrum ,  Ivo Torres Filho ,  Bruce D. Spiess ,  Masahiro Sakagami ,  Bhawana Saluja

IPC: A61K9/12 ,  A61K31/185 ,  A61K31/192 ,  A61K31/343 ,  A61K31/255 ,  C07C305/24 ,  C07D307/80 ,  C07D307/84 ,  C07D407/14 ,  A61P7/02 ,  A61P29/00 ,  A61P11/00

CPC classification number: C07D407/14 ,  A61K9/007 ,  A61K31/185 ,  A61K31/192 ,  A61K31/343 ,  C07C305/24 ,  C07D307/80 ,  C07D307/84

Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.