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公开(公告)号：US09850221B2
公开(公告)日：2017-12-26
申请号：US15034232
申请日：2014-11-07
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Umesh R. Desai , Rajesh Karuturi , Bhaumik B. Patel , Nirmita J. Patel
IPC: C07D311/30 , C07D405/12 , C07D407/12
CPC classification number: C07D311/30 , C07D405/12 , C07D407/12
Abstract: Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to selectively inhibit CSCs growth and self-renewal both in vitro and in vivo.
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公开(公告)号：US09777123B2
公开(公告)日：2017-10-03
申请号：US14889870
申请日：2014-05-29
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Umesh R. Desai , Jay Thakkar , Akul Mehta
IPC: C07G1/00 , C08H7/00 , C07C305/22
CPC classification number: C08H6/00 , C07C305/22
Abstract: Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.
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3.发明申请NANOSENSOR FOR DETECTING THE ACTIVITY OF GLYCOSAMINOGLYCAN-CLEAVING ENZYMES AND USES THEREOF 审中-公开用于检测糖蛋白酶清除酶活性的纳米传感器及其用途公开(公告)号：US20160201112A1
公开(公告)日：2016-07-14
申请号：US14912408
申请日：2014-09-08
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Umesh R. Desai , Mausam Kalita , Kuberan Balagurunathan
CPC classification number: C12Q1/527 , C08B37/0075 , G01N21/6428 , G01N33/582 , G01N33/86 , G01N2021/6432 , G01N2021/6439 , G01N2333/988 , G01N2400/40
Abstract: High sensitivity nanosensors for detecting the inhibition of glycosaminoglycan (GAG)-cleaving enzymes are provided. Methods of using the nanosensors include detecting contaminants in commercial GAG preparations (e.g. heparin preparations) by measuring the activity levels of a GAG)-cleaving enzyme in the presence of a sample which may contain a contaminant that inhibits the GAG-cleaving enzyme.
Abstract translation: 提供了用于检测糖胺聚糖（GAG）消除酶抑制的高灵敏度纳米传感器。 使用纳米传感器的方法包括通过在可能含有抑制GAG切割酶的污染物的样品存在下测量GAG消除酶的活性水平来检测商业GAG制剂（例如肝素制剂）中的污染物。
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公开(公告)号：US08993620B2
公开(公告)日：2015-03-31
申请号：US14087706
申请日：2013-11-22
Applicant: Virginia Commonwealth University
Inventor： Umesh R. Desai , Brian L. Henry , Aiye Liang , Jay Thakkar , John B. Mangrum , Ivo Torres Filho , Bruce D. Spiess , Masahiro Sakagami , Bhawana Saluja
IPC: A61K31/185 , A61K31/192 , A61K31/343 , C07C305/24 , C07D407/14 , A61K9/00 , C07D307/80 , C07D307/84
CPC classification number: C07D407/14 , A61K9/007 , A61K31/185 , A61K31/192 , A61K31/343 , C07C305/24 , C07D307/80 , C07D307/84
Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.
Abstract translation: 提供肉桂酸类低聚物及其治疗用途。 低聚物用作抗炎剂，弹性蛋白酶和抗氧化剂的抑制剂，并且在一些情况下（例如治疗肺部疾病如肺癌），所有这三种活性同时是有益的。 低聚物（例如＆bgr; -O4和＆bgr; -5 +三聚体和四聚体）的亚类被用作抗凝剂。
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公开(公告)号：US20140080904A1
公开(公告)日：2014-03-20
申请号：US14087706
申请日：2013-11-22
Applicant: Virginia Commonwealth University
Inventor： Umesh R. Desai , Brian L. Henry , Aiye Liang , Jay Thakkar , John B. Mangrum , Ivo Torres Filho , Bruce D. Spiess , Masahiro Sakagami , Bhawana Saluja
IPC: C07D307/84
CPC classification number: C07D407/14 , A61K9/007 , A61K31/185 , A61K31/192 , A61K31/343 , C07C305/24 , C07D307/80 , C07D307/84
Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.
Abstract translation: 提供肉桂酸类低聚物及其治疗用途。 低聚物用作抗炎剂，弹性蛋白酶和抗氧化剂的抑制剂，并且在一些情况下（例如治疗肺部疾病如肺癌），所有这三种活性同时是有益的。 低聚物（例如＆bgr; -O4和＆bgr; -5 +三聚体和四聚体）的亚类被用作抗凝剂。
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Patent Agency Ranking
公开(公告)号：US09758459B2
公开(公告)日：2017-09-12
申请号：US14442100
申请日：2013-11-12
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Umesh R. Desai , Rajesh Karuturi , Akul Mehta , Rami A. Al-Horani
IPC: C07C35/16 , C07H13/08 , C07C69/757 , C07C309/58 , C07D239/91 , C07D403/12 , C07D403/14 , C07D405/14
CPC classification number: C07C35/16 , C07C69/757 , C07C309/58 , C07C2601/14 , C07D239/91 , C07D403/12 , C07D403/14 , C07D405/14 , C07H13/08
Abstract: Compounds which allosterically modulate and/or inhibit factor XIa activity are provided, as are methods of their use. These compounds include i) sulfated gallolyl glucosides, ii) sulfated quinazolinones, and iii) sulfated inositol analogs. The compounds used as anticoagulant agents.
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公开(公告)号：US20170058319A1
公开(公告)日：2017-03-02
申请号：US15123079
申请日：2015-03-25
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Umesh R. Desai , Bruce D. Spiess , Donald F. Brophy , Erika J. Martin , Kuberan Balagurunathan
CPC classification number: C12Q1/56 , C12N9/6429 , C12Y304/21005 , G01N21/6428 , G01N33/542 , G01N33/582 , G01N33/587 , G01N33/86 , G01N2021/6432 , G01N2021/6439 , G01N2333/974
Abstract: Constructs and monitoring systems to assess the level of molecules that bind to thrombin (e.g. thrombin regulators and inhibitors) are provided. The constructs are nanosensors comprising i) a thrombin molecule to which is bound a reporter ligand comprising a fluorescent label, ii) a fluorescence-quenching metal nanoparticle, and, optionally iii) a fluorescence-quenching dye molecule attached to one or both of the nanoparticle and the thrombin molecule. The binding of a thrombin regulator or inhibitor to the thrombin molecule displaces the reporter ligand, and the signal from the fluorescent label increases. The increase is proportional to the concentration of thrombin-binding molecule in the sample.
Abstract translation: 提供了构建和监测系统以评估与凝血酶结合的分子的水平（例如凝血酶调节剂和抑制剂）。 所述构建体是纳米传感器，其包含i）结合了包含荧光标记的报告基因配体的凝血酶分子，ii）荧光猝灭金属纳米颗粒，以及任选的iii）连接到所述纳米颗粒中的一个或两个的荧光猝灭染料分子 和凝血酶分子。 凝血酶调节剂或抑制剂与凝血酶分子的结合取代了报道配体，并且来自荧光标记的信号增加。 增加与样品中凝血酶结合分子的浓度成比例。
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公开(公告)号：US08613909B2
公开(公告)日：2013-12-24
申请号：US13926008
申请日：2013-06-25
Applicant: Virginia Commonwealth University
Inventor： Umesh R. Desai , Brian L. Henry , Aiye Liang , Jay Thakkar , John B. Mangrum , Ivo Torres Filho , Bruce D. Spiess , Masahiro Sakagami , Bhawana Saluja
IPC: A61K9/12 , A61K31/185 , A61K31/192 , A61K31/343 , A61K31/255 , C07C305/24 , C07D307/80 , C07D307/84 , C07D407/14 , A61P7/02 , A61P29/00 , A61P11/00
CPC classification number: C07D407/14 , A61K9/007 , A61K31/185 , A61K31/192 , A61K31/343 , C07C305/24 , C07D307/80 , C07D307/84
Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. β-O4 and β-5 trimers and tetramers) are used as anticoagulants.
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公开(公告)号：US20160280676A1
公开(公告)日：2016-09-29
申请号：US15034232
申请日：2014-11-07
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Umesh R. Desai , Rajesh Karuturi , Bhaumik B. Patel , Nirmita J. Patel
IPC: C07D311/30 , C07D405/12
CPC classification number: C07D311/30 , C07D405/12 , C07D407/12
Abstract: Sulfated and unsulfated flavonoid oligomers as inhibitors of cancer stem cells (CSCs) are provided. In particular, sulfated flavonoid dimers are shown to selectively inhibit CSCs growth and self-renewal both in vitro and in vivo.
Abstract translation: 提供硫酸化和未硫酸化的类黄酮低聚物作为癌症干细胞（CSCs）的抑制剂。 特别地，硫酸化类黄酮二聚体显示出在体外和体内都选择性地抑制CSCs生长和自我更新。
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公开(公告)号：US20160115280A1
公开(公告)日：2016-04-28
申请号：US14889870
申请日：2014-05-29
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Umesh R. Desai , Jay Thakkar , Akul Mehta
IPC: C08H7/00
CPC classification number: C08H6/00 , C07C305/22
Abstract: Low molecular weight sulfated beta-O4 lignin (SbO4L) are potent inhibitors of coagulation with high selectivity.
Abstract translation: 低分子量硫酸化β-O4木质素（SbO4L）是高选择性凝结的有效抑制剂。
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