公开(公告)号：US11661433B2

公开(公告)日：2023-05-30

申请号：US17053837

申请日：2019-05-09

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Matthew Hartman ,  Koushambi Mitra

IPC: C07F15/00 ,  A61K31/282 ,  A61K41/00

CPC classification number: C07F15/0093 ,  A61K31/282 ,  A61K41/0042 ,  A61K41/0057

Abstract: Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.

公开(公告)号：US20210238211A1

公开(公告)日：2021-08-05

申请号：US17053837

申请日：2019-05-09

Applicant: VIRGINIA COMMONWEALTH UNIVERSITY

Inventor： Matthew Hartman ,  Koushambi Mitra

IPC: C07F15/00 ,  A61K41/00 ,  A61K31/282

Abstract: Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.