-
公开(公告)号：US20140236071A1
公开(公告)日：2014-08-21
申请号：US14347656
申请日：2012-09-28
Applicant: Virginia Commonwealth University
Inventor： Matthew Hartman , Martin Michael Dcona , Deboleena Mitra
CPC classification number: A61K47/48023 , A61K31/704 , A61K41/0042 , A61K47/54 , A61K47/62 , A61K47/65 , A61N5/062
Abstract: Conjugates are provided which comprise a membrane permeable drug linked to a moiety that is not membrane permeable. Attachment of the moiety that is not membrane permeable prevents the drug from crossing cell membranes and entering cells. However, exposure to light either i) breaks the linkage, releasing the drug and allowing it to enter cells; or ii) converts the non-membrane permeable moiety to a membrane permeable form, allowing the entire conjugate to enter the cell, where the drug is released from the conjugate by cleavage. The membrane permeable drugs are thus delivered to cells at locations of interest, e.g. cancer cells in a tumor, in a temporally and spatially controlled manner.
Abstract translation: 提供了缀合物，其包含连接到不透膜的部分的膜可渗透药物。 不透膜部分的附着防止药物穿过细胞膜并进入细胞。 然而，暴露于光，或者i）断开连接，释放药物并允许其进入细胞; 或ii）将非膜可渗透部分转化为膜可渗透形式，允许整个缀合物进入细胞，其中药物通过切割从缀合物释放。 因此，膜渗透性药物被递送到感兴趣的位置的细胞，例如， 肿瘤中的癌细胞，以时间和空间方式控制。
-
公开(公告)号：US20210238211A1
公开(公告)日：2021-08-05
申请号：US17053837
申请日：2019-05-09
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Matthew Hartman , Koushambi Mitra
IPC: C07F15/00 , A61K41/00 , A61K31/282
Abstract: Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.
-
公开(公告)号：US09364551B2
公开(公告)日：2016-06-14
申请号：US14347656
申请日：2012-09-28
Applicant: Virginia Commonwealth University
Inventor： Matthew Hartman , Martin Michael Dcona , Deboleena Mitra
CPC classification number: A61K47/48023 , A61K31/704 , A61K41/0042 , A61K47/54 , A61K47/62 , A61K47/65 , A61N5/062
Abstract: Conjugates are provided which comprise a membrane permeable drug linked to a moiety that is not membrane permeable. Attachment of the moiety that is not membrane permeable prevents the drug from crossing cell membranes and entering cells. However, exposure to light either i) breaks the linkage, releasing the drug and allowing it to enter cells; or ii) converts the non-membrane permeable moiety to a membrane permeable form, allowing the entire conjugate to enter the cell, where the drug is released from the conjugate by cleavage. The membrane permeable drugs are thus delivered to cells at locations of interest, e.g. cancer cells in a tumor, in a temporally and spatially controlled manner.
Abstract translation: 提供了缀合物，其包含连接到不透膜的部分的膜可渗透药物。 不透膜部分的附着防止药物穿过细胞膜并进入细胞。 然而，暴露于光，或者i）断开连接，释放药物并使其进入细胞; 或ii）将非膜可渗透部分转化为膜可渗透形式，允许整个缀合物进入细胞，其中药物通过切割从缀合物释放。 因此，膜渗透性药物被递送到感兴趣的位置的细胞，例如， 肿瘤中的癌细胞，以时间和空间方式控制。
-
公开(公告)号：US11661433B2
公开(公告)日：2023-05-30
申请号：US17053837
申请日：2019-05-09
Applicant: VIRGINIA COMMONWEALTH UNIVERSITY
Inventor： Matthew Hartman , Koushambi Mitra
IPC: C07F15/00 , A61K31/282 , A61K41/00
CPC classification number: C07F15/0093 , A61K31/282 , A61K41/0042 , A61K41/0057
Abstract: Near-infrared activatable fluorescent small molecules for the photodynamic treatment of cancer are provided. Methods of treatment include contacting a plurality of cells of the cancer with a near-infrared activatable fluorescent small molecule and directing a near-IR light to the molecule for an amount of time sufficient to induce release of the active platinum species and a reactive oxygen species.
-
-
-
Search Results
4
records
(took 0.013 seconds)
