-
公开(公告)号：US08213005B2
公开(公告)日：2012-07-03
申请号：US12654782
申请日：2009-12-31
IPC分类号： G01J3/30
CPC分类号： G01N21/6486 , G01N33/57434
摘要： The method for discriminating between benign and malignant prostate tumors relates to analyzing samples of blood, urine and tissue by fluorescence spectroscopy in order to detect the presence of naturally occurring molecules in the fluids and tissue that serve as biomarkers indicative of cancer in the human body. The analysis can be carried out based on fluorescence emission spectra, fluorescence excitation spectra and synchronous (emission and excitation) spectra of bio-samples. The detection, diagnosis, and follow-up and also discrimination between malignant and benign prostate tumors may be made by comparison of ratios of fluorescence emissions and/or excitation intensities of tryptophan, tyrosine, elastin, collagen, bile pigments, NADH, flavins and various species of porphyrins.
摘要翻译： 用于区分良性和恶性前列腺肿瘤的方法涉及通过荧光光谱分析血液，尿液和组织的样品，以便检测作为指示人体癌症的生物标志物的流体和组织中天然存在的分子的存在。 该分析可以基于荧光发射光谱，荧光激发光谱和生物样品的同步（发射和激发）光谱进行。 可以通过比较色氨酸，酪氨酸，弹性蛋白，胶原，胆汁颜料，NADH，黄素和各种颜色的荧光发射和/或激发强度的比例来进行恶性和良性前列腺肿瘤之间的检测，诊断和随访以及恶性和良性前列腺肿瘤的鉴别 卟啉物种
-
公开(公告)号：US20100173350A1
公开(公告)日：2010-07-08
申请号：US12654782
申请日：2009-12-31
IPC分类号： C12Q1/02
CPC分类号： G01N21/6486 , G01N33/57434
摘要： The method for discriminating between benign and malignant prostate tumors relates to analyzing samples of blood, urine and tissue by fluorescence spectroscopy in order to detect the presence of naturally occurring molecules in the fluids and tissue that serve as biomarkers indicative of cancer in the human body. The analysis can be carried out based on fluorescence emission spectra, fluorescence excitation spectra and synchronous (emission and excitation) spectra of bio-samples. The detection, diagnosis, and follow-up and also discrimination between malignant and benign prostate tumors may be made by comparison of ratios of fluorescence emissions and/or excitation intensities of tryptophan, tyrosine, elastin, collagen, bile pigments, NADH, flavins and various species of porphyrins.
摘要翻译： 用于区分良性和恶性前列腺肿瘤的方法涉及通过荧光光谱分析血液，尿液和组织的样品，以便检测作为指示人体癌症的生物标志物的流体和组织中天然存在的分子的存在。 该分析可以基于荧光发射光谱，荧光激发光谱和生物样品的同步（发射和激发）光谱进行。 可以通过比较色氨酸，酪氨酸，弹性蛋白，胶原，胆汁颜料，NADH，黄素和各种颜色的荧光发射和/或激发强度的比例来进行恶性和良性前列腺肿瘤之间的检测，诊断和随访以及恶性和良性前列腺肿瘤的鉴别 卟啉物种
-
公开(公告)号：US07869033B2
公开(公告)日：2011-01-11
申请号：US12285670
申请日：2008-10-10
IPC分类号： G01N21/64
CPC分类号： G01N21/6486
摘要： The optical analysis of body fluids is a method of determining the relative concentration of certain bio-molecules in blood and urine samples by fluorescent spectroscopy. The relative concentration of these bio-molecules serves as a marker or screening test to assess the presence and stage of cancer in some organ or tissue of the body, and in some cases, the presence of particular types of cancer in the body. The bio-molecules include various species of porphyrin, flavins (including flavin mononucleotide[FMN], flavin adeno dinucleotide [FAD], and riboflavin), bile components (including biliverdin and bilirubin), tyrosine, tryptophan, and NAD(P)H. The fluorescent spectroscopy techniques include determining intensity maxima in the emission spectra at particular excitation wavelengths characteristic of the bio-molecules, determining intensity maxima in the excitation spectra at particular emission wavelengths characteristic of the bio-molecules, and synchronous scanning of the excitation and emission spectra while maintaining particular offsets in the wavelengths.
摘要翻译： 体液的光学分析是通过荧光光谱法测定血液和尿液样品中某些生物分子的相对浓度的方法。 这些生物分子的相对浓度用作标记或筛选试验，以评估身体的某些器官或组织中癌症的存在和阶段，并且在一些情况下，在体内存在特定类型的癌症。 生物分子包括各种卟啉，黄素（包括黄素单核苷酸[FMN]，黄素腺苷二核苷酸[FAD]和核黄素），胆汁成分（包括胆红素和胆红素），酪氨酸，色氨酸和NAD（P）H。 荧光光谱技术包括确定生物分子特征的特定激发波长处的发射光谱中的强度最大值，确定生物分子特征发射波长处的激发光谱中的强度最大值，以及激发和发射光谱的同步扫描 同时保持波长中的特定偏移。
-
公开(公告)号：US08208142B2
公开(公告)日：2012-06-26
申请号：US12591749
申请日：2009-11-30
IPC分类号： G01N21/25
CPC分类号： G01N33/57423 , G01N2800/50 , G01N2800/56
摘要： The method for lung cancer detection by optical analysis of body fluids relates to analyzing samples of blood, urine and sputum by fluorescence spectroscopy in order to detect the presence of naturally occurring molecules in the fluids that serve as biomarkers indicative of cancer in the human body. The analysis can be carried out based on fluorescence emission spectra, fluorescence excitation spectra and synchronous (emission and excitation) spectra of bio-samples. The early detection and diagnosis of lung cancer may be made by comparison of ratios of fluorescence emissions and/or excitation intensities of tryptophan, tyrosine, elastin, collagen, bile pigments, NADPH, flavins and various species of porphyrins.
摘要翻译： 通过体液光学分析进行肺癌检测的方法涉及通过荧光光谱法分析血液，尿液和痰液的样品，以便检测作为指示人体癌症的生物标志物的流体中天然存在的分子的存在。 该分析可以基于荧光发射光谱，荧光激发光谱和生物样品的同步（发射和激发）光谱进行。 可以通过比较色氨酸，酪氨酸，弹性蛋白，胶原，胆汁颜料，NADPH，黄素和各种卟啉的荧光发射和/或激发强度的比例来进行肺癌的早期检测和诊断。
-
公开(公告)号：US20100075367A1
公开(公告)日：2010-03-25
申请号：US12591749
申请日：2009-11-30
CPC分类号： G01N33/57423 , G01N2800/50 , G01N2800/56
摘要： The method for lung cancer detection by optical analysis of body fluids relates to analyzing samples of blood, urine and sputum by fluorescence spectroscopy in order to detect the presence of naturally occurring molecules in the fluids that serve as biomarkers indicative of cancer in the human body. The analysis can be carried out based on fluorescence emission spectra, fluorescence excitation spectra and synchronous (emission and excitation) spectra of bio-samples. The early detection and diagnosis of lung cancer may be made by comparison of ratios of fluorescence emissions and/or excitation intensities of tryptophan, tyrosine, elastin, collagen, bile pigments, NADPH, flavins and various species of porphyrins.
摘要翻译： 通过体液光学分析进行肺癌检测的方法涉及通过荧光光谱法分析血液，尿液和痰液的样品，以便检测作为指示人体癌症的生物标志物的流体中天然存在的分子的存在。 该分析可以基于荧光发射光谱，荧光激发光谱和生物样品的同步（发射和激发）光谱进行。 可以通过比较色氨酸，酪氨酸，弹性蛋白，胶原，胆汁颜料，NADPH，黄素和各种卟啉的荧光发射和/或激发强度的比例来进行肺癌的早期检测和诊断。
-
公开(公告)号：US20090046286A1
公开(公告)日：2009-02-19
申请号：US12285670
申请日：2008-10-10
IPC分类号： G01J3/30
CPC分类号： G01N21/6486
摘要： The optical analysis of body fluids is a method of determining the relative concentration of certain bio-molecules in blood and urine samples by fluorescent spectroscopy. The relative concentration of these bio-molecules serves as a marker or screening test to assess the presence and stage of cancer in some organ or tissue of the body, and in some cases, the presence of particular types of cancer in the body. The bio-molecules include various species of porphyrin, flavins (including flavin mononucleotide[FMN], flavin adeno dinucleotide [FAD], and riboflavin), bile components (including biliverdin and bilirubin), tyrosine, tryptophan, and NAD(P)H. The fluorescent spectroscopy techniques include determining intensity maxima in the emission spectra at particular excitation wavelengths characteristic of the bio-molecules, determining intensity maxima in the excitation spectra at particular emission wavelengths characteristic of the bio-molecules, and synchronous scanning of the excitation and emission spectra while maintaining particular offsets in the wavelengths.
摘要翻译： 体液的光学分析是通过荧光光谱法测定血液和尿液样品中某些生物分子的相对浓度的方法。 这些生物分子的相对浓度用作标记或筛选试验，以评估身体的某些器官或组织中癌症的存在和阶段，并且在一些情况下，在体内存在特定类型的癌症。 生物分子包括各种卟啉，黄素（包括黄素单核苷酸[FMN]，黄素腺苷二核苷酸[FAD]和核黄素），胆汁成分（包括胆红素和胆红素），酪氨酸，色氨酸和NAD（P）H。 荧光光谱技术包括确定生物分子特征的特定激发波长处的发射光谱中的强度最大值，确定生物分子特征发射波长处的激发光谱中的强度最大值，以及激发和发射光谱的同步扫描 同时保持波长中的特定偏移。
-
7.发明授权公开(公告)号：US09347885B2
公开(公告)日：2016-05-24
申请号：US13889306
申请日：2013-05-07
CPC分类号： G01N21/6486 , G01N33/492 , G01N33/6812
摘要： The method of detecting thalassemia by optical analysis of blood components is a spectral detection method that is based on the fluorescence spectra of a set of biomolecules, including tyrosine, tryptophan, nicotinamide adenine dinucleotide, and flavin adenine dinucleotide, which are all found in blood plasma, and porphyrin, which is found in red blood cells (RBCs). Measured ratios of intensity maxima between tryptophan and nicotinamide adenine dinucleotide, flavin adenine dinucleotide and nicotinamide adenine dinucleotide, tyrosine and tryptophan, and the normal form of porphyrin and the basic form of porphyrin may each be used, alone or in combination, to diagnose a patient as suffering from thalassemia.
摘要翻译： 通过血液成分的光学分析检测地中海贫血的方法是基于一组生物分子的荧光光谱的光谱检测方法，包括酪氨酸，色氨酸，烟酰胺腺嘌呤二核苷酸和黄素腺嘌呤二核苷酸，其均在血浆中发现 和卟啉，其在红细胞（RBC）中发现。 色氨酸和烟酰胺腺嘌呤二核苷酸，黄素腺嘌呤二核苷酸和烟酰胺腺嘌呤二核苷酸，酪氨酸和色氨酸之间的强度最大值和卟啉的正常形式和卟啉的基本形式的测量比可以单独或组合地用于诊断患者 因为患有地中海贫血。
-
公开(公告)号：US20060170928A1
公开(公告)日：2006-08-03
申请号：US11017913
申请日：2004-12-22
IPC分类号： G01J3/45
CPC分类号： G01J3/4406 , G01N21/6486
摘要： An apparatus for optical analysis of body fluids for cancer detection comprising: a light source for generating light rays,(incoherent lamp or laser) an excitation wavelength determination means, a grating for receiving optical rays from the body fluids, said optical rays being received at right angles to the optical rays incident on the said body fluids, an optical conversion means for receiving optical rays of from the said grating and converting the said optical rays to electrical signals, a computer for receiving and processing said the electrical signals. And the technique and process of the following preparing the blood and urine samples and their extracts. obtaining emission excitation and synchronous spectra. ratio fluorometry to identify the spectral signature of cancer specific molecules such as Porphyrin, Billurubin, Billiverdin, Riboflavin, Tryptophane, NAD(P)H etc. evaluating pre-malignant, early and advanced stages of cancer of any etiology.
摘要翻译： 一种用于癌症检测的体液的光学分析装置，包括：用于产生光线的光源（非相干灯或激光）激发波长确定装置，用于从体液接收光线的光栅，所述光线被接收在 与入射在所述体液上的光线成直角的光转换装置，用于接收来自所述光栅的光线并将所述光线转换成电信号的光转换装置，用于接收和处理所述电信号的计算机。 以及以下制备血液和尿液样品及其提取物的技术和方法。 获得发射激发和同步光谱。 比较荧光测定以鉴定癌症特异性分子如卟啉，Billurubin，Billiverdin，核黄素，色氨酸，NAD（P）H等的光谱特征，评估任何病因的恶性，早期和晚期癌症。
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.015 秒)
