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    Fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
    4.
    发明申请
    Fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth 审中-公开
    脂肪酶的发酵过程和从发酵液中提取脂肪抑制素的方法

    公开(公告)号：US20050089978A1

    公开(公告)日：2005-04-28

    申请号：US10994268

    申请日：2004-11-23

    申请人： Janos Erdei ,  Eva Gulyas ,  Gabor Balogh ,  Laszlo Toth ,  Vilmos Keri ,  Andrea Csorvasi

    发明人： Janos Erdei ,  Eva Gulyas ,  Gabor Balogh ,  Laszlo Toth ,  Vilmos Keri ,  Andrea Csorvasi

    IPC分类号： C07D305/12 ,  C12P17/02 ,  C12P7/64 ,  C12P17/06

    CPC分类号： C12P17/02 ,  C07D305/12

    摘要： The present invention provides a fermentation process for producing lipstatin comprising the steps of: a) preparing a fermentation medium containing a lipstatin-producing microorganism comprising an oil and an assimilable carbon source, wherein the wt/wt ratio of oil and assimilable carbon source is regulated to achieve an optimal lipstatin biosynthesis by the microorganism; and b) feeding the fermentation medium with an emulsifier, wherein the emulsifier provides an optimal viscosity for the fermentation medium and optimal pH during the fermentation to permit fermentation for lipstatin production. The disclosed process also provides a process for extracting a lipstatin from a fermentation broth.

    摘要翻译： 本发明提供了一种用于制备口服抑制素的发酵方法，包括以下步骤：a）制备含有产生脂质体抑制素的微生物的发酵培养基，其包含油和可同化碳源，其中油和可同化碳源的wt / wt比例被调节 实现微生物的最佳脂肪酶抑制素生物合成; 和b）向所述发酵培养基中加入乳化剂，其中所述乳化剂为所述发酵培养基提供最佳粘度，并且在所述发酵期间提供最佳pH以允许发酵用于脂质体抑制素生产。 所公开的方法还提供了从发酵液中提取脂肪抑制素的方法。

    pH controlled fermentation process for pseudomonic acid production
    6.
    发明授权
    pH controlled fermentation process for pseudomonic acid production 失效
    用于假肌酸生产的pH控制发酵过程

    公开(公告)号：US07439045B2

    公开(公告)日：2008-10-21

    申请号：US10177026

    申请日：2002-06-21

    申请人： Eva Gulyas ,  Gabor Balogh ,  Janos Erdei ,  Peter Seress

    发明人： Eva Gulyas ,  Gabor Balogh ,  Janos Erdei ,  Peter Seress

    IPC分类号： C12P17/16

    CPC分类号： C12N1/20 ,  C12P17/162

    摘要： An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.

    摘要翻译： 公开了用于制备假单胞菌酸A（莫匹罗星）的改进的发酵方法。 代谢控制的发酵过程提供培养假单胞菌属（Pseudomonas sp。 在20-30℃左右的温度下浸没培养基中的菌株。通过向发酵培养基中加入可同化的碳源，矿物盐或酸性/盐酸盐，将发酵培养基的pH调节至约5.5-6.0。 碱溶液。 因此，所得发酵液含有高纯度假单胞菌酸A作为主要成分的增加的产率。 在发酵液中作为杂质的假单胞菌酸B显着降低。