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    Inversion on chromosome 8p23 is a risk factor for anxiety disorders, depression and bipolar disorders
    3.
    发明申请
    Inversion on chromosome 8p23 is a risk factor for anxiety disorders, depression and bipolar disorders 审中-公开
    8p23染色体上的反转是焦虑症，抑郁症和双相性精神障碍的危险因素

    公开(公告)号：US20070111209A1

    公开(公告)日：2007-05-17

    申请号：US10571865

    申请日：2004-09-17

    申请人： Soley Bjornsdottir ,  Augustine Kong ,  Thorgeir Thorgeirsson

    发明人： Soley Bjornsdottir ,  Augustine Kong ,  Thorgeir Thorgeirsson

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

    摘要： An association between psychiatric disorders and disorders comorbid with psychiatric disorders, and genetic markers in the 8p23 genomic region is described. Markers are also provided to diagnose or detect a susceptibility to disorders comorbid with panic disorder and independently of comorbidity with panic disorder. Methods and surrogate markers for detecting the orientation of the Inv8p23 inversion fragment, thereby diagnosing psychiatric disorders or comorbid disorders or a susceptibility to psychiatric disorders or comorbid disorders, are also disclosed. The methods described herein are also useful for determining responsiveness of drugs useful for treating psychiatric disorders.

    摘要翻译： 描述了精神障碍和与精神疾病共存的疾病之间的关联，以及8p23基因组区域中的遗传标记。 还提供标记物以诊断或检测与恐慌症并发症并发症和惊恐障碍并发症的易感性。 还公开了用于检测Inv8p23反转片段取向的方法和替代标记，从而诊断精神疾病或并发症，或对精神病或合并病症的易感性。 本文描述的方法也可用于确定用于治疗精神疾病的药物的反应性。

    Methods for diagnosing and characterizing breast cancer and susceptibility to breast cancer
    5.
    发明申请
    Methods for diagnosing and characterizing breast cancer and susceptibility to breast cancer 审中-公开
    诊断和鉴定乳腺癌和乳腺癌易感性的方法

    公开(公告)号：US20070092900A1

    公开(公告)日：2007-04-26

    申请号：US11515368

    申请日：2006-08-31

    申请人： Simon Stacey ,  Patrick Sulem ,  Unnur Thorsteinsdottir ,  Augustine Kong

    发明人： Simon Stacey ,  Patrick Sulem ,  Unnur Thorsteinsdottir ,  Augustine Kong

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/172 ,  G01N33/57415

    摘要： Methods and kits for diagnosing and characterizing breast cancer or a susceptibility to breast cancer are described herein. Diagnosis and characterization methods comprise detecting the BARD1 Cys557Ser allele or a haplotype comprising the BARD1 Cys557Ser allele in patients with or without a familial predisposition to cancer. The methods described herein further allow for the characterization of a tumor as invasive or non-invasive, and allow for the prediction of whether a patient who has a primary tumor is likely to develop a second primary tumor.

    摘要翻译： 本文描述了用于诊断和表征乳腺癌或乳腺癌易感性的方法和试剂盒。 诊断和表征方法包括在有或没有家族性癌症倾向的患者中检测BARD1 Cys557Ser等位基因或包含BARD1 Cys557Ser等位基因的单体型。 本文描述的方法还允许将肿瘤表征为侵入性或非侵入性的，并且允许预测具有原发性肿瘤的患者是否可能形成第二原发性肿瘤。