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公开(公告)号：US20210244717A1
公开(公告)日：2021-08-12
申请号：US17018196
申请日：2020-09-11
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US20210246147A1
公开(公告)日：2021-08-12
申请号：US17022906
申请日：2020-09-16
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Judith D. Kuntz , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng
IPC分类号： C07D519/00 , C07D215/48 , C07D471/04 , C07D513/04 , A61K31/4545 , A61K31/5377 , A61K45/06 , A61K31/437 , A61K31/4709 , A61K31/497 , C07D495/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)
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公开(公告)号：US20180291000A1
公开(公告)日：2018-10-11
申请号：US16008378
申请日：2018-06-14
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号： C07D401/12 , C07C317/42 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D213/84 , C07D213/81 , C07D213/75 , C07D213/74 , C07D213/54 , C07D213/40
CPC分类号： C07D401/12 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07C317/42 , C07D213/40 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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公开(公告)号：US20230346753A1
公开(公告)日：2023-11-02
申请号：US18073768
申请日：2022-12-02
申请人： Valo Health, Inc. , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4355 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D491/048
CPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US10647695B2
公开(公告)日：2020-05-12
申请号：US16419333
申请日：2019-05-22
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号： C07D401/12 , C07D471/04 , C07D213/75 , C07D213/40 , C07D213/81 , C07C317/42 , C07D213/54 , C07D213/74 , C07D213/84 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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公开(公告)号：US10772874B2
公开(公告)日：2020-09-15
申请号：US16538208
申请日：2019-08-12
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： C07D491/048 , C07D487/04 , A61K31/4355 , A61K31/4365 , C07D471/04 , C07D491/04 , C07D495/04 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US20200283403A1
公开(公告)日：2020-09-10
申请号：US16824885
申请日：2020-03-20
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号： C07D401/12 , C07C317/42 , C07D213/54 , C07D213/74 , C07D213/75 , C07D213/81 , C07D213/84 , C07D471/04 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D213/40
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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公开(公告)号：US20190105307A1
公开(公告)日：2019-04-11
申请号：US16212360
申请日：2018-12-06
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4355 , A61K31/496 , A61K31/4365 , A61K31/437 , A61K31/497 , A61K31/519 , C07D471/04 , A61K31/55 , C07D487/04 , C07D491/048 , A61K45/06 , C07D495/04 , C07D491/04 , A61K31/5377
CPC分类号： A61K31/4355 , A61K31/4365 , A61K31/437 , A61K31/496 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US20190388405A1
公开(公告)日：2019-12-26
申请号：US16538208
申请日：2019-08-12
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Peter Dragovich , Francis Gosselin , Bingsong Han , Jian Lin , Dominic J. Reynolds , Bruce Roth , Chase C. Smith , Zhongguo Wang , Po-Wai Yuen , Xiaozhang Zheng
IPC分类号： A61K31/4355 , C07D491/048 , C07D487/04 , A61K45/06 , A61K31/55 , A61K31/5377 , A61K31/519 , A61K31/497 , A61K31/496 , A61K31/437 , A61K31/4365 , C07D495/04 , C07D491/04 , C07D471/04
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US10329275B2
公开(公告)日：2019-06-25
申请号：US16008378
申请日：2018-06-14
申请人： Forma TM, LLC , Genentech, Inc.
发明人： Kenneth W. Bair , Timm R. Baumeister , Alexandre J. Buckmelter , Karl H. Clodfelter , Bingsong Han , Jian Lin , Dominic J. Reynolds , Chase C. Smith , Zhongguo Wang , Xiaozhang Zheng , Po-Wai Yuen
IPC分类号： C07D401/12 , C07D471/04 , C07D213/54 , C07D213/75 , C07D213/81 , C07C317/42 , C07D213/74 , C07D213/84 , A61K31/437 , A61K31/44 , A61K31/4406 , A61K31/4545 , A61K31/5377 , A61K45/06 , C07D213/40
摘要： The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
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