公开(公告)号：US06525226B2

公开(公告)日：2003-02-25

申请号：US10187183

申请日：2002-07-01

申请人： Vasant Ram chandra Choudhary ,  Suman Kumar Jana

发明人： Vasant Ram chandra Choudhary ,  Suman Kumar Jana

IPC分类号： C07C4530

CPC分类号： C07C41/30 ,  C07C2/861 ,  C07C2/864 ,  C07C45/46 ,  C07C201/12 ,  C07C2521/10 ,  C07C2523/08 ,  C07C2527/236 ,  C07C2603/24 ,  C07C15/16 ,  C07C49/784 ,  C07C49/83 ,  C07C49/84 ,  C07C49/786 ,  C07C205/06 ,  C07C15/12 ,  C07C15/28 ,  C07C43/205

摘要： A process for Friedel-Crafts type liquid-phase alkylation or acylation of an aromatic compound using a hydrotalcite-type basic anionic clay catalyst represented by a formula: [(M2+)1−x(M3+)x(OH)2]x+[Ay−]x/y q H2O where M2+ is a divalent cation selected from Mg2+, Zn2+, Ni2+, Co2+, Mn2+, Cu2+ or a mixture thereof, M3+ is a trivalent cation selected from Ga3+, In3+ Al3+, Fe3+ Cr3+ or a mixture thereof; x is a mole fraction of trivalent cations in the range of about 0.05 to about 0.5; O is oxygen; H is hydrogen; Ay− is an anion; y minus is an anionic negative charge having a value of 1 minus or 2 minus; and q is a number of water molecules, as the water of hydration; and involving following steps: i. pretreating said catalyst by contacting it with a halogen containing compound in the presence or absence of a non-aqueous solvent and optionally washing the pretreated catalyst with non-aqueous solvent or liquid aromatic compound to be alkylated or acylated; and then ii. contacting a liquid reaction mixture comprising said aromatic compound and said alkylating or acylating agent in the presence or absence of a non-aqueous solvent with the catalyst obtained from step (i) in a stirred batch reactor fitted with a reflux condenser under vigorous stirring, in the presence or absence of an inert gas bubbling through the reaction mixture, at effective reaction conditions; iii. cooling the reaction mixture to a temperature about 30° C., removing said catalyst from the reaction mixture by filtration and then separating the reaction products from the reaction mixture, and optionally washing the used catalyst by non-aqueous solvent; and if desired, iv. reusing the used catalyst directly with or without drying for the subsequent reaction batch avoiding step (i), is disclosed.

摘要翻译： 使用由下式表示的水滑石型碱性阴离子粘土催化剂，使用Friedel-Crafts型液相烷基化或芳族化合物酰化的方法：其中M2 +是选自Mg2 ​​+，Zn2 +，Ni2 +，Co2 +，Mn2 +，Cu2 +或 其混合物，M3 +是选自Ga3 +，In3 + Al3 +，Fe3 + Cr3 +或其混合物的三价阳离子; x是三价阳离子在约0.05至约0.5范围内的摩尔分数; O是氧; H是氢; Ay-是阴离子; y minus是具有值1或2减去的阴离子负电荷; 和q是水分子的数量，作为水合水; 并涉及以下步骤：i。 在存在或不存在非水溶剂的情况下，通过使其与含卤素的化合物接触来预处理所述催化剂，并任选地用待进行烷基化或酰化的非水溶剂或液体芳族化合物洗涤预处理的催化剂; 然后。 在非水溶剂存在或不存在下，将含有所述芳族化合物和所述烷基化或酰化剂的液体反应混合物与步骤（i）获得的催化剂在剧烈搅拌下在装有回流冷凝器的搅拌间歇式反应器中接触， 在有效的反应条件下存在或不存在通过反应混合物鼓泡的惰性气体; iii。 将反应混合物冷却至约30℃的温度，通过过滤从反应混合物中除去所述催化剂，然后将反应产物与反应混合物分离，并任选地通过非水溶剂洗涤所用催化剂; 如果需要，iv。 公开了直接使用或不用干燥后续反应批次的用过的催化剂，以避免步骤（i）。