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1.发明授权Method for generating immune responses utilizing nucleic acids encoding fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutralization epitopes 失效使用编码融合蛋白的核酸产生免疫应答的方法，其包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和侵袭素多肽公开(公告)号：US08568734B2
公开(公告)日：2013-10-29
申请号：US13426295
申请日：2012-03-21
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W Barnett , Indresh K. Srivastava , Rino Rappuoli
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
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2.发明申请公开(公告)号：US20100183653A1
公开(公告)日：2010-07-22
申请号：US11597340
申请日：2005-06-08
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
IPC分类号： A61K39/02 , A61K39/21 , C12P21/06 , C12N5/10 , C12N1/21 , C12N1/19 , C12N15/63 , C07K14/24 , C07K16/00 , C07H21/04 , C07K14/155
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
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3.发明授权Fusion proteins comprising CD4 minimal modules and invasin polypeptides that are capable of binding to the HIV envelope and exposing cryptic neutraliziation epitopes 有权包含能够结合HIV包膜并暴露神经中和表位的CD4最小模块和侵袭素多肽的融合蛋白公开(公告)号：US08206720B2
公开(公告)日：2012-06-26
申请号：US11597340
申请日：2005-06-08
申请人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
发明人： Vega Masignani , Maria Scarselli , Barbara Capecchi , Victoria Sharma , Susan W. Barnett , Indresh K. Srivastava , Rino Rappuoli
CPC分类号： C07K14/70514 , C07K2319/01
摘要： Fusion proteins comprising CD4 minimal modules that bind to HIV Env polypeptides in a non-CD4 backbone are described. Also described are complexes of these fusion proteins with Env as well as methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
摘要翻译： 描述了包含在非CD4主链中结合HIV Env多肽的CD4最小模块的融合蛋白。 还描述了这些融合蛋白与Env的复合物以及使用多核苷酸和多肽的诊断，治疗和预防的方法。
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公开(公告)号：US20120276141A1
公开(公告)日：2012-11-01
申请号：US13492219
申请日：2012-06-08
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/541 , A61K2039/57 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C12N2740/16134 , G01N2333/162 , G01N2333/70514 , G01N2500/02
摘要： Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration.
摘要翻译： 本文提供有效结合HIV Env蛋白的小分子CD4模拟物。 当与Env蛋白结合时，本发明的CD4模拟物可有效诱导Env蛋白质的构象变化，从而暴露Env蛋白质上的细胞表位。 本文还提供了鉴定和使用这种小分子CD4模拟物的相关方法，例如在给药时在受试者中引发免疫应答。
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公开(公告)号：US08197819B2
公开(公告)日：2012-06-12
申请号：US11597337
申请日：2005-06-08
IPC分类号： A61K39/21 , A61K39/00 , C07D207/00 , C07D487/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/541 , A61K2039/57 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C12N2740/16134 , G01N2333/162 , G01N2333/70514 , G01N2500/02
摘要： Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration.
摘要翻译： 本文提供有效结合HIV Env蛋白的小分子CD4模拟物。 当与Env蛋白结合时，本发明的CD4模拟物可有效诱导Env蛋白质的构象变化，从而暴露Env蛋白质上的细胞表位。 本文还提供了鉴定和使用这种小分子CD4模拟物的相关方法，例如在给药时在受试者中引发免疫应答。
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公开(公告)号：US20080300385A1
公开(公告)日：2008-12-04
申请号：US11729076
申请日：2007-03-27
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/62 , A61K2039/64 , C12N2740/16122 , C12N2740/16134 , C12N2740/16322 , C12N2740/16334
摘要： Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is important to the binding properties of the complexes, and so is controlled to avoid the loss of Env's ability to bind specifically to CD4 and Tat's ability to bind specifically to anti-Tat monoclonal antibodies.
摘要翻译： HIV环境和Tat蛋白的复合物作为免疫原与Tat或Env单独相比是有利的，但当与疫苗佐剂组合时它们可能解离。 为了避免解离，Env和Tat的复合物通过使用共价交联来稳定。 交联的程度对于复合物的结合特性是重要的，因此被控制以避免Env特异性结合CD4和Tat特异性结合抗Tat单克隆抗体的能力的丧失。
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公开(公告)号：US20080199492A1
公开(公告)日：2008-08-21
申请号：US11597337
申请日：2005-06-08
IPC分类号： A61K39/00 , G01N33/566 , C40B30/04 , A61P37/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/541 , A61K2039/57 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C12N2740/16134 , G01N2333/162 , G01N2333/70514 , G01N2500/02
摘要： Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration.
摘要翻译： 本文提供有效结合HIV Env蛋白的小分子CD4模拟物。 当与Env蛋白结合时，本发明的CD4模拟物可有效诱导Env蛋白质的构象变化，从而暴露Env蛋白质上的细胞表位。 本文还提供了鉴定和使用这种小分子CD4模拟物的相关方法，例如在给药时在受试者中引发免疫应答。
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