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公开(公告)号：US20120276141A1
公开(公告)日：2012-11-01
申请号：US13492219
申请日：2012-06-08
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/541 , A61K2039/57 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C12N2740/16134 , G01N2333/162 , G01N2333/70514 , G01N2500/02
摘要： Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration.
摘要翻译： 本文提供有效结合HIV Env蛋白的小分子CD4模拟物。 当与Env蛋白结合时，本发明的CD4模拟物可有效诱导Env蛋白质的构象变化，从而暴露Env蛋白质上的细胞表位。 本文还提供了鉴定和使用这种小分子CD4模拟物的相关方法，例如在给药时在受试者中引发免疫应答。
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2.发明授权Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides, and uses thereof 有权编码抗原性HIV B型多肽的多核苷酸，多肽及其用途公开(公告)号：US08263394B2
公开(公告)日：2012-09-11
申请号：US12018413
申请日：2008-01-23
申请人： Jan zur Megede , Susan W. Barnett
发明人： Jan zur Megede , Susan W. Barnett
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/86 , C12N2740/16022 , C12N2740/16043 , C12N2740/16052 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2800/108 , C12N2830/42 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.
摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了在包括免疫，产生包装细胞系以及产生HIV多肽的应用中多核苷酸的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及来自其的这些多核苷酸和多肽产物的用途，包括免疫原性组合物的制剂及其用途。
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公开(公告)号：US08197819B2
公开(公告)日：2012-06-12
申请号：US11597337
申请日：2005-06-08
IPC分类号： A61K39/21 , A61K39/00 , C07D207/00 , C07D487/00
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/541 , A61K2039/57 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C12N2740/16134 , G01N2333/162 , G01N2333/70514 , G01N2500/02
摘要： Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration.
摘要翻译： 本文提供有效结合HIV Env蛋白的小分子CD4模拟物。 当与Env蛋白结合时，本发明的CD4模拟物可有效诱导Env蛋白质的构象变化，从而暴露Env蛋白质上的细胞表位。 本文还提供了鉴定和使用这种小分子CD4模拟物的相关方法，例如在给药时在受试者中引发免疫应答。
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公开(公告)号：US20100015211A1
公开(公告)日：2010-01-21
申请号：US11664962
申请日：2005-11-01
IPC分类号： A61K9/127 , A61K39/21 , A61K39/295 , A61K39/116 , A61K39/00 , A61P37/04 , A61P31/12 , A61P31/18
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C12N2710/10343 , C12N2740/16122 , C12N2760/16134
摘要： The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.
摘要翻译： 本发明涉及编码来自HIV亚型和/或不同亚型中的相同或不同菌株的免疫原性相同或类似的HIV多肽的方法，多肽和多核苷酸。 还描述了用于产生免疫应答的组合方法中多核苷酸和多肽的用途。 本文描述的组合方法诱导针对来自给定亚型中的多种菌株和针对不同亚型的多种HIV株的广泛和有效的免疫应答。 还公开了用于产生免疫应答的组合物的制剂和用于这种组合物的方法。
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公开(公告)号：US06602705B1
公开(公告)日：2003-08-05
申请号：US09475515
申请日：1999-12-30
申请人： Susan W. Barnett , Jan zur Megede , Catherine Greer , Mark Selby
发明人： Susan W. Barnett , Jan zur Megede , Catherine Greer , Mark Selby
IPC分类号： C12N1500
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.
摘要翻译： 本发明涉及HIV多肽在各种细胞类型中的有效表达，包括但不限于哺乳动物，昆虫和植物细胞。 描述了编码含有HIV Gag的多肽的合成表达盒，以及包括DNA免疫，产生包装细胞系以及产生含有Env，tat或Gag的蛋白质的应用中的表达盒的用途。 本发明提供了生产病毒样颗粒（VLP）的方法，以及VLP的使用，包括但不限于用于呈递抗体的媒介物和在施用VLP的受试者中刺激免疫应答。
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公开(公告)号：US08609109B2
公开(公告)日：2013-12-17
申请号：US13334739
申请日：2011-12-22
申请人： John Donnelly , Susan W. Barnett , Derek O'Hagan
发明人： John Donnelly , Susan W. Barnett , Derek O'Hagan
CPC分类号： A61K39/21 , A61K39/12 , A61K48/0041 , A61K48/005 , A61K48/0083 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/57 , A61K2039/6093 , C07K14/005 , C12N15/87 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234
摘要： Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject.
摘要翻译： 本文提供包含吸附于PLG和/或HIV蛋白质的编码HIV多肽的DNA的HIV疫苗。 还提供了使用这些疫苗在受试者中产生免疫应答的方法。
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7.发明授权公开(公告)号：US08541230B2
公开(公告)日：2013-09-24
申请号：US13108900
申请日：2011-05-16
申请人： Susan W. Barnett , Jan Zur Megede
发明人： Susan W. Barnett , Jan Zur Megede
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Gag- and/or Env-containing proteins are also described.
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8.发明授权Method of inducing an antiviral immune response against HIV-1 utilizing chimeric HIV Env proteins comprising CD4 mini-proteins or CD4 mimetics 有权使用包含CD4微型蛋白或CD4模拟物的嵌合HIV Env蛋白诱导针对HIV-1的抗病毒免疫应答的方法公开(公告)号：US08470334B2
公开(公告)日：2013-06-25
申请号：US13544063
申请日：2012-07-09
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/6031 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/76 , C07K2319/32 , C12N2740/10043 , C12N2740/16122 , C12N2740/16134 , C12N2770/36143 , C12N2800/107
摘要： Env-CD4 polypeptide complexes and hybrids that expose cryptic epitopes important in virus neutralization are disclosed. Methods of diagnosis, treatment and prevention using the polypeptides are also provided.
摘要翻译： 公开了暴露在病毒中和中重要的隐蔽表位的Env-CD4多肽复合物和杂交体。 还提供了使用多肽进行诊断，治疗和预防的方法。
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9.发明授权Chimeric HIV Env proteins comprising CD4 mini-proteins or CD4 mimetics that are capable of inducing neutralizing antibody responses against cryptic Env epitopes 有权包含能够诱导针对隐性Env表位的中和抗体应答的CD4微型蛋白或CD4模拟物的嵌合HIV Env蛋白公开(公告)号：US08226955B2
公开(公告)日：2012-07-24
申请号：US12859356
申请日：2010-08-19
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/545 , A61K2039/55566 , A61K2039/6031 , C07K14/70514 , C07K16/1063 , C07K16/2812 , C07K2317/32 , C07K2317/76 , C07K2319/32 , C12N2740/10043 , C12N2740/16122 , C12N2740/16134 , C12N2770/36143 , C12N2800/107
摘要： Env-CD4 polypeptide complexes and hybrids that expose cryptic epitopes important in virus neutralization are disclosed. Method of diagnosis, treatment and prevention using the polypeptides are also provided.
摘要翻译： 公开了暴露在病毒中和中重要的隐蔽表位的Env-CD4多肽复合物和杂交体。 还提供了使用多肽进行诊断，治疗和预防的方法。
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10.发明授权Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof 失效编码抗原性HIV C型多肽的多核苷酸，多肽及其用途公开(公告)号：US07943375B2
公开(公告)日：2011-05-17
申请号：US12215189
申请日：2008-06-25
申请人： Susan W. Barnett , Jan zur Megede
发明人： Susan W. Barnett , Jan zur Megede
CPC分类号： C12N7/00 , A61K39/00 , A61K48/00 , A61K2039/5156 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N15/86 , C12N2740/16023 , C12N2740/16052 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222 , C12N2800/108 , C12N2840/203
摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C Gag- and/or Env-containing polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell lines, and production of Gag- and/or Env-containing proteins are also described.
摘要翻译： 本发明涉及编码免疫原性HIV C型Gag-和/或含Env的多肽的多核苷酸。 还描述了多核苷酸在包括DNA免疫，产生包装细胞系以及产生含Gag和/或含Env的蛋白质的应用中的用途。
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