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公开(公告)号：US07067550B2
公开(公告)日：2006-06-27
申请号：US10143534
申请日：2002-05-10
IPC分类号： A61K31/4035
CPC分类号： G01N33/5008 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/192 , A61K31/225 , A61K31/277 , A61K31/40 , A61K31/4035 , A61K31/475 , A61K31/485 , A61K31/55 , G01N33/502 , G01N33/5058 , G01N33/6896 , G01N2500/10 , G01N2800/2821
摘要： The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can reduce the neurotoxic effects of such aggregates. Methods for treating conditions resulting from neurotoxic β-amyloid peptide aggregates, such as Alzheimer's disease and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can reduce the neurotoxic effects of β-amyloid aggregates.
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公开(公告)号：US07101879B2
公开(公告)日：2006-09-05
申请号：US10051663
申请日：2002-01-18
IPC分类号： A61S31/535
CPC分类号： G01N33/5058 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/192 , A61K31/225 , A61K31/277 , A61K31/40 , A61K31/475 , A61K31/485 , A61K31/55 , G01N33/5008 , G01N33/502 , G01N33/6872 , G01N33/6896 , G01N2500/10 , G01N2800/2821
摘要： The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can reduce the neurotoxic effects of such aggregates. Methods for treating conditions resulting from neurotoxic β-amyloid peptide aggregates, such as Alzheimer's disease and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can reduce the neurotoxic effects of β-amyloid aggregates.
摘要翻译： 本发明涉及鉴定β-淀粉样蛋白肽细胞毒性的机制，其能够通过施用拮抗细胞毒性机制的化合物来治疗由β-淀粉样肽聚集体引起的病症。 本发明包括鉴定和分离可降低这种聚集体的神经毒性作用的化合物。 提供了用于治疗由神经毒性β-淀粉样肽聚集体（例如阿尔茨海默病）和药物制剂产生的病症的方法。 还提供了用于选择可以降低β-淀粉样蛋白聚集体的神经毒性作用的其它化合物的方法。
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3.发明授权Methods for identifying treatments for neurotoxicity in Alzheimer's disease caused by β-amyloid peptides 失效用于鉴定由β-淀粉样蛋白肽引起的阿尔茨海默病神经毒性治疗方法公开(公告)号：US06942963B1
公开(公告)日：2005-09-13
申请号：US09706574
申请日：2000-11-03
CPC分类号： C07K7/06 , A61K38/08 , C07K1/047 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S435/808 , Y10S436/80 , Y10S436/805
摘要： The invention involves identification of a mechanism of β-amyloid peptide cytotoxicity, which enables treatment of conditions caused by β-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can antagonize the aggregation of β-amyloid peptides and the neurotoxic effects of such aggregates. The compounds include isolated peptides which were selected for their ability to form a complex with a β-amyloid peptide, or are derived from peptides so selected. Methods for treating conditions resulting from neurotoxic β-amyloid peptide aggregates and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can antagonize the aggregation of β-amyloid peptides and the neurotoxic effects of such aggregates.
摘要翻译： 本发明涉及鉴定β-淀粉样蛋白肽细胞毒性的机制，其能够通过施用拮抗细胞毒性机制的化合物来治疗由β-淀粉样肽聚集体引起的病症。 本发明包括鉴定和分离可以拮抗β-淀粉样蛋白肽聚集的化合物和这些聚集体的神经毒性作用。 化合物包括被选择为与β-淀粉样肽形成复合物的能力的分离的肽，或者衍生自如此选择的肽。 提供了用于治疗由神经毒性β-淀粉样肽聚集体和药物制剂产生的病症的方法。 还提供了用于选择可以拮抗β-淀粉样肽聚集的其它化合物的方法和这些聚集体的神经毒性作用。
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4.发明授权Treatments for neurotoxicity in Alzheimer's disease caused by &bgr; amyloid peptides 失效由β淀粉样蛋白肽引起的阿尔茨海默病神经毒性的治疗公开(公告)号：US06172043B2
公开(公告)日：2001-01-09
申请号：US09005215
申请日：1998-01-09
IPC分类号： A61K3804
CPC分类号： C07K7/06 , A61K38/08 , C07K1/047 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： The invention involves identification of a mechanism of &bgr;-amyloid peptide cytotoxicity, which enables treatment of conditions caused by &bgr;-amyloid peptide aggregates by administration of compounds which antagonize the mechanism of cytotoxicity. The invention includes the identification and isolation of compounds which can antagonize the aggregation of &bgr;-amyloid peptides and the neurotoxic effects of such aggregates. The compounds include isolated peptides which were selected for their ability to form a complex with a &bgr;-amyloid peptide, or are derived from peptides so selected. Methods for treating conditions resulting from neurotoxic &bgr;-amyloid peptide aggregates and pharmaceutical preparations are provided. Also provided are methods for selecting additional compounds which can antagonize the aggregation of &bgr;-amyloid peptides and the neurotoxic effects of such aggregates.
摘要翻译： 本发明涉及鉴定β-淀粉样蛋白肽细胞毒性的机制，其能够通过施用拮抗细胞毒性机制的化合物来治疗由β-淀粉样肽聚集体引起的病症。 本发明包括鉴定和分离可以拮抗β-淀粉样蛋白肽聚集的化合物和这些聚集体的神经毒性作用。 化合物包括被选择为与β-淀粉样肽形成复合物的能力的分离的肽，或者衍生自如此选择的肽。 提供了用于治疗由神经毒性β-淀粉样肽聚集体和药物制剂产生的病症的方法。 还提供了用于选择可以拮抗β-淀粉样肽聚集的其它化合物的方法和这些聚集体的神经毒性作用。
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