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    MULTICOMPARTMENT MACROENCAPSULATION DEVICES
    5.
    发明申请
    MULTICOMPARTMENT MACROENCAPSULATION DEVICES 有权

    公开(公告)号：US20220143374A1

    公开(公告)日：2022-05-12

    申请号：US17600672

    申请日：2020-04-02

    申请人： Vertex Pharmaceuticals Incorporated

    发明人： Christopher Thanos ,  John Mills ,  Megan Billings

    IPC分类号： A61M31/00 ,  B01D69/12 ,  B01D69/02

    摘要： Macroencapsulation devices and their methods of use are disclosed. In one embodiment, a macroencapsulation device may include a first outer membrane, a second outer membrane, and at least one semipermeable membrane disposed there between to form at least a primary compartment configured to house a first population of cells and a secondary compartment in fluid communication with the primary compartment through the first semipermeable membrane. In some embodiments, the flow of material into and out of the compartments of the macroencapsulation device and/or the application of an appropriate pressure differential between the compartments may be used to control the flow of filtrates, ancillary agents, and other materials between the compartments of the device when positioned in vivo.

    MACROENCAPSULATION DEVICES
    6.
    发明公开
    MACROENCAPSULATION DEVICES 审中-公开

    公开(公告)号：US20240352392A1

    公开(公告)日：2024-10-24

    申请号：US18682738

    申请日：2022-08-16

    申请人： Vertex Pharmaceuticals Incorporated

    发明人： Christopher Thanos ,  John Mills ,  Matthew Watson ,  Rahul R. Rajendran ,  Noah Nguyen

    IPC分类号： C12M1/12

    CPC分类号： C12M25/16 ,  C12M25/02

    摘要： Macroencapsulation devices and related methods of manufacture are described where bonded membranes of a device may be mounted to an associated frame in an arrangement to provide stress relief between the frame and a seal perimeter of the bonded membranes. The seal perimeter may be arranged radially inward from an outer perimeter of the membranes such that when the membranes are mounted to a corresponding perimeter frame, the seal perimeter is spaced radially inwards from the frame with a unbonded portion of the one or more membranes disposed between the frame and seal perimeter.