公开(公告)号：US20130338188A9

公开(公告)日：2013-12-19

申请号：US13657321

申请日：2012-10-22

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： Fredrick F. Van Goor ,  Rossitza Gueorguieva Alargova ,  Tim Edward Alcacio ,  Sneha G. Arekar ,  Steven C. Johnston ,  Irina Nikolaevna Kadiyala ,  Ali Keshavarz-Shokri ,  Mariusz Krawiec ,  Elaine Chungmin Lee ,  Ales Medek ,  Praveen Mudunuri ,  Mark Jeffrey Sullivan ,  Noreen Tasneem Zaman ,  Beili Zhang ,  Yuegang Zhang ,  Gregor Zlokarnik

IPC分类号： A61K31/47 ,  A61P11/00 ,  A61P1/18 ,  C12Q1/02 ,  A61P3/10 ,  A61P35/00 ,  A61P25/28 ,  A61P25/16 ,  A61P11/06 ,  A61P1/16

CPC分类号： A61K31/47 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4704 ,  G01N33/5032 ,  G01N2500/04 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：US20130079367A1

公开(公告)日：2013-03-28

申请号：US13682075

申请日：2012-11-20

申请人： Vertex Pharmaceuticals Incorporated

发明人： Sneha G. Arekar ,  Steven C. Johnston ,  Mariusz Krawiec ,  Ales Medek ,  Praveen Mudunuri ,  Mark Jeffrey Sullivan

IPC分类号： C07D215/56

CPC分类号： C07D215/56

摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

摘要翻译： 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。

公开(公告)号：US20140329855A1

公开(公告)日：2014-11-06

申请号：US14334902

申请日：2014-07-18

申请人： Vertex Pharmaceuticals Incorporated

发明人： Sneha G. Arekar ,  Steven C. Johnston ,  Mariusz Krawiec ,  Ales Medek ,  Praveen Mudunuri ,  Mark Jeffrey Sullivan

IPC分类号： C07D215/56

CPC分类号： C07D215/56

摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

摘要翻译： 本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物 及其方法。

公开(公告)号：US20130018071A1

公开(公告)日：2013-01-17

申请号：US13622598

申请日：2012-09-19

申请人： Vertex Pharmaceuticals Incorporated

发明人： Sneha G. Arekar ,  Steven C. Johnston ,  Mariusz Krawiec ,  Ales Medek ,  Praveen Mudunuri ,  Mark Jeffrey Sullivan

IPC分类号： C07D215/56 ,  A61P11/06 ,  A61P11/00 ,  A61P29/00 ,  A61P1/00 ,  A61P1/16 ,  A61P1/10 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P7/12 ,  A61P27/02 ,  A61P19/10 ,  A61P19/08 ,  A61P25/00 ,  A61P25/28 ,  A61P25/16 ,  A61P25/14 ,  A61K31/47

CPC分类号： C07D215/56

摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

公开(公告)号：US08785476B2

公开(公告)日：2014-07-22

申请号：US13682075

申请日：2012-11-20

申请人： Vertex Pharmaceuticals Incorporated

发明人： Sneha G. Arekar ,  Steven C. Johnston ,  Mariusz Krawiec ,  Ales Medek ,  Praveen Mudunuri ,  Mark Jeffrey Sullivan

IPC分类号： C07D215/56

CPC分类号： C07D215/56

摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.

公开(公告)号：US20130143919A1

公开(公告)日：2013-06-06

申请号：US13657321

申请日：2012-10-22

申请人： Vertex Pharmaceuticals Incorporated

发明人： Fredrick F. Van Goor ,  Rossitza Gueorguieva Alargova ,  Tim Edward Alcacio ,  Sneha G. Arekar ,  Steven C. Johnston ,  Irina Nikolaevna Kadiyala ,  Ali Keshavarz-Shokri ,  Mariusz Krawiec ,  Elaine Chungmin Lee ,  Ales Medek ,  Praveen Mudunuri ,  Mark Jeffrey Sullivan ,  Noreen Tasneem Zaman ,  Beili Zhang ,  Yuegang Zhang ,  Gregor Zlokarnik

IPC分类号： A61K31/47 ,  A61P11/00 ,  A61P1/18 ,  C12Q1/02 ,  A61P3/10 ,  A61P35/00 ,  A61P25/28 ,  A61P25/16 ,  A61P11/06 ,  A61P1/16

CPC分类号： A61K31/47 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4704 ,  G01N33/5032 ,  G01N2500/04 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：US20190038615A1

公开(公告)日：2019-02-07

申请号：US15898683

申请日：2018-02-19

申请人： Vertex Pharmaceuticals Incorporated

发明人： Fredrick F. Van Goor ,  Rossitza Gueorguieva Alargova ,  Tim Edward Alcacio ,  Sneha G. Arekar ,  Steven C. Johnston ,  Irina Nicolaevna Kadiyala ,  Ali Keshavarz-Shokri ,  Mariusz Krawiec ,  Elaine Chungmin Lee ,  Ales Medek ,  Praveen Mudunuri ,  Mark Jeffrey Sullivan ,  Noreen Tasneem Zaman ,  Beili Zhang ,  Yuegang Zhang ,  Gregor Zlokarnik

IPC分类号： A61K31/47 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4704 ,  A61K31/404 ,  G01N33/50

摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：US20160067239A9

公开(公告)日：2016-03-10

申请号：US14603779

申请日：2015-01-23

申请人： Vertex Pharmaceuticals Incorporated

发明人： Fredrick F. Van Goor ,  Rossitza Gueorguieva Alargova ,  Tim Edward Alcacio ,  Sneha G. Arekar ,  Steven C. Johnston ,  Irina Nikolaevna Kadiyala ,  Ali Keshavarz-Shokri ,  Mariusz Krawiec ,  Elaine Chungmin Lee ,  Ales Medek ,  Praveen Mudunuri ,  Mark Jeffrey Sullivan ,  Noreen Tasneem Zaman ,  Beili Zhang ,  Yuegang Zhang ,  Gregor Zlokarnik

IPC分类号： A61K31/47 ,  A61K31/404 ,  G01N33/50 ,  A61K31/443

CPC分类号： A61K31/47 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4704 ,  G01N33/5032 ,  G01N2500/04 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

公开(公告)号：US20160022665A2

公开(公告)日：2016-01-28

申请号：US14630778

申请日：2015-02-25

申请人： Vertex Pharmaceuticals Incorporated

发明人： Fredrick F. Van Goor ,  Rossitza Gueorguieva Alargova ,  Tim Edward Alcacio ,  Sneha G. Arekar ,  Hayley Marie Binch ,  Martyn Curtis Botfield ,  Lev Tyler Dewey Fanning ,  Peter Diederik Jan Grootenhuis ,  Dennis James Hurley ,  Steven C. Johnston ,  Irina Nikolaevna Kadiyala ,  Ritu Rohit Kaushik ,  Ali Keshavarz-Shokri ,  Mariusz Krawiec ,  Elaine Chungmin Lee ,  Brian Luisi ,  Ales Medek ,  Praveen Mudunuri ,  Mehdi Numa ,  Urvi Jagdishbhai Sheth ,  Alina Silina ,  Mark Jeffrey Sullivan ,  Marinus Jacobus Verwijs ,  Xiaoqing Yang ,  Christopher Ryan Young ,  Noreen Tasneem Zaman ,  Beili Zhang ,  Yuegang Zhang ,  Gregor Zlokarnik

IPC分类号： A61K31/4709 ,  G01N33/68 ,  A61K31/404 ,  A61K31/47 ,  A61K31/443

CPC分类号： A61K31/4709 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/4704 ,  G01N33/6872 ,  G01N2333/4703 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.

摘要翻译： 本发明涉及包含式I和II化合物，任选与式III化合物和/或式IV化合物组合的药物组合物。 本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。

公开(公告)号：US20130131107A1

公开(公告)日：2013-05-23

申请号：US13657345

申请日：2012-10-22

申请人： Vertex Pharmaceuticals Incorporated

发明人： Fredrick F. Van Goor ,  Rossitza Gueorguieva Alargova ,  Tim Edward Alcacio ,  Sneha G. Arekar ,  Hayley Marie Binch ,  Martyn Curtis Botfield ,  Lev Tyler Dewey Fanning ,  Peter Diederik Jan Grootenhuis ,  Dennis James Hurley ,  Steven C. Johnston ,  Irina Nikolaevna Kadiyala ,  Ritu Rohit Kaushik ,  Ali Keshavarz-Shokri ,  Mariusz Krawiec ,  Elaine Chungmin Lee ,  Brian Luisi ,  Ales Medek ,  Praveen Mudunuri ,  Mehdi Numa ,  Urvi Jagdishbhai Sheth ,  Alina Silina ,  Mark Jeffrey Sullivan ,  Marinus Jacobus Verwijs ,  Xiaoqing Yang ,  Christopher Ryan Young ,  Noreen Tasneem Zaman ,  Beili Zhang ,  Yuegang Zhang ,  Gregor Zlokarnik

IPC分类号： A61K31/47 ,  A61K31/404 ,  A61K31/443

CPC分类号： A61K31/4709 ,  A61K31/404 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/47 ,  A61K31/4704 ,  G01N33/6872 ,  G01N2333/4703 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.