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公开(公告)号：US5268181A
公开(公告)日：1993-12-07
申请号：US905785
申请日：1992-06-29
IPC分类号： A61K9/22 , A61K9/20 , A61K31/455 , A61K47/38 , A61K9/30
CPC分类号： A61K9/2013 , A61K31/455 , A61K9/2054 , Y10S514/824
摘要： The invention provides a therapeutic method to treat hyperlipidemia by administering to a human patient a single daily dose of a prolonged release dosage form of niacin, so that nocturnal cholesterol synthesis is effectively suppressed.
摘要翻译： 本发明提供了一种治疗高脂血症的治疗方法，其通过向人类患者施用单次日剂量的烟酸延长释放剂型，从而有效抑制夜间胆固醇合成。
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公开(公告)号：US08013017B2
公开(公告)日：2011-09-06
申请号：US12479524
申请日：2009-06-05
CPC分类号： A61K31/573 , A61K8/31 , A61K8/345 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/49 , A61K8/73 , A61K9/0014 , A61K31/19 , A61K31/535 , A61K31/5375 , A61K31/56 , A61K45/06 , A61K47/44 , A61K2800/524 , A61Q19/00 , A61Q19/007 , A61K2300/00
摘要： Dermatological compositions (methods of making and using) that include one or more anesthetic agents and/or one or more anti-inflammatory agents and/or a combination of ammonium, sodium, and potassium salts, preferably of an alpha-hydroxy acid.
摘要翻译： 皮肤病学组合物（制备和使用方法）包括一种或多种麻醉剂和/或一种或多种抗炎剂和/或铵，钠和钾盐，优选α-羟基酸的组合。
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公开(公告)号：US20090247632A1
公开(公告)日：2009-10-01
申请号：US12479524
申请日：2009-06-05
CPC分类号： A61K31/573 , A61K8/31 , A61K8/345 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/49 , A61K8/73 , A61K9/0014 , A61K31/19 , A61K31/535 , A61K31/5375 , A61K31/56 , A61K45/06 , A61K47/44 , A61K2800/524 , A61Q19/00 , A61Q19/007 , A61K2300/00
摘要： Dermatological compositions (methods of making and using) that include one or more anesthetic agents and/or one or more anti-inflammatory agents and/or a combination of ammonium, sodium, and potassium salts, preferably of an alpha-hydroxy acid.
摘要翻译： 皮肤病学组合物（制备和使用方法）包括一种或多种麻醉剂和/或一种或多种抗炎剂和/或铵，钠和钾盐，优选α-羟基酸的组合。
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公开(公告)号：US5462740A
公开(公告)日：1995-10-31
申请号：US122685
申请日：1993-09-17
CPC分类号： A61M3/02 , A61K9/0031 , A61M5/24 , A61M2005/311 , A61M5/502 , Y10S424/15 , Y10S514/964
摘要： This invention provides a rectally administered composition for inhibiting epileptic seizure and to its methods of use. The composition contains, in a suitable solvent, an anti-epileptic agent for inhibiting epileptic seizure, a buffer for maintaining pH, and a thickener for imparting a viscosity to the composition effective for rectal administration by injection to a patient in epileptic seizure.
摘要翻译： 本发明提供了用于抑制癫痫发作的直肠给药组合物及其使用方法。 该组合物在合适的溶剂中含有用于抑制癫痫发作的抗癫痫剂，用于维持pH的缓冲液，和增稠剂，用于通过注射给患者癫痫发作给予直肠给药有效的组合物的粘度。
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公开(公告)号：US5126145A
公开(公告)日：1992-06-30
申请号：US536184
申请日：1990-06-11
IPC分类号： A61K9/22 , A61K9/20 , A61K31/455 , A61K47/38
CPC分类号： A61K31/455 , A61K9/2013 , A61K9/2054 , Y10S514/96 , Y10S514/964
摘要： A sustained or controlled release tablet is disclosed. The tablet comprises a water soluble medicament, a hydroxypropyl methylcellulose having sustaining action, a pharmaceutical binding agent, and a hydrophobic component.
摘要翻译： 公开了持续或控释片剂。 片剂包含水溶性药物，具有维持作用的羟丙基甲基纤维素，药物结合剂和疏水组分。
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公开(公告)号：US08362029B2
公开(公告)日：2013-01-29
申请号：US13142784
申请日：2009-12-31
申请人： Kenneth L. Evenstad , Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Stephen M. Berge
发明人： Kenneth L. Evenstad , Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Stephen M. Berge
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/10 , A61K31/135 , A61K31/19 , A61K31/192 , A61K31/439 , A61K31/485 , A61K2300/00
摘要： The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an opioid (including salts thereof) and a salt of a non-steroidal anti-inflammatory drug (NSAID).
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公开(公告)号：US20110275658A1
公开(公告)日：2011-11-10
申请号：US13142784
申请日：2009-12-31
申请人： Kenneth L. Evenstad , Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Stephen M. Berge
发明人： Kenneth L. Evenstad , Christian F. Wertz , James S. Jensen , Victoria Ann O'Neill , Stephen M. Berge
IPC分类号： A61K31/485 , A61P25/04 , A61K31/192
CPC分类号： A61K9/2054 , A61K9/2013 , A61K31/10 , A61K31/135 , A61K31/19 , A61K31/192 , A61K31/439 , A61K31/485 , A61K2300/00
摘要： The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an opioid (including salts thereof) and a salt of a non-steroidal anti-inflammatory drug (NSAID).
摘要翻译： 本发明提供持续释放的口服药物组合物和使用方法。 缓释口服药物组合物包括阿片样物质（包括其盐）和非甾体抗炎药（NSAID）的盐。
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8.发明授权Lower fatty acid glyceride high-HLB lubricating suppository and method for making and using the same 失效低脂肪酸甘油酯高HLB润滑栓剂及其制备和使用方法
公开(公告)号：US4347237A
公开(公告)日：1982-08-31
申请号：US239882
申请日：1981-03-02
申请人： Kenneth L. Evenstad , Hiep Nguyen
发明人： Kenneth L. Evenstad , Hiep Nguyen
IPC分类号： A61K9/02
CPC分类号： A61K9/02 , Y10S424/14 , Y10S424/15
摘要： The disclosed lubricating suppository is formulated to have properties advantageous for coital use, including extraordinary water washability. The ingredients and phase relationships of the suppository composition provide a high degree of compatibility with water and with naturally-occurring vaginal moisture. The suppository composition contains a glyceride lubricant and can be lubricious with or without the presence of moisture. The suppository, which is solid at room temperature but melts in a short time at body temperature, is made by dissolving, for example, 10-30 parts by weight of high-HLB (e.g. >14) nonionic surfactant in 50-70 parts by weight of a molten, water-soluble polyoxyethylene glycol component and by dispersing or emulsifying 10-20 parts by weight of the glyceride (e.g. a triglyceride of C.sub.6 -C.sub.18 aliphatic carboxylic acids) included in the composition. In use, the suppository can be inserted prior to coitus and permitted to melt to a liquid, which is lubricious even in the absence of moisture, but still has the aforementioned extraordinary water washability.
摘要翻译： 公开的润滑栓剂被配制成具有有利于配偶使用的性质，包括非凡的水洗性。 栓剂组合物的成分和相位关系提供与水和天然存在的阴道水分的高度相容性。 栓剂组合物含有甘油酯润滑剂，并且可以在有或没有水分的情况下润滑。 在室温下固体但在体温短时间熔化的栓剂是通过将例如10-30重量份的高HLB（例如> 14）非离子表面活性剂溶解在50-70份中制成的栓剂 熔融的水溶性聚氧乙烯二醇组分的重量，并通过分散或乳化10-20重量份包含在组合物中的甘油酯（例如C 6 -C 18脂族羧酸的甘油三酯）。 在使用中，栓剂可以在交联之前插入并允许熔化成液体，即使在没有水分的情况下也是润滑的，但仍然具有上述非凡的水洗性。
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