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1.发明授权Systems and methods for performing correlation analysis on clinical outcome and characteristics of biological tissue 有权对生物组织的临床结局和特征进行相关分析的系统和方法公开(公告)号：US08737709B2
公开(公告)日：2014-05-27
申请号：US13459999
申请日：2012-04-30
申请人： Vidya Pundalik Kamath , Colin Craig Mcculloch , Megan Rothney , Alberto Santamaria-Pang , Brion Daryl Sarachan
发明人： Vidya Pundalik Kamath , Colin Craig Mcculloch , Megan Rothney , Alberto Santamaria-Pang , Brion Daryl Sarachan
CPC分类号： G06F19/345 , G06Q50/22 , G16H50/20
摘要： Embodiments disclosed herein include methods, systems, and devices for determining a positive or negative correlation between a clinical outcome and one or more features of biological tissue. An exemplary user interface enables a user to select a clinical outcome and one or more aspects of a displayed field-of-view of biological tissue. Exemplary embodiments may automatically perform correlation analysis between the selected clinical outcome and one or more features characteristic of the user-selected aspects of the field-of-view of biological tissue. For example, exemplary embodiments may automatically perform correlation analysis between the selected clinical outcome and one or more features characteristic of one or more biological units in the biological tissue.
摘要翻译： 本文公开的实施方案包括用于确定临床结果与生物组织的一个或多个特征之间的正相关或负相关的方法，系统和装置。 示例性用户界面使得用户能够选择生物组织的显示视野的临床结果和一个或多个方面。 示例性实施例可以自动执行所选择的临床结果与生物组织的视野的用户选定方面特征的一个或多个特征之间的相关性分析。 例如，示例性实施例可以自动执行所选临床结果与生物组织中一个或多个生物单元特征的一个或多个特征之间的相关性分析。
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2.发明申请公开(公告)号：US20130290006A1
公开(公告)日：2013-10-31
申请号：US13459999
申请日：2012-04-30
申请人： Vidya Pundalik Kamath , Colin Craig McCulloch , Megan Rothney , Alberto Santamaria-Pang , Brion Daryl Sarachan
发明人： Vidya Pundalik Kamath , Colin Craig McCulloch , Megan Rothney , Alberto Santamaria-Pang , Brion Daryl Sarachan
IPC分类号： G06Q50/22
CPC分类号： G06F19/345 , G06Q50/22 , G16H50/20
摘要： Embodiments disclosed herein include methods, systems, and devices for determining a positive or negative correlation between a clinical outcome and one or more features of biological tissue. An exemplary user interface enables a user to select a clinical outcome and one or more aspects of a displayed field-of-view of biological tissue. Exemplary embodiments may automatically perform correlation analysis between the selected clinical outcome and one or more features characteristic of the user-selected aspects of the field-of-view of biological tissue. For example, exemplary embodiments may automatically perform correlation analysis between the selected clinical outcome and one or more features characteristic of one or more biological units in the biological tissue.
摘要翻译： 本文公开的实施方案包括用于确定临床结果与生物组织的一个或多个特征之间的正相关或负相关的方法，系统和装置。 示例性用户界面使得用户能够选择生物组织的显示视野的临床结果和一个或多个方面。 示例性实施例可以自动执行所选择的临床结果与生物组织的视野的用户选定方面特征的一个或多个特征之间的相关性分析。 例如，示例性实施例可以自动执行所选临床结果与生物组织中一个或多个生物单元特征的一个或多个特征之间的相关性分析。
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3.发明申请SYSTEMS AND METHODS FOR SELECTING AND ANALYZING PARTICLES IN A BIOLOGICAL TISSUE 审中-公开在生物组织中选择和分析颗粒的系统和方法公开(公告)号：US20150032671A9
公开(公告)日：2015-01-29
申请号：US13460100
申请日：2012-04-30
CPC分类号： G06K9/00127 , G06F19/26
摘要： Systems and methods are disclosed for jointly presenting and analyzing morphological characteristics and biomarker expression levels of a biological sample. The systems and methods may utilize a morphological selection component to isolate a population of biological particles in a biological sample for exclusion from further processing. In addition, the systems and methods may simultaneously render morphological and statistical representations of the biological sample on a user interface.
摘要翻译： 公开了用于共同呈现和分析生物样品的形态特征和生物标志物表达水平的系统和方法。 系统和方法可以利用形态学选择组分来分离生物样品中的生物颗粒群，以免进一步处理。 此外，系统和方法可以同时在用户界面上呈现生物样品的形态和统计学表示。
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公开(公告)号：US20130290225A1
公开(公告)日：2013-10-31
申请号：US13460100
申请日：2012-04-30
CPC分类号： G06K9/00127 , G16B45/00
摘要： Systems and methods are disclosed for jointly presenting and analyzing morphological characteristics and biomarker expression levels of a biological sample. The systems and methods may utilize a morphological selection component to isolate a population of biological particles in a biological sample for exclusion from further processing. In addition, the systems and methods may simultaneously render morphological and statistical representations of the biological sample on a user interface.
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5.发明授权Systems and methods for performing quality review scoring of biomarkers and image analysis methods for biological tissue 有权用于生物标志物质量评估评分和生物组织图像分析方法的系统和方法公开(公告)号：US09036888B2
公开(公告)日：2015-05-19
申请号：US13460081
申请日：2012-04-30
CPC分类号： G09G5/026 , G01N15/1475 , G06K9/0014 , G06K9/6253 , G06K9/6263 , G09G2340/12 , G09G2370/022 , G09G2380/08
摘要： Exemplary embodiments include methods, systems, and devices for enabling users to provide quality scores for indicating the quality of image analysis methods performed on images of biological tissue. An exemplary user interface displays results of an image analysis method performed on an image of biological tissue in an overlaid manner on an image of biological tissue. The exemplary user interface enable a user to provide, directly on the user interface, one or more quality scores to indicate the user's assessment of the quality of the image analysis performed on the image. Exemplary embodiments store the quality scores provided by the user in association with the image analysis method and the image of biological tissue.
摘要翻译： 示例性实施例包括用于使用户能够提供用于指示对生物组织的图像执行的图像分析方法的质量的质量分数的方法，系统和装置。 示例性用户界面以生物组织的图像的重叠方式显示对生物组织的图像执行的图像分析方法的结果。 示例性用户界面使得用户能够直接在用户界面上提供一个或多个质量得分以指示用户对图像上执行的图像分析的质量的评估。 示例性实施例与图像分析方法和生物组织的图像相关联地存储由用户提供的质量得分。
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6.发明申请SYSTEMS AND METHODS FOR PERFORMING QUALITY REVIEW SCORING OF BIOMARKERS AND IMAGE ANALYSIS METHODS FOR BIOLOGICAL TISSUE 有权生物标志质量评估评估系统与方法及生物组织图像分析方法公开(公告)号：US20130287283A1
公开(公告)日：2013-10-31
申请号：US13460081
申请日：2012-04-30
CPC分类号： G09G5/026 , G01N15/1475 , G06K9/0014 , G06K9/6253 , G06K9/6263 , G09G2340/12 , G09G2370/022 , G09G2380/08
摘要： Exemplary embodiments include methods, systems, and devices for enabling users to provide quality scores for indicating the quality of image analysis methods performed on images of biological tissue. An exemplary user interface displays results of an image analysis method performed on an image of biological tissue in an overlaid manner on an image of biological tissue. The exemplary user interface enable a user to provide, directly on the user interface, one or more quality scores to indicate the user's assessment of the quality of the image analysis performed on the image. Exemplary embodiments store the quality scores provided by the user in association with the image analysis method and the image of biological tissue.
摘要翻译： 示例性实施例包括用于使用户能够提供用于指示对生物组织的图像执行的图像分析方法的质量的质量分数的方法，系统和装置。 示例性用户界面以生物组织的图像的重叠方式显示对生物组织的图像执行的图像分析方法的结果。 示例性用户界面使得用户能够直接在用户界面上提供一个或多个质量得分以指示用户对图像上执行的图像分析的质量的评估。 示例性实施例与图像分析方法和生物组织的图像相关联地存储由用户提供的质量得分。
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7.发明申请SYSTEMS AND METHODS FOR ANALYZING BIOMARKER CO-LOCALIZATION IN A BIOLOGICAL TISSUE 审中-公开用于分析生物组织中的生物标记物定位的系统和方法公开(公告)号：US20130286043A1
公开(公告)日：2013-10-31
申请号：US13460018
申请日：2012-04-30
CPC分类号： G09G5/026 , G06F3/1423 , G09G2340/12 , G09G2370/022 , G09G2380/08 , G16B20/00 , G16B45/00
摘要： Systems and methods are disclosed for selecting a field of view for a biological sample, selecting first and second biomarkers, each having a corresponding image in a multiplexed biomarker image of the selected field of view, automatically analyzing expression level criterion for each of the first and second biomarkers, rendering the corresponding images of the selected field-of-view in an overlaid manner on the graphical user interface and highlighting a first set of biological units in the biological tissue that meets both the biomarker expression level criterion for both the first and second biomarkers.
摘要翻译： 公开了用于选择生物样品的视野的系统和方法，选择第一和第二生物标志物，每个生物标志物在所选视场的复用生物标志物图像中具有相应的图像，自动分析第一和第 第二生物标志物，以覆盖的方式将所选择的视野的相应图像呈现在图形用户界面上，并突出显示生物组织中的第一组生物标志物表达水平标准，用于第一和第二 生物标志物。
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8.发明申请SYSTEMS AND METHODS FOR SELECTION AND DISPLAY OF MULTIPLEXED IMAGES OF BIOLOGICAL TISSUE 审中-公开用于选择和显示生物组织的多重图像的系统和方法公开(公告)号：US20130286038A1
公开(公告)日：2013-10-31
申请号：US13459958
申请日：2012-04-30
IPC分类号： G09G5/02
CPC分类号： G06T7/0012 , G06K9/00134 , G06T2207/30024
摘要： Exemplary embodiments enable selection and overlaid display of the expression of one or more biomarkers and/or one or more DNA sequences in a field-of-view of a biological tissue. The expressions of the biomarkers and/or DNA sequences are represented in one or more user-selected colors. The color settings are stored in associated with the biomarkers and/or DNA sequences such that a first user-selected color associated with a first biomarker in the saved color settings is automatically selected in response to receiving user input selecting the first biomarker. Similarly, a second user-selected color associated with a first DNA sequence in the saved color settings is automatically selected in response to receiving user input selecting the first DNA sequence.
摘要翻译： 示例性实施方案使得能够在生物组织的视场中选择和重叠显示一种或多种生物标志物和/或一种或多种DNA序列的表达。 生物标志物和/或DNA序列的表达以一种或多种用户选择的颜色表示。 颜色设置被存储在生物标志物和/或DNA序列相关联中，使得响应于接收到选择第一生物标志物的用户输入，自动选择与所保存的颜色设置中的第一生物标志物相关联的第一用户选择的颜色。 类似地，响应于接收到选择第一DNA序列的用户输入，自动选择与保存的颜色设置中的第一DNA序列相关联的第二用户选择的颜色。
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9.发明授权公开(公告)号：US07123760B2
公开(公告)日：2006-10-17
申请号：US10301018
申请日：2002-11-21
IPC分类号： G06K9/00
CPC分类号： G06T5/50 , G06T7/0012 , G06T7/11 , G06T7/174 , G06T7/187 , G06T7/49 , G06T2200/04 , G06T2207/10081 , G06T2207/30008 , G06T2207/30101
摘要： A technique is provided for automatically identifying regions of bone or other structural regions within a reconstructed CT volume data set. The technique identifies and labels regions within the data set and computes various statistics for the regions. A rule-based classifier processes the statistics to classify each region. Incidental connections between disparate regions are eliminated. A structure mask, such as a bone mask, is then constructed after exclusion of regions of interest, such as a vascular map. The structure mask may then be used to construct a volume rendering free of the structure, such as bone-free.
摘要翻译： 提供了一种用于自动识别重建CT体积数据集内的骨骼或其他结构区域的技术。 该技术识别和标记数据集内的区域，并计算各区域的各种统计信息。 基于规则的分类器处理统计信息以对每个区域进行分类。 消除了不同区域之间的偶然连接。 然后在排除感兴趣区域（例如血管图）之后构建结构掩模，例如骨掩模。 然后可以使用结构掩模来构造没有结构的体绘制，例如无骨。
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公开(公告)号：US07177453B2
公开(公告)日：2007-02-13
申请号：US10304581
申请日：2002-11-26
申请人： Srikanth Suryanarayanan , Rakesh Mullick , Vidya Pundalik Kamath , Yogisha Mallya , Robert F. Senzig
发明人： Srikanth Suryanarayanan , Rakesh Mullick , Vidya Pundalik Kamath , Yogisha Mallya , Robert F. Senzig
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06T7/11 , G06T2207/10116 , G06T2207/30008 , G06T2207/30101
摘要： A technique is provided for partitioning an imaged volume into two or more sub-volumes. The technique identifies partition lines which separate the sub-volumes by generating a profile, such as a bone profile, which is then analyzed to determine the placement of the partition lines. In one embodiment, placement of the partition lines is determined automatically by applying one or more sets of hierarchical rules to the profile. After separation of the imaged volume into sub-volumes, each sub-volume may be differentially segmented such that segmentation is customized for the sub-volume. Likewise, after separation of the imaged volume into sub-volumes, the acquisition parameters for each sub-volume may be customized for subsequent acquisitions.
摘要翻译： 提供了一种用于将成像的体积分成两个或更多个子体积的技术。 该技术通过生成轮廓（例如骨骼轮廓）来分离子体积的分割线，然后分析轮廓以确定分割线的位置。 在一个实施例中，通过将一个或多个分层规则集合应用于简档来自动确定分割线的放置。 在将成像的体积分离成子体积之后，每个子体积可以被差异地分段，使得针对子体积定制分割。 同样，在将成像的体积分成子体积之后，可以为每个子体积的采集参数定制以用于随后的采集。
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